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gastroenterology

Practice targeted AMC-style multiple-choice questions on gastroenterology.

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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 45-year-old male presents with intermittent abdominal pain and melena. The provided image was obtained. What is the most likely underlying cause?

A. Henoch-Schönlein purpura
B. Cystic fibrosis
C. Meckel's diverticulum
D. Peutz-Jeghers syndrome
E. Blue rubber bleb nevus syndrome
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 62-year-old male with a history of hepatitis C presents with new onset jaundice and ascites. His AFP is markedly elevated. A contrast-enhanced ultrasound is performed, as shown. What is the MOST appropriate next step in management?

A. Initiate systemic chemotherapy
B. Referral for liver transplant evaluation
C. Order a triple-phase CT scan of the abdomen
D. Perform a percutaneous liver biopsy
E. Start sorafenib therapy
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 45-year-old male with a known history of Blue Rubber Bleb Naevus Syndrome, characterised by recurrent gastrointestinal bleeding and multiple cutaneous vascular lesions, presents to the emergency department with acute onset severe, colicky abdominal pain, nausea, and vomiting. On examination, his abdomen is distended and diffusely tender with reduced bowel sounds. Vital signs are within normal limits. An urgent abdominal CT scan is performed. Based on the clinical presentation and the findings demonstrated in the image, what is the most appropriate immediate next step in management?

A. Urgent surgical exploration and reduction/resection
B. Attempt air enema reduction under fluoroscopy
C. Urgent upper gastrointestinal endoscopy for reduction
D. Nasogastric tube insertion, intravenous fluids, and observation
E. Obtain an urgent abdominal MRI for further characterisation
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 55-year-old patient with a history of solid organ transplant on immunosuppressive therapy presents with a two-week history of intermittent fever, chills, and dull right upper quadrant pain. On examination, there is mild tenderness in the right upper quadrant. Blood tests reveal a white cell count of 14 x 10^9/L and CRP of 120 mg/L. Imaging is performed. Considering the clinical context and the provided images, what is the most appropriate immediate next step in the management of this patient?

A. Arrange for repeat cross-sectional imaging in 4-6 weeks to assess for interval change
B. Schedule surgical exploration and debridement of the lesion
C. Order serological tests for common parasitic infections, including Echinococcus species
D. Percutaneous aspiration and drainage of the lesion for microbiological and pathological analysis
E. Initiate empirical broad-spectrum intravenous antibiotics covering typical bacterial pathogens
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Ileitis terminalis bei langjaehrigem Morbus Crohn 63W - CT und MRT - 001
Image by Hellerhoff CC BY-SA 4.0 · Source

A 32-year-old male with a history of Crohn's disease presents with worsening abdominal pain, diarrhea, and a low-grade fever. He reports that his symptoms have been progressively worsening over the past few months despite being on maintenance therapy with azathioprine. A CT scan of the abdomen and pelvis is performed, as shown. Based on the imaging findings, which of the following is the MOST appropriate next step in management?

A. Increase the dose of azathioprine
B. Perform a colonoscopy with biopsy
C. Initiate anti-TNF therapy
D. Prescribe a course of oral corticosteroids
E. Start a trial of antibiotics for possible infectious colitis
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Ileitis terminalis bei langjaehrigem Morbus Crohn 63W - CT und MRT - 001
Image by Hellerhoff CC BY-SA 4.0 · Source

A 28-year-old male with Crohn's presents with increased abdominal pain, non-bloody diarrhea, and fatigue for 3 weeks. He denies fever. Exam shows mild RLQ tenderness. Labs show elevated CRP. Imaging is shown. What is the MOST appropriate next step?

A. Prescribe antibiotics for possible infectious colitis
B. Schedule a colonoscopy with biopsy
C. Start a course of oral corticosteroids
D. Initiate anti-TNF therapy
E. Increase mesalamine dose
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 65-year-old male with new onset ascites and elevated ALP has the imaging shown. What is the MOST likely primary malignancy?

A. Colorectal
B. Cholangiocarcinoma
C. Gastric
D. Hepatocellular
E. Pancreatic
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 65-year-old male presents with a 3-month history of unintentional weight loss and early satiety. Gastroscopy and biopsy confirmed a gastric mixed adenoneuroendocrine carcinoma. Staging CT imaging is shown. Considering the clinical presentation and the findings on the provided imaging, what is the most appropriate initial management strategy?

A. Commence somatostatin analogue therapy.
B. Proceed with surgical resection of hepatic lesions.
C. Monitor with serial CT scans and symptomatic management.
D. Initiate systemic chemotherapy.
E. Plan for palliative external beam radiotherapy to the liver.
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Elective abdominal ultrasonography of a 64 year old woman with past colicky pain but no current pain. It shows a mildly dilated common bile duct with what appears to be a gallstone (black arrow). The green and blue dots are blood flow, since the exam is done as a Doppler ultrasound to distinguish the bile duct from blood vessels.
Image by Mikael Häggström CC0 1.0 · Source

A 64-year-old woman presents for a routine health check. She reports intermittent episodes of colicky abdominal pain over the past year, which have since resolved. An abdominal ultrasound, as shown, was performed. Liver function tests are normal. Which of the following is the MOST appropriate next step in management?

A. HIDA scan to assess gallbladder function
B. Ursodeoxycholic acid therapy
C. ERCP with sphincterotomy
D. Referral for elective cholecystectomy
E. Observation with repeat ultrasound in 6 months
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 70-year-old man presents with a 3-month history of worsening constipation, occasional bright red rectal bleeding, and unexplained fatigue. His GP notes mild pallor. Full blood count reveals a haemoglobin of 105 g/L and low ferritin. A colonoscopy is performed, and the image provided is a representative view of a finding in the sigmoid colon. Biopsies were taken. Considering the clinical context and the endoscopic appearance, which of the following is the most appropriate next step in the management pathway to determine the extent of disease?

A. Referral for immediate surgical resection
B. Repeat colonoscopy in 6 months to assess response to medical therapy
C. CT scan of chest, abdomen, and pelvis for staging
D. PET scan for metabolic activity assessment
E. Commencement of iron supplementation and review in 4 weeks
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 58-year-old male presents with fatigue and microcytic anemia. He denies overt bleeding but reports occasional dark stools. Colonoscopy reveals the image shown. Biopsies confirm adenocarcinoma. What is the MOST appropriate next investigation to stage the cancer?

A. Carcinoembryonic antigen (CEA) level
B. Endoscopic ultrasound
C. MRI of the abdomen and pelvis
D. CT scan of the chest, abdomen, and pelvis
E. PET-CT scan
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A 32-year-old man presents to the emergency department with severe abdominal pain that started suddenly 6 hours ago. The pain is located in the right lower quadrant and is associated with nausea and vomiting. On examination, he has rebound tenderness and guarding in the right lower quadrant. His temperature is 37.8°C, heart rate is 110 beats per minute, and blood pressure is 120/80 mmHg. A CT scan of the abdomen shows an inflamed appendix with surrounding fat stranding. What is the most appropriate next step in management?

A. Percutaneous drainage
B. Laparoscopic cholecystectomy
C. Appendectomy
D. Observation and repeat imaging
E. Intravenous antibiotics only
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Ileitis terminalis bei langjaehrigem Morbus Crohn 63W - CT und MRT - 001
Image by Hellerhoff CC BY-SA 4.0 · Source

A 63-year-old woman with a 20-year history of Crohn's disease presents with a one-month history of worsening colicky abdominal pain, bloating, and occasional non-bilious vomiting, associated with a 3kg weight loss. She reports reduced stool frequency. She is currently managed with mesalazine and azathioprine. Her vital signs are stable (BP 120/75, HR 82, Temp 36.8), and physical examination reveals mild right lower quadrant tenderness without guarding or rebound. Bowel sounds are hyperactive. Imaging is performed. Considering the clinical presentation, her current therapy, and the findings suggested by the provided images, which of the following represents the most appropriate next step in this patient's management?

A. Performing a colonoscopy with attempted balloon dilation
B. Recommending a high-fibre diet and increased fluid intake
C. Initiating therapy with an anti-TNF agent such as infliximab
D. Increasing the dose of azathioprine and adding oral corticosteroids
E. Referral for surgical consultation regarding potential resection
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 72-year-old woman presents with a 3-month history of worsening constipation, occasional bright red rectal bleeding, and unintentional weight loss of 4 kg. She reports feeling increasingly tired. Her past medical history includes hypertension and osteoarthritis. On examination, her vital signs are stable. Abdominal examination is soft, non-tender, with no palpable masses. Digital rectal examination reveals no palpable lesion. Blood tests show a haemoglobin of 108 g/L, MCV 78 fL, and ferritin 12 µg/L. A colonoscopy was performed, and the image provided was captured during the procedure. Considering the clinical presentation and the finding observed during the colonoscopy, which of the following investigations is most crucial for determining the extent of disease and guiding definitive treatment planning within the multidisciplinary team framework?

A. Repeat colonoscopy in 3 months
B. Commencement of iron supplementation and review in 4 weeks
C. Urgent surgical consultation for immediate resection
D. CT scan of chest, abdomen, and pelvis
E. Referral for palliative care assessment
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 70-year-old male presents with jaundice and abdominal distension. The provided image was obtained. What is the MOST likely underlying cause of the jaundice?

A. Choledocholithiasis
B. Intrahepatic cholestasis
C. Primary sclerosing cholangitis
D. Gilbert's syndrome
E. Pancreatic head mass
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 58-year-old male presents with iron deficiency anemia and a change in bowel habits. A colonoscopy was performed, and the image is shown. Biopsies were taken. Assuming the biopsies confirm malignancy, what is the next step?

A. Repeat colonoscopy in 6 months
B. Referral to a gastroenterologist for endoscopic mucosal resection
C. Fecal immunochemical test (FIT)
D. Initiate chemotherapy
E. CT scan of the abdomen and pelvis
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 72-year-old male with acute cholangitis is undergoing ERCP for stone extraction. The image is obtained after cannulation. Based on the findings, what is the most appropriate immediate next step in the procedure?

A. Insert nasobiliary drain
B. Terminate procedure and give antibiotics
C. Attempt basket extraction
D. Endoscopic sphincterotomy
E. Perform mechanical lithotripsy
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 70-year-old male with known gastric MANEC presents with worsening jaundice and ascites. The provided CT scan was performed. Which of the following serum markers would be MOST useful in monitoring disease progression in this patient?

A. Amylase
B. Chromogranin A
C. CEA
D. Alpha-fetoprotein
E. CA 19-9
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 62-year-old male presents with jaundice and right upper quadrant pain. Initial labs show elevated bilirubin and alkaline phosphatase. An ERCP is performed, and the image is obtained. What is the MOST appropriate next step in management?

A. Percutaneous transhepatic biliary drainage
B. Cholecystectomy
C. Sphincterotomy and stone extraction
D. Observation with serial liver function tests
E. Ursodeoxycholic acid administration
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 65-year-old man presents with 2 days of left lower quadrant abdominal pain, fever, and nausea. On examination, he is afebrile, haemodynamically stable, with localised tenderness in the LLQ. Blood tests show a WCC of 14.5. A CT scan of the abdomen and pelvis is performed. Considering the clinical presentation and the findings demonstrated in the image, what is the most appropriate initial management plan?

A. Admission for IV antibiotics and observation
B. Colonoscopy within 24 hours
C. Urgent surgical consultation for laparotomy
D. Outpatient oral antibiotics and analgesia
E. Discharge with advice to return if symptoms worsen
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 62-year-old male with cirrhosis secondary to alcohol abuse presents with new-onset ascites and a palpable liver mass. His AFP is 600 ng/mL. A contrast-enhanced ultrasound is performed. What is the MOST appropriate next step in confirming the diagnosis and guiding management?

A. Repeat AFP in 3 months
B. Initiate sorafenib therapy
C. Liver biopsy
D. Administer systemic chemotherapy
E. Perform a diagnostic paracentesis
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male presents to the emergency department with right upper quadrant abdominal pain, weight loss, and jaundice. He has a known history of chronic hepatitis C infection. His vital signs are stable. Physical examination reveals hepatomegaly and mild ascites. The patient denies any alcohol consumption. Laboratory investigations reveal elevated alpha-fetoprotein (AFP) levels. A CT scan of the abdomen with and without contrast is performed, as shown. Based on the imaging and clinical findings, what is the MOST appropriate next step in management?

A. Referral to a hepatologist for consideration of liver transplantation
B. Percutaneous liver biopsy for histological confirmation
C. Observation with serial AFP measurements every 3 months
D. Administration of intravenous antibiotics for suspected cholangitis
E. Initiation of antiviral therapy for hepatitis C
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 70-year-old male with known cirrhosis secondary to non-alcoholic fatty liver disease presents for routine surveillance. He has Child-Pugh class A cirrhosis and ECOG performance status 0. His recent surveillance ultrasound showed a new 3 cm lesion in segment VIII. Serum alpha-fetoprotein is elevated at 450 ng/mL. A contrast-enhanced ultrasound was performed, and representative images are shown. Considering the patient's history, clinical status, laboratory results, and the findings demonstrated in the contrast-enhanced ultrasound images, what is the MOST appropriate immediate next step in the management of this patient?

A. Referral to a multidisciplinary liver tumour board for treatment planning
B. Start systemic chemotherapy with Sorafenib
C. Repeat the contrast-enhanced ultrasound in 3 months
D. Initiate palliative care referral
E. Perform an urgent liver biopsy of the lesion
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Acute cholecystitis with gallbladder wall thickening, a large gallstone, and a large gallbladder
Image by James Heilman, MD CC BY-SA 4.0 · Source

A 52-year-old female presents with right upper quadrant pain, fever, and leukocytosis. The image shows the likely cause. What is the MOST appropriate initial management?

A. Ursodeoxycholic acid
B. Oral antibiotics and outpatient follow-up
C. IV fluids, analgesia, and surgical consultation
D. Hepatobiliary iminodiacetic acid (HIDA) scan
E. Endoscopic retrograde cholangiopancreatography (ERCP)
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A 25-year-old man presents to the emergency department with severe abdominal pain that started around his umbilicus and has now localized to the right lower quadrant. He has nausea and has vomited twice. On examination, he has tenderness and guarding in the right lower quadrant. His temperature is 37.8°C, and his white blood cell count is elevated. What is the most likely diagnosis?

A. Diverticulitis
B. Renal colic
C. Cholecystitis
D. Gastroenteritis
E. Acute appendicitis
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Acute cholecystitis with gallbladder wall thickening, a large gallstone, and a large gallbladder
Image by James Heilman, MD CC BY-SA 4.0 · Source

A 62-year-old woman presents with right upper quadrant pain, fever, and leukocytosis. An abdominal CT scan is performed, as shown. She has a history of similar episodes that resolved spontaneously. What is the MOST appropriate next step in management?

A. IV antibiotics and analgesia
B. Laparoscopic cholecystectomy
C. Oral ursodeoxycholic acid
D. ERCP with sphincterotomy
E. Percutaneous cholecystostomy tube placement
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male with a history of hepatitis C presents with new onset ascites and right upper quadrant pain. His AFP is elevated. A CT scan of the abdomen with and without contrast is performed, as shown. What is the MOST appropriate next step in management?

A. Start sorafenib therapy
B. Referral for liver transplant evaluation
C. Initiate systemic chemotherapy
D. Perform a percutaneous liver biopsy
E. Order a triple phase MRI of the liver
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A 25-year-old woman presents to the clinic with a 2-week history of abdominal pain and diarrhea. She reports that the pain is crampy and occurs mostly in the lower abdomen. She has also noticed some blood in her stool. She has no significant past medical history and is not on any medications. On examination, she has mild tenderness in the lower abdomen but no rebound tenderness or guarding. What is the most likely diagnosis?

A. Diverticulitis
B. Ulcerative colitis
C. Irritable bowel syndrome
D. Celiac disease
E. Gastroenteritis
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 48-year-old man with multiple cutaneous hemangiomas presents with crampy abdominal pain and guaiac-positive stools. The provided image was obtained. What is the MOST appropriate initial diagnostic test to identify the source of bleeding?

A. Tagged red blood cell scan
B. Upper endoscopy
C. Barium swallow
D. Colonoscopy
E. Capsule endoscopy
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A 32-year-old male presents to his general practitioner complaining of severe anal pain, especially during and after bowel movements. He also reports seeing bright red blood on the toilet paper. On examination, there is a visible tear in the anal mucosa at the 6 o'clock position. Which of the following is the MOST appropriate initial management strategy?

A. Stool softeners, topical analgesics, and sitz baths
B. Incision and drainage
C. High-fibre diet alone
D. Lateral internal sphincterotomy
E. Rubber band ligation
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 62-year-old male presents with jaundice and RUQ pain. An ERCP is performed, and the image is obtained. Following successful stone extraction, what is the MOST appropriate next step in managing this patient?

A. Sphincteroplasty
B. Ursodeoxycholic acid
C. Observation with serial LFTs
D. Percutaneous cholecystostomy
E. Cholecystectomy
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A 32-year-old woman presents to her general practitioner complaining of severe anal pain during and after bowel movements, along with bright red blood on the toilet paper. She reports constipation and straining during defecation. Examination reveals a visible longitudinal tear in the anal mucosa at the 6 o'clock position. Which of the following is the MOST appropriate initial management strategy, according to Australian guidelines?

A. Recommend regular sitz baths with antiseptic solution.
B. Prescribe oral antibiotics to treat potential infection.
C. Advise increased fluid and fibre intake, stool softeners, and topical application of a local anaesthetic and a topical nitrate ointment.
D. Refer for surgical lateral internal sphincterotomy.
E. Order a colonoscopy to rule out inflammatory bowel disease.
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A 50-year-old woman presents with increasing abdominal swelling and early satiety. Examination reveals ascites. Which investigation is most crucial to guide initial management?

A. Diagnostic paracentesis
B. Complete blood count
C. Abdominal ultrasound
D. Liver function tests
E. Serum albumin and ascitic fluid protein
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 68-year-old presents with a 3-day history of fever, jaundice, and severe RUQ pain radiating to the back. Vitals: T 38.5°C, BP 110/70, HR 95. LFTs show bilirubin 150, ALP 450, ALT 120. An ERCP is performed for stone extraction. The image is captured during the procedure after cannulation. Considering the findings demonstrated in the image, what is the most appropriate immediate next step in management during the current procedure?

A. Proceed with mechanical lithotripsy after sphincterotomy.
B. Place a biliary stent for decompression.
C. Attempt extraction with a balloon catheter after sphincterotomy.
D. Refer for urgent laparoscopic common bile duct exploration.
E. Terminate the procedure and manage medically.
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Upright X-ray demonstrating small bowel obstruction
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 72-year-old male presents with abdominal distension, vomiting, and inability to pass flatus for 48 hours. He has a history of prior bowel resection. Examination reveals a tympanitic abdomen and tenderness to palpation. His vitals are stable. An abdominal X-ray is performed, as shown. Considering the clinical context and the radiographic findings, what is the MOST likely underlying cause of this presentation?

A. Post-surgical adhesions
B. Inflammatory bowel disease stricture
C. Volvulus
D. Hernia
E. Malignancy
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 62-year-old male with a history of hepatitis C presents with new onset ascites and right upper quadrant pain. His AFP is markedly elevated. A contrast-enhanced ultrasound is performed, as shown. What is the MOST appropriate next step in management?

A. Referral for liver transplant evaluation
B. Initiate sorafenib therapy
C. Perform a percutaneous liver biopsy
D. Schedule a follow-up ultrasound in 3 months
E. Order a CT scan of the abdomen with IV contrast
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Elective abdominal ultrasonography of a 64 year old woman with past colicky pain but no current pain. It shows a mildly dilated common bile duct with what appears to be a gallstone (black arrow). The green and blue dots are blood flow, since the exam is done as a Doppler ultrasound to distinguish the bile duct from blood vessels.
Image by Mikael Häggström CC0 1.0 · Source

A 64-year-old woman reports intermittent RUQ pain. She denies jaundice or fever. An abdominal ultrasound was performed, image shown. Besides referral for surgery, what is the MOST appropriate next step in management?

A. Start prophylactic antibiotics
B. Repeat ultrasound in 6 months
C. Administer ursodeoxycholic acid
D. Prescribe a low-fat diet
E. Arrange an MRCP
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 68-year-old male presents to his GP complaining of a change in bowel habit over the past 6 months. He reports increasing constipation alternating with episodes of diarrhea. He also mentions unintentional weight loss of approximately 5 kg during this period. He denies any family history of bowel cancer. A colonoscopy was performed, and a representative image is shown. Assuming the lesion is confirmed as malignant, what is the MOST appropriate next step in the management of this patient?

A. Referral for palliative care
B. Repeat colonoscopy in 3 years
C. CT scan of the chest, abdomen, and pelvis
D. Initiate adjuvant chemotherapy with FOLFOX
E. Administer a course of broad-spectrum antibiotics
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 68-year-old male with known Hepatitis B related cirrhosis and a history of alcohol excess presents for routine surveillance. His alpha-fetoprotein (AFP) level, which has been stable at 15 ng/mL for the past two years, is now noted to be 185 ng/mL. A screening ultrasound performed three months prior was reported as showing diffuse parenchymal changes consistent with cirrhosis but no focal lesions. Due to the elevated AFP, a repeat ultrasound was performed, which identified a 2.5 cm nodule in segment VIII. To further characterise this lesion, a contrast-enhanced ultrasound (CEUS) was performed, and the images provided are representative findings from this study. The patient has well-compensated cirrhosis (Child-Pugh A) and no significant comorbidities. His liver function tests are within normal limits except for a slightly elevated GGT. Given the clinical context and the findings demonstrated in the provided images, what is the most appropriate next step in the management of this patient?

A. Referral for urgent liver transplant assessment
B. Repeat the contrast-enhanced ultrasound in 3 months to assess for interval change
C. Perform a percutaneous biopsy of the lesion for histological confirmation
D. Referral for discussion regarding locoregional therapy (e.g., ablation) or surgical resection
E. Initiate systemic therapy with sorafenib
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Upright X-ray demonstrating small bowel obstruction
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 72-year-old male presents with abdominal distension, vomiting, and inability to pass flatus for 48 hours. He has a history of prior bowel resection. Examination reveals a tympanitic abdomen and tenderness to palpation. His vitals are stable. An abdominal X-ray is performed, as shown. Considering the clinical context and the radiographic findings, what is the primary purpose of inserting a nasogastric tube in this patient?

A. Obtaining a sample of gastric contents for analysis.
B. Administering oral contrast for further imaging.
C. Decompressing the dilated bowel loops and reducing vomiting.
D. Providing nutritional support to the patient.
E. Facilitating the passage of flatus.
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 35-year-old male presents to the ED with intermittent abdominal pain, nausea, and melena. He has multiple cutaneous hemangiomas. A CT scan is performed, as shown. What is the MOST appropriate next step in management?

A. Initiation of high-dose corticosteroids
B. Surgical resection
C. Observation with serial abdominal exams
D. Empiric antibiotic therapy
E. Colonoscopy with polypectomy
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A 58-year-old man presents to the emergency department with severe epigastric pain radiating to the back, which started suddenly 6 hours ago. He has a history of alcohol use disorder and has been consuming large amounts of alcohol daily for the past 10 years. On examination, he is diaphoretic and in distress, with a blood pressure of 100/60 mmHg, heart rate of 120 bpm, and respiratory rate of 22 breaths per minute. Abdominal examination reveals tenderness in the epigastric region with guarding. Laboratory tests show elevated serum amylase and lipase levels. Which of the following is the most appropriate initial management step?

A. Intravenous fluid resuscitation
B. Immediate surgical consultation
C. Administration of proton pump inhibitors
D. Initiation of broad-spectrum antibiotics
E. Nasogastric tube insertion
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 62-year-old male presents with rectal bleeding and altered bowel habits. Colonoscopy findings are shown. What is the MOST appropriate next step?

A. Repeat colonoscopy in 1 year
B. Prescribe high-fiber diet
C. Surgical resection
D. Initiate chemotherapy
E. Administer antibiotics
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Ileitis terminalis bei langjaehrigem Morbus Crohn 63W - CT und MRT - 001
Image by Hellerhoff CC BY-SA 4.0 · Source

A 63-year-old woman with a 20-year history of Crohn's disease presents with a one-month history of worsening abdominal pain, bloating, and occasional vomiting, associated with a 3kg weight loss. She is currently managed with mesalazine and azathioprine. Her vital signs are stable, and physical examination reveals mild right lower quadrant tenderness. Imaging is performed. Considering the clinical presentation and the findings demonstrated in the provided images, which of the following management approaches is most likely indicated?

A. Addition of an anti-TNF alpha agent
B. Initiation of a systemic corticosteroid course
C. Switching azathioprine to methotrexate
D. Increasing the dose of mesalazine
E. Surgical consultation for potential intervention
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Diverticular disease
Image by James Heilman, MD CC BY-SA 4.0 · Source

A 65-year-old man presents to the emergency department with a 2-day history of worsening left lower quadrant abdominal pain, associated with fever and chills. He reports a change in bowel habit with increased constipation. On examination, he is febrile at 38.6°C and has significant tenderness and guarding in the left iliac fossa. His white cell count is 18 x 10^9/L. A CT scan of the abdomen and pelvis is performed (image provided). Considering the patient's presentation and the findings on the provided image, which of the following represents the most appropriate initial management strategy?

A. Prescribe oral antibiotics and advise outpatient follow-up with his general practitioner.
B. Schedule an urgent colonoscopy to assess the extent of the disease process.
C. Initiate intravenous broad-spectrum antibiotics and arrange hospital admission for monitoring.
D. Provide analgesia and antiemetics, and discharge home with instructions to return if symptoms worsen.
E. Arrange urgent surgical review for consideration of immediate operative intervention.
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A 3-month-old baby presents with abdominal swelling and constipation. A rectal biopsy shows the absence of ganglion cells. What is the most likely diagnosis?

A. Hirschsprung disease
B. Meconium ileus
C. Intussusception
D. Cystic fibrosis
E. Volvulus
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 50-year-old man with multiple cutaneous lesions presents with recurrent episodes of abdominal pain and iron deficiency anemia. The provided image was obtained. What is the MOST appropriate next step in management?

A. Colonoscopy with polypectomy
B. Initiation of high-dose corticosteroids
C. Surgical resection of the affected bowel segment
D. Observation with serial abdominal exams
E. Empiric treatment for Helicobacter pylori
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A 45-year-old woman presents to her general practitioner with a 3-month history of epigastric pain that is worse at night and occasionally wakes her from sleep. She describes the pain as a burning sensation that improves with food intake but worsens a few hours after eating. She denies any weight loss, vomiting, or changes in bowel habits. She has a history of intermittent use of ibuprofen for chronic back pain. On examination, she appears well-nourished, with normal vital signs and mild epigastric tenderness on palpation. A urea breath test is positive. What is the most appropriate initial management for this patient?

A. Start a proton pump inhibitor and schedule a follow-up in 4 weeks
B. Initiate a proton pump inhibitor and eradicate Helicobacter pylori with a combination antibiotic therapy
C. Prescribe a histamine-2 receptor antagonist and advise discontinuation of ibuprofen
D. Refer for an upper gastrointestinal endoscopy to confirm the diagnosis
E. Recommend dietary modifications and prescribe antacids as needed
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 70-year-old male with cirrhosis secondary to NAFLD presents for routine surveillance. A new 3 cm lesion was found in segment VIII on ultrasound, with AFP 45. Contrast-enhanced ultrasound was performed, with representative images shown. Considering the clinical context and the findings demonstrated, what is the most appropriate immediate next step in this patient's management?

A. Schedule repeat surveillance ultrasound in 3 months.
B. Referral to a multidisciplinary liver tumour board for staging and treatment planning.
C. Referral for immediate liver transplantation assessment.
D. Proceed directly to percutaneous biopsy of the lesion.
E. Initiate systemic therapy with a tyrosine kinase inhibitor.
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Giant hiatal hernia, CT image. 63 year old man.
Image by Jmarchn CC BY 4.0 · Source

A 63-year-old man presents to his GP with a 6-month history of intermittent postprandial fullness and mild dysphagia, particularly with solid foods. He reports occasional regurgitation but denies significant heartburn or chest pain. His vital signs are stable, and physical examination is unremarkable. Recent blood tests show mild iron deficiency anaemia. The provided image is from a CT scan of the chest and upper abdomen performed as part of his investigation. Considering the clinical presentation and the significant anatomical finding demonstrated in the image, what is the most appropriate next step in the management of this patient?

A. Urgent upper gastrointestinal endoscopy to assess for malignancy.
B. Initiation of high-dose proton pump inhibitor therapy.
C. Prescription of iron supplements and dietary advice.
D. Barium swallow study to further characterise the anatomy.
E. Referral for surgical assessment and consideration of operative repair.
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