hyperparathyroidism

Practice targeted AMC-style multiple-choice questions on hyperparathyroidism.

CT, ultrasonography, SPECT and scintigraphy of intra-thyroid parathyroid adenoma

Image by Mnahi Bin Saeedan, Ibtisam Musallam Aljohani, Ayman Omar Khushaim, Salwa Qasim Bukhari, Salahudin Tayeb Elnaas — CC BY 4.0 · Source

A 62-year-old woman presents to her general practitioner complaining of fatigue, bone pain, and constipation for the past several months. She denies any significant past medical history. Initial laboratory investigations reveal an elevated serum calcium level of 3.1 mmol/L (reference range: 2.1-2.6 mmol/L) and an elevated parathyroid hormone (PTH) level of 180 pg/mL (reference range: 10-65 pg/mL). A 24-hour urine calcium excretion is also elevated. The patient is referred for further imaging, the results of which are shown. Based on the available information, what is the MOST appropriate next step in the management of this patient?

A. Initiate medical management with cinacalcet

B. Prescribe bisphosphonates for bone pain

C. Repeat serum calcium and PTH in 3 months

D. Parathyroidectomy

E. Refer for genetic testing for multiple endocrine neoplasia syndromes

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Image by Mnahi Bin Saeedan, Ibtisam Musallam Aljohani, Ayman Omar Khushaim, Salwa Qasim Bukhari, Salahudin Tayeb Elnaas — CC BY 4.0 · Source

A 62-year-old woman presents to her general practitioner complaining of fatigue, bone pain, and constipation for the past several months. She denies any significant past medical history. Her vital signs are stable. Initial laboratory investigations reveal an elevated serum calcium level of 3.1 mmol/L (reference range: 2.1-2.6 mmol/L) and an elevated parathyroid hormone (PTH) level of 180 pg/mL (reference range: 10-65 pg/mL). A 24-hour urine calcium excretion is also elevated. The patient is referred for further imaging, the results of which are shown. Based on the available information, what is the MOST appropriate next step in the management of this patient?

A. Initiate medical management with cinacalcet

B. Repeat serum calcium and PTH in 3 months

C. Order a bone mineral density scan

D. Surgical parathyroidectomy

E. Refer for genetic testing for multiple endocrine neoplasia

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Image by Mnahi Bin Saeedan, Ibtisam Musallam Aljohani, Ayman Omar Khushaim, Salwa Qasim Bukhari, Salahudin Tayeb Elnaas — CC BY 4.0 · Source

A 62-year-old woman presents to her general practitioner complaining of fatigue, bone pain, and constipation for the past several months. She denies any significant past medical history and is on no regular medications. Physical examination is unremarkable, and vital signs are within normal limits. Initial laboratory investigations reveal an elevated serum calcium level of 3.1 mmol/L (reference range: 2.1-2.6 mmol/L) and an elevated parathyroid hormone (PTH) level of 180 pg/mL (reference range: 10-65 pg/mL). A 24-hour urine calcium excretion is also elevated. The patient is referred for further imaging, the results of which are shown. Based on the available information, what is the MOST appropriate next step in the definitive management of this patient?

A. Long-term medical management with cinacalcet

B. Parathyroidectomy

C. Dietary calcium restriction

D. Bisphosphonate therapy

E. Repeat imaging studies in 6 months

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hyperparathyroidism

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