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gynecomastia

Practice targeted AMC-style multiple-choice questions on gynecomastia.

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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old man presents to his general practitioner with a six-month history of bilateral breast tenderness and swelling. He is otherwise asymptomatic, reporting no nipple discharge, skin changes, or palpable lumps. His medical history includes well-controlled hypertension on amlodipine. He denies illicit drug use or significant alcohol intake. On examination, the finding shown in the image is noted. Given this presentation, what is the most appropriate initial diagnostic step?

A. Advise lifestyle modification and review in three months.
B. Serum hormonal profile including testosterone, oestradiol, LH, FSH, prolactin, and hCG.
C. Referral for surgical consultation and potential biopsy.
D. Bilateral diagnostic mammography to rule out malignancy.
E. Ultrasound examination of the breast and axillary lymph nodes.
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old man presents to his general practitioner expressing concern about the appearance of his chest, which he feels has become more prominent over the past 18 months. He denies any pain, tenderness, or nipple discharge. His medical history includes well-controlled hypertension managed with perindopril and occasional use of ibuprofen for mild osteoarthritis. He reports no significant changes in weight, appetite, or energy levels. He is a non-smoker and drinks alcohol socially, approximately 5 standard drinks per week. He works as an accountant and reports no exposure to unusual chemicals or substances. On physical examination, his vital signs are within normal limits. Abdominal examination reveals no hepatosplenomegaly. Testicular examination is normal in size and consistency, with no palpable masses. The image provided shows the appearance of his chest. Considering the patient's presentation and the visual finding, what is the most appropriate initial investigation to pursue?

A. Genetic testing for Klinefelter syndrome.
B. Serum levels of testosterone, luteinising hormone (LH), follicle-stimulating hormone (FSH), oestradiol, and prolactin.
C. Liver function tests and renal function tests.
D. Mammography of the chest to assess for underlying malignancy.
E. Referral for psychological assessment and counselling regarding body image concerns.
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old male presents to his GP complaining of bilateral breast tenderness and swelling over the past 6 months. He denies nipple discharge, weight changes, or other systemic symptoms. His vital signs are normal. He takes no regular medications. Considering the clinical presentation and the provided image, which of the following investigations is the most appropriate initial step in evaluating this patient?

A. Chest X-ray
B. Bilateral mammography
C. Fine needle aspiration biopsy
D. Serum testosterone, oestradiol, LH, and FSH
E. Liver function tests and renal function tests
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old male presents to his GP complaining of bilateral breast tenderness and swelling over the past six months. He denies nipple discharge, weight changes, or other systemic symptoms. His past medical history is unremarkable, and he takes no regular medications. Physical examination reveals the findings shown in the image. His vital signs are within normal limits. Considering the most likely underlying cause suggested by the clinical presentation and image, which of the following is the most appropriate initial investigation?

A. Fine needle aspiration of the breast tissue
B. Chest X-ray
C. Mammography
D. Liver function tests and renal function tests
E. Serum testosterone, LH, FSH, estradiol, and prolactin levels
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 48-year-old man presents with a 2-year history of progressive, tender breast enlargement causing significant distress. Initial investigations including liver function tests, renal function tests, and basic hormonal assays (LH, FSH, testosterone, oestradiol) were largely within normal limits, except for a mildly elevated oestradiol. He takes no regular medications and denies recreational drug use. He is otherwise well and his physical examination is unremarkable apart from the findings shown in the image. Considering the clinical presentation and the findings, what is the most appropriate next step in his management?

A. Order a CT scan of the abdomen and pelvis to exclude occult malignancy.
B. Initiate a trial of tamoxifen for 3-6 months.
C. Reassure the patient that this is benign and requires no further intervention.
D. Referral to a plastic or general surgeon for consideration of reduction mammoplasty.
E. Repeat hormonal assays including prolactin and hCG.
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 62-year-old man presents with a 4-month history of bilateral breast enlargement and tenderness. He denies weight loss, fever, or changes in bowel habit. His medical history includes hypertension managed with amlodipine. On examination, vital signs are stable. The physical findings are demonstrated in the image. There is no palpable testicular mass. Given the clinical presentation and the findings shown, which of the following investigations is the most appropriate initial step to determine the underlying cause?

A. Mammography of both breasts
B. Fine needle aspiration of the breast tissue
C. Serum testosterone, oestradiol, LH, FSH, prolactin, and hCG
D. Trial of tamoxifen
E. Liver function tests and renal function tests
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old male presents with concerns about breast enlargement over the past year. He denies pain or nipple discharge. He takes no medications and has no known medical conditions. Examination reveals the findings in the image. What is the MOST appropriate initial investigation?

A. Reassurance and observation
B. Mammogram
C. Liver function tests
D. Prolactin level
E. Serum testosterone and estradiol levels
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old male presents with concerns about breast enlargement over the past year. He denies pain or nipple discharge. He takes no medications and reports no significant past medical history. Examination reveals the findings in the image. What is the MOST appropriate initial investigation?

A. Liver function tests
B. Prolactin level
C. Mammography
D. Serum testosterone and estradiol levels
E. Fine needle aspiration
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old man presents with concerns about breast enlargement over the past year. He denies pain or nipple discharge. He takes medication for hypertension. Examination reveals the findings in the image. Which of the following is the MOST appropriate initial investigation?

A. Review medication list and consider alternative antihypertensive
B. Reassurance and observation
C. Fine needle aspiration of breast tissue
D. Serum prolactin and testosterone levels
E. Mammogram and ultrasound of the breasts
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old man presents with concerns about breast enlargement. Examination reveals the findings in the image. Which of the following is the MOST appropriate initial investigation?

A. Liver function tests
B. Medication review
C. Serum prolactin
D. Mammogram
E. Testicular ultrasound
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 62-year-old man presents with bilateral breast enlargement, as shown. He denies pain or nipple discharge. What is the MOST likely underlying cause?

A. Liver cirrhosis
B. Medication side effect
C. Hyperthyroidism
D. Klinefelter syndrome
E. Testicular cancer
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 62-year-old male presents with bilateral breast enlargement for 6 months. He denies pain, discharge, or skin changes. He reports taking saw palmetto for BPH. Examination reveals the findings in the image. What is the MOST likely cause?

A. Hyperthyroidism
B. Testicular cancer
C. Cirrhosis
D. Idiopathic
E. Medication side effect
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old male presents to his GP with bilateral breast tenderness and swelling over six months. He denies nipple discharge or other systemic symptoms. Past medical history is unremarkable, and he takes no regular medications. Physical examination reveals the findings shown in the image. Vital signs are normal. Initial investigations including liver function tests, renal function tests, thyroid function tests, LH, FSH, prolactin, and testosterone are all within normal limits. Considering the clinical presentation, image findings, and normal initial investigations, which of the following is the most appropriate next step in the evaluation of this patient?

A. CT scan of the chest, abdomen, and pelvis
B. Referral for genetic testing for Klinefelter syndrome
C. Breast ultrasound and mammography
D. Initiate a trial of tamoxifen
E. Scrotal ultrasound
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old male presents with bilateral breast tenderness and swelling. He denies nipple discharge or systemic symptoms. His vitals are normal, and he takes no medications. Considering the clinical presentation and the findings depicted, which hormonal imbalance is most commonly implicated in the development of this condition in a male of this age group?

A. Excessive secretion of cortisol
B. Elevated serum prolactin
C. Increased oestrogen to testosterone ratio
D. Isolated deficiency of luteinising hormone
E. Primary hyperthyroidism
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old man presents with the condition shown. He reports taking spironolactone for hypertension. What is the MOST appropriate next step?

A. Refer to endocrinology for hormonal evaluation
B. Initiate treatment with tamoxifen
C. Order a mammogram to rule out malignancy
D. Review and potentially adjust his antihypertensive medication
E. Reassure the patient that this is a normal age-related change
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old man presents with concerns about breast enlargement over the past year. He denies pain or tenderness. He takes medication for hypertension. Examination reveals the findings in the image. Which of the following is the MOST appropriate initial investigation?

A. Mammogram and ultrasound
B. Medication review and hormonal blood tests (testosterone, estradiol, LH, FSH)
C. Reassurance and observation
D. Referral to a breast surgeon
E. Fine needle aspiration
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old male presents to his GP complaining of bilateral breast enlargement over the past year. He denies any pain or tenderness. He takes no medications and reports no significant past medical history. Examination reveals the findings in the image. What is the MOST appropriate initial investigation?

A. Prolactin level
B. Liver function tests
C. Fine needle aspiration
D. Serum testosterone and estradiol levels
E. Mammography
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