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jaundice

Practice targeted AMC-style multiple-choice questions on jaundice.

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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 62-year-old male with a history of hepatitis C presents with new onset jaundice and ascites. His AFP is markedly elevated. A contrast-enhanced ultrasound is performed, as shown. What is the MOST appropriate next step in management?

A. Initiate systemic chemotherapy
B. Referral for liver transplant evaluation
C. Order a triple-phase CT scan of the abdomen
D. Perform a percutaneous liver biopsy
E. Start sorafenib therapy
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 62-year-old presents with jaundice and RUQ pain. The image was obtained during ERCP. What is the MOST appropriate next step?

A. Observation with serial LFTs
B. Ursodeoxycholic acid administration
C. Sphincterotomy and stone extraction
D. Cholecystectomy
E. Percutaneous transhepatic cholangiography
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male with a history of chronic hepatitis C presents with right upper quadrant pain, weight loss, and jaundice. Vital signs are stable. Physical examination reveals hepatomegaly and mild ascites. Laboratory investigations include elevated alpha-fetoprotein (AFP). Imaging is performed as shown. Considering the clinical context and the findings demonstrated in the imaging, which of the following assessments is MOST crucial for determining the feasibility and type of definitive treatment for the identified lesion?

A. Confirmation of hepatitis C viral load
B. Assessment of underlying liver synthetic function (e.g., Child-Pugh score)
C. Evaluation for extrahepatic metastatic disease
D. Assessment of portal vein patency
E. Measurement of the lesion's maximum diameter
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 68-year-old woman presents to the emergency department with a 2-day history of worsening right upper quadrant abdominal pain radiating to her back, associated with fever, chills, and yellowing of her eyes. She denies prior similar episodes but reports occasional post-prandial discomfort. On examination, she is jaundiced and tender in the right upper quadrant. Vital signs are: temperature 38.5°C, heart rate 110 bpm, blood pressure 110/70 mmHg, respiratory rate 20 breaths per minute, and oxygen saturation 97% on room air. Initial laboratory investigations reveal: white blood cell count 14,000/µL, total bilirubin 6.0 mg/dL, alkaline phosphatase 450 U/L, ALT 300 U/L, and AST 250 U/L. An ERCP is performed, and the image is obtained. Following successful intervention to relieve the obstruction, the patient's symptoms begin to improve. Considering the likely underlying cause of this presentation and the findings during the procedure, what is the MOST appropriate next step in managing this patient's condition?

A. Referral for medical dissolution therapy for gallstones
B. Elective laparoscopic cholecystectomy during the same admission or shortly after discharge
C. Long-term antibiotic therapy to prevent recurrence
D. Discharge home with pain relief and follow-up in general practice
E. Repeat ERCP in 3 months to check for residual stones
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male presents to the emergency department with right upper quadrant abdominal pain, weight loss, and increasing jaundice over the past month. He has a history of chronic hepatitis C infection and heavy alcohol use. His vital signs are stable. Physical examination reveals hepatomegaly and mild ascites. Laboratory investigations show elevated bilirubin, alkaline phosphatase, and gamma-glutamyl transferase (GGT). Alpha-fetoprotein (AFP) is significantly elevated. A CT scan of the abdomen with and without contrast is performed, as shown. Based on the clinical presentation and imaging findings, what is the MOST appropriate next step in management?

A. Administration of intravenous antibiotics for suspected cholangitis
B. Percutaneous liver biopsy for histological confirmation
C. Initiation of antiviral therapy for hepatitis C
D. Surgical resection of the identified lesion
E. Referral to a hepatologist for consideration of liver transplantation
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 68-year-old woman presents to the emergency department with right upper quadrant abdominal pain, fever, and jaundice. Her vital signs are: temperature 38.5°C, heart rate 110 bpm, blood pressure 110/70 mmHg, respiratory rate 20 breaths per minute, and oxygen saturation 97% on room air. Initial laboratory investigations reveal: white blood cell count 14,000/µL, total bilirubin 6.0 mg/dL, alkaline phosphatase 450 U/L, ALT 300 U/L, and AST 250 U/L. An ERCP is performed, and the image is obtained. Following successful intervention, what is the MOST appropriate next step in managing this patient's condition?

A. Continue intravenous antibiotics and perform a percutaneous cholecystostomy tube placement.
B. Observe the patient without antibiotics and schedule an outpatient laparoscopic cholecystectomy in 6-8 weeks.
C. Administer intravenous antibiotics and schedule a laparoscopic cholecystectomy during the same admission.
D. Discharge the patient home with oral antibiotics and schedule an outpatient laparoscopic cholecystectomy.
E. Perform an open cholecystectomy during the same admission.
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A 55-year-old farmer presents with a week of severe retro-orbital headache, fever, and myalgia. He reports recent exposure to birthing sheep on his property. On examination, he is febrile (39.5°C) and mildly jaundiced. Liver enzymes are elevated (ALT 250 U/L). Chest X-ray is clear. What is the most likely diagnosis?

A. Leptospirosis
B. Viral hepatitis A
C. Influenza
D. Brucellosis
E. Q fever
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 70-year-old male presents with jaundice and abdominal distension. The provided image was obtained. What is the MOST likely underlying cause of the jaundice?

A. Choledocholithiasis
B. Intrahepatic cholestasis
C. Primary sclerosing cholangitis
D. Gilbert's syndrome
E. Pancreatic head mass
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 70-year-old male with known gastric MANEC presents with worsening jaundice and ascites. The provided CT scan was performed. Which of the following serum markers would be MOST useful in monitoring disease progression in this patient?

A. Amylase
B. Chromogranin A
C. CEA
D. Alpha-fetoprotein
E. CA 19-9
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 62-year-old male presents with jaundice and right upper quadrant pain. Initial labs show elevated bilirubin and alkaline phosphatase. An ERCP is performed, and the image is obtained. What is the MOST appropriate next step in management?

A. Percutaneous transhepatic biliary drainage
B. Cholecystectomy
C. Sphincterotomy and stone extraction
D. Observation with serial liver function tests
E. Ursodeoxycholic acid administration
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 72-year-old presents with acute cholangitis (fever, jaundice, RUQ pain). LFTs show obstructive pattern. ERCP is performed for biliary decompression and stone extraction. Following successful cannulation and cholangiography, the image is obtained. Based on the findings demonstrated in the image, what is the most appropriate immediate next step during this procedure?

A. Terminate the procedure and schedule surgery
B. Attempt stone extraction with a balloon catheter
C. Administer intravenous antibiotics and observe
D. Perform a sphincterotomy
E. Insert a biliary stent
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male presents to the emergency department with right upper quadrant abdominal pain, weight loss, and jaundice. He has a known history of chronic hepatitis C infection. His vital signs are stable. Physical examination reveals hepatomegaly and mild ascites. The patient denies any alcohol consumption. Laboratory investigations reveal elevated alpha-fetoprotein (AFP) levels. A CT scan of the abdomen with and without contrast is performed, as shown. Based on the imaging and clinical findings, what is the MOST appropriate next step in management?

A. Referral to a hepatologist for consideration of liver transplantation
B. Percutaneous liver biopsy for histological confirmation
C. Observation with serial AFP measurements every 3 months
D. Administration of intravenous antibiotics for suspected cholangitis
E. Initiation of antiviral therapy for hepatitis C
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male with a history of chronic hepatitis C presents with right upper quadrant pain, weight loss, and jaundice. Physical examination reveals hepatomegaly and mild ascites. Laboratory investigations include elevated alpha-fetoprotein (AFP) levels. Imaging is performed as shown. Considering the clinical context and the findings demonstrated in the imaging, which of the following factors is MOST critical in determining this patient's eligibility for potentially curative surgical resection?

A. Absolute value of serum alpha-fetoprotein
B. Genotype of hepatitis C virus
C. Tumour size and number
D. Patient's chronological age
E. Presence of clinically significant portal hypertension
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 68-year-old presents with a 3-day history of fever, jaundice, and severe RUQ pain radiating to the back. Vitals: T 38.5°C, BP 110/70, HR 95. LFTs show bilirubin 150, ALP 450, ALT 120. An ERCP is performed for stone extraction. The image is captured during the procedure after cannulation. Considering the findings demonstrated in the image, what is the most appropriate immediate next step in management during the current procedure?

A. Attempt balloon dilation of the distal duct without sphincterotomy
B. Place a biliary stent and schedule follow-up ERCP
C. Perform endoscopic sphincterotomy
D. Attempt stone fragmentation with lithotripsy before sphincterotomy
E. Abandon the procedure and refer for surgical exploration
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 62-year-old male with a history of hepatitis C presents with new onset jaundice and abdominal distension. Ascites is confirmed on examination. The patient denies alcohol use. An ultrasound with contrast is performed, as shown. What is the MOST appropriate next step in management?

A. Referral for liver transplant evaluation
B. Order a triple-phase CT scan of the abdomen
C. Initiate empiric antibiotic therapy for spontaneous bacterial peritonitis
D. Administer intravenous albumin and diuretics
E. Paracentesis for diagnostic and therapeutic purposes
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 62-year-old male presents with jaundice and RUQ pain. An ERCP is performed, and the image is obtained. Following successful stone extraction, what is the MOST appropriate next step in managing this patient?

A. Sphincteroplasty
B. Ursodeoxycholic acid
C. Observation with serial LFTs
D. Percutaneous cholecystostomy
E. Cholecystectomy
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 68-year-old presents with a 3-day history of fever, jaundice, and severe RUQ pain radiating to the back. Vitals: T 38.5°C, BP 110/70, HR 95. LFTs show bilirubin 150, ALP 450, ALT 120. An ERCP is performed for stone extraction. The image is captured during the procedure after cannulation. Considering the findings demonstrated in the image, what is the most appropriate immediate next step in management during the current procedure?

A. Proceed with mechanical lithotripsy after sphincterotomy.
B. Place a biliary stent for decompression.
C. Attempt extraction with a balloon catheter after sphincterotomy.
D. Refer for urgent laparoscopic common bile duct exploration.
E. Terminate the procedure and manage medically.
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 72-year-old woman presents with a 2-day history of worsening right upper quadrant pain radiating to her back, associated with nausea and a low-grade fever. On examination, she is jaundiced and has tenderness in the right upper quadrant. Laboratory tests show a total bilirubin of 75 µmol/L, ALP 350 U/L, ALT 200 U/L, and WCC 13.5 x 10^9/L. An urgent ERCP is performed, during which the image is captured. Following successful endoscopic clearance and clinical improvement, which of the following is the MOST appropriate long-term management strategy?

A. Long-term treatment with ursodeoxycholic acid
B. Repeat ERCP with cholangiogram in 3 months
C. Regular monitoring of liver function tests every 6 months
D. Strict adherence to a low-fat diet
E. Elective laparoscopic cholecystectomy
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 68-year-old woman presents to the emergency department with right upper quadrant abdominal pain, fever, and jaundice. Her past medical history is significant for hypertension and hyperlipidemia. Initial laboratory investigations reveal elevated bilirubin, alkaline phosphatase, and gamma-glutamyl transferase (GGT) levels. An ultrasound of the abdomen showed dilated intrahepatic ducts, but the common bile duct was difficult to visualize due to overlying bowel gas. An ERCP was performed, and an image obtained during the procedure is shown. Following successful removal of the obstruction, what is the MOST appropriate next step in managing this patient's condition?

A. Prescribe oral ursodeoxycholic acid
B. Schedule a laparoscopic cholecystectomy
C. Administer intravenous antibiotics and monitor liver function tests
D. Perform a percutaneous transhepatic cholangiogram
E. Discharge the patient with instructions for a low-fat diet
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 62-year-old woman presents with right upper quadrant pain, fever, and jaundice. Initial labs show elevated bilirubin and alkaline phosphatase. An ERCP is performed, and the image is obtained. What is the MOST appropriate next step in management?

A. Ursodeoxycholic acid administration
B. Cholecystectomy
C. Observation with serial liver function tests
D. Sphincterotomy and stone extraction
E. Percutaneous transhepatic biliary drainage
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