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middle-aged man

Practice targeted AMC-style multiple-choice questions on middle-aged man.

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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 55-year-old man with a history of renal transplant on long-term immunosuppressive therapy presents with a 3-month history of intermittent right upper quadrant pain and unintentional weight loss. He denies fever or chills. Physical examination is unremarkable. Liver function tests show mild elevation of alkaline phosphatase and gamma-GT. Inflammatory markers (CRP, ESR) are slightly elevated. Imaging is performed as shown. Based on the findings and clinical context, what is the most appropriate next diagnostic step?

A. Repeat CT scan with intravenous contrast
B. Liver biopsy of the lesion
C. Percutaneous drainage and culture of the lesion
D. Serological testing for Echinococcus species
E. Empirical broad-spectrum antibiotic therapy
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A 55-year-old man, non-smoker, presents for a health check. BP 135/85 mmHg, total cholesterol 5.5 mmol/L, HDL 1.2 mmol/L. No personal history of CVD or diabetes. Family history of premature CVD in father. BMI 28. Based on Australian guidelines, what is the most appropriate initial management step?

A. Order a fasting glucose and HbA1c.
B. Start perindopril 5mg daily.
C. Start atorvastatin 20mg daily.
D. Calculate absolute cardiovascular risk and discuss lifestyle modification.
E. Advise weight loss and recheck BP in 6 months.
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 45-year-old male presents with intermittent abdominal pain and melena. The provided image was obtained. What is the most likely underlying cause?

A. Henoch-Schönlein purpura
B. Cystic fibrosis
C. Meckel's diverticulum
D. Peutz-Jeghers syndrome
E. Blue rubber bleb nevus syndrome
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Inguinal hernia right view. Adult male with an inguinal hernia, showing bulging in the groin area.
Image by IkeTheSloth CC0 1.0 · Source

A 55-year-old male presents to his GP complaining of a swelling in his right groin that has been present for several months. He states it is more noticeable when he is standing or coughing and sometimes causes a dull ache, but it is easily pushed back in when he lies down. He denies any fever, nausea, or acute pain. His vital signs are stable. Physical examination reveals the finding shown in the image. Considering the patient's history and the physical examination finding depicted, what is the most appropriate next step in management?

A. Recommend a trial of a supportive truss garment.
B. Referral for elective surgical repair.
C. Request an urgent ultrasound of the groin.
D. Advise watchful waiting and provide analgesia as needed.
E. Immediate surgical consultation for suspected incarceration.
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A 67-year-old man with a history of type 2 diabetes mellitus and hypertension presents to the emergency department with sudden onset of right-sided weakness and slurred speech that began 2 hours ago. He has no history of atrial fibrillation or previous strokes. On examination, his blood pressure is 180/95 mmHg, heart rate is 88 bpm, and he is afebrile. Neurological examination reveals right-sided hemiparesis and expressive aphasia. A non-contrast CT scan of the head shows no evidence of hemorrhage. Which of the following is the most appropriate next step in the management of this patient?

A. Perform a CT angiogram of the head and neck
B. Administer intravenous labetalol to lower blood pressure
C. Intravenous thrombolysis with alteplase
D. Refer for urgent carotid endarterectomy
E. Start aspirin therapy
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A 58-year-old man presents to the emergency department with chest pain radiating to his left arm. His ECG shows ST-segment elevation in leads II, III, and aVF. What is the most appropriate immediate management?

A. Administer thrombolytic therapy
B. Perform an echocardiogram to assess cardiac function
C. Administer sublingual nitroglycerin and observe
D. Start intravenous heparin and admit to the coronary care unit
E. Administer aspirin and initiate primary percutaneous coronary intervention (PCI)
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A 60-year-old man with a Popeye deformity has no pain but reports mild weakness in supination. What is the most appropriate management?

A. Surgical repair
B. NSAIDs
C. Corticosteroid injection
D. Observation
E. Physical therapy
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A 45-year-old weightlifter presents with sudden pain and a bulge in his arm after lifting a heavy weight. On examination, there is a Popeye deformity. What is the most likely mechanism of injury?

A. Traumatic rupture of the biceps tendon.
B. Degenerative tear
C. Inflammatory tendinitis
D. Repetitive overhead activity
E. Nerve compression
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Inguinal hernia right view. Adult male with an inguinal hernia, showing bulging in the groin area.
Image by IkeTheSloth CC0 1.0 · Source

A 45-year-old man presents with a bulge in his right groin that he noticed a few weeks ago. It's more prominent when he coughs or strains. Examination reveals the finding in the image. He denies pain. What is the MOST likely diagnosis?

A. Hydrocele
B. Lipoma
C. Indirect inguinal hernia
D. Direct inguinal hernia
E. Femoral hernia
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A 40-year-old man presents with fever, pleuritic chest pain, and cough. A chest X-ray shows a pleural effusion. What is the next step in management?

A. Start steroids.
B. Perform a thoracentesis.
C. Start antibiotics.
D. Observe and repeat imaging in 2 weeks.
E. Order a CT scan.
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 38-year-old man presents with sudden onset severe left flank pain radiating to the groin, associated with nausea. He is afebrile, blood pressure 140/90 mmHg, heart rate 95 bpm. Urinalysis shows microscopic haematuria. Serum creatinine is 80 µmol/L. An ultrasound is performed. Considering the clinical presentation and the findings demonstrated in the provided image, which of the following best explains the mechanism of the patient's pain?

A. Spasm of the renal artery
B. Increased pressure within the renal pelvis and collecting system
C. Ischaemia of the renal medulla
D. Distension of the renal capsule due to oedema
E. Inflammation of the renal parenchyma
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A 50-year-old Aboriginal man presents for a routine check-up. He has a strong family history of type 2 diabetes. What is the most appropriate initial screening test?

A. Fasting blood glucose
B. Oral glucose tolerance test
C. HbA1c
D. Random blood glucose
E. Urine glucose
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 62-year-old male presents with LLQ pain and fever. The provided image was obtained. What is the most appropriate initial management?

A. Surgical consultation for possible resection
B. Oral antibiotics and outpatient follow-up
C. Colonoscopy to rule out malignancy
D. Stool culture to rule out infectious colitis
E. IV antibiotics and admission for observation
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A 55-year-old farmer presents with a week of severe retro-orbital headache, fever, and myalgia. He reports recent exposure to birthing sheep on his property. On examination, he is febrile (39.5°C) and mildly jaundiced. Liver enzymes are elevated (ALT 250 U/L). Chest X-ray is clear. What is the most likely diagnosis?

A. Leptospirosis
B. Viral hepatitis A
C. Influenza
D. Brucellosis
E. Q fever
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A 60-year-old man presents to the emergency department with sudden onset of chest pain and shortness of breath. He has a history of chronic obstructive pulmonary disease (COPD) and is a current smoker. On examination, he is tachypneic and has decreased breath sounds on the right side. A chest X-ray reveals a large right-sided pneumothorax. What is the most appropriate initial management?

A. Start intravenous antibiotics
B. Insert a chest tube
C. Perform needle decompression
D. Administer high-flow oxygen
E. Order a CT scan of the chest
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 58-year-old male with cirrhosis secondary to alcohol abuse presents for routine surveillance. His AFP is 25 ng/mL. A contrast-enhanced ultrasound is performed, as shown. What is the MOST appropriate next step in management?

A. MRI of the abdomen with contrast
B. Repeat AFP in 3 months
C. CT of the abdomen with contrast
D. Liver biopsy
E. Initiate sorafenib
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A 45-year-old man presents to his GP with a 3-month history of gradually enlarging, painless swelling in the left side of his neck. He denies fever, night sweats, or weight loss. He emigrated from a region with high tuberculosis prevalence five years ago and has no known history of TB exposure or prior testing. On examination, there are multiple firm, non-tender, discrete lymph nodes in the left posterior triangle of the neck, the largest measuring about 3 cm. There are no other palpable nodes or organomegaly. His chest X-ray is clear. What is the most appropriate next diagnostic step?

A. Order a CT scan of the neck to assess the extent of lymphadenopathy
B. Fine needle aspiration cytology and mycobacterial culture of the affected lymph node
C. Perform an Interferon-gamma release assay (IGRA)
D. Initiate empirical treatment with a broad-spectrum antibiotic
E. Excisional biopsy of the largest lymph node for histopathology
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 45-year-old male presents with intermittent abdominal pain and melena. The provided image was obtained. What is the most appropriate next step in management?

A. Surgical resection of affected bowel segments
B. Perform colonoscopy to rule out other causes of bleeding
C. Initiate a trial of high-dose corticosteroids
D. Prescribe iron supplementation and monitor hemoglobin levels
E. Start empiric antibiotic therapy for suspected bacterial overgrowth
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A 35-year-old man presents with 3 weeks of anal pain after defecation, blood on wiping, and constipation (firm stool every 2-3 days). What is the likely diagnosis?

A. Perianal abscess
B. Anal skin tags.
C. Anal fissure
D. Fistula-in-ano
E. Haemorrhoids
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A 62-year-old male presents to the emergency department with a 2-day history of right flank pain, fever, and nausea. He reports a history of recurrent urinary tract infections. On examination, he has right costovertebral angle tenderness. Urinalysis reveals pyuria and leukocyte esterase. Which of the following is the most likely underlying condition related to the organ primarily affected in the right lumbar region?

A. Cholecystitis with referred pain
B. Appendicitis with atypical presentation
C. Musculoskeletal strain
D. Pyelonephritis secondary to ascending urinary tract infection
E. Diverticulitis of the ascending colon
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Inguinal hernia right view. Adult male with an inguinal hernia, showing bulging in the groin area.
Image by IkeTheSloth CC0 1.0 · Source

A 58-year-old male presents to the emergency department complaining of right groin pain that started approximately 6 hours ago. He reports noticing a bulge in his groin for several months, which he could usually push back in. However, today he is unable to reduce it, and the pain has become progressively severe. He denies any fever, nausea, or vomiting. His past medical history includes hypertension and hyperlipidemia, both well-controlled with medications. On examination, his vital signs are stable: blood pressure 130/80 mmHg, heart rate 80 bpm, respiratory rate 16 bpm, and temperature 37.0°C. Abdominal examination is benign. Examination of the groin reveals the finding shown in the image. The area is tender to palpation. Which of the following is the MOST appropriate next step in the management of this patient?

A. Surgical consultation for emergent repair
B. Ultrasound of the groin to rule out testicular torsion
C. Prescription for a truss and referral to a general surgeon for elective repair
D. CT scan of the abdomen and pelvis with intravenous contrast
E. Trial of manual reduction with sedation and analgesia
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male presents to the emergency department with right upper quadrant abdominal pain, weight loss, and jaundice. He has a known history of chronic hepatitis C infection. His vital signs are stable. Physical examination reveals hepatomegaly and mild ascites. The patient denies any alcohol consumption. Laboratory investigations reveal elevated alpha-fetoprotein (AFP) levels. A CT scan of the abdomen with and without contrast is performed, as shown. Based on the imaging and clinical findings, what is the MOST appropriate next step in management?

A. Referral to a hepatologist for consideration of liver transplantation
B. Percutaneous liver biopsy for histological confirmation
C. Observation with serial AFP measurements every 3 months
D. Administration of intravenous antibiotics for suspected cholangitis
E. Initiation of antiviral therapy for hepatitis C
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Synchronous multiple small bowel intussusceptions in an adult with blue rubber bleb naevus syndrome. CT scan of abdomen showing i) multiple intussusceptions demonstrating doughnut signs (white arrows), intussusceptiens [A], intussusceptum [B], distended loop of small

bowel [C] and ii) haemangioma of right quadratus lumborum muscle (dark arrow).
Image by Lee C, Debnath D, Whitburn T, Farrugia M, Gonzalez F CC BY 2.0 · Source

A 45-year-old male presents with intermittent abdominal pain and melena. He has multiple cutaneous hemangiomas. The provided image was obtained. What is the MOST likely underlying cause of the patient's presentation?

A. Peutz-Jeghers syndrome
B. Blue rubber bleb nevus syndrome
C. Gardner syndrome
D. Henoch-Schönlein purpura
E. Osler-Weber-Rendu syndrome
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A 56-year-old gentleman, a gardener and cat owner, presents with 24 hours of pain, swelling, and redness on his right index finger. His temperature is 38.1°C and pulse is 72. Suspected gout. What is the most appropriate next step?

A. Aspirate joint for microscopy and culture.
B. Urgent hospital referral for drainage and IV antibiotics.
C. Prescribe oral antibiotics and review in 24 hours.
D. Start diclofenac TDS and discuss allopurinol.
E. Order serum uric acid level.
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A 45-year-old farmer presents with a 10-day history of fever, severe retro-orbital headache, and myalgia. He denies cough or dyspnoea. Physical examination is unremarkable. What is the most appropriate initial investigation?

A. Liver function tests
B. Serology for Coxiella burnetii
C. Chest X-ray
D. Blood culture
E. PCR for Coxiella burnetii
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Giant hiatal hernia, CT image. 63 year old man.
Image by Jmarchn CC BY 4.0 · Source

A 63-year-old man presents to the ED with increasing shortness of breath and epigastric discomfort, particularly after meals. He has a history of well-controlled hypertension and takes no regular medications. Physical examination reveals decreased breath sounds at the left lung base. An abdominal CT scan is performed, the axial view is shown. What is the MOST appropriate next step in management?

A. Discharge with reassurance and follow-up with a gastroenterologist in 6 months
B. Barium swallow study to further evaluate the anatomy
C. Surgical consultation for elective repair
D. Initiate a trial of proton pump inhibitors and lifestyle modifications
E. Esophageal manometry to assess esophageal motility
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 50-year-old man presents with a slowly growing, asymptomatic nasal lesion. He reports no trauma or fever. Examination reveals the image shown. What is the MOST likely long-term outcome if left untreated?

A. Transformation to squamous cell carcinoma
B. Local tissue destruction
C. Metastatic spread
D. Spontaneous resolution
E. Development of systemic lupus erythematosus
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A 45-year-old man presents to the clinic with a 3-month history of persistent cough, night sweats, and weight loss. He has a history of smoking and works as a miner. On examination, he has decreased breath sounds and dullness to percussion over the right upper lobe. A chest X-ray shows a cavitary lesion in the right upper lobe. What is the most likely diagnosis?

A. Pulmonary tuberculosis
B. Chronic obstructive pulmonary disease (COPD)
C. Pneumonia
D. Lung cancer
E. Sarcoidosis
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 55-year-old male presents to the emergency department with a 2-day history of left lower quadrant abdominal pain, associated with a low-grade fever (38.1°C) and mild nausea. He denies vomiting, diarrhoea, or rectal bleeding. On examination, he has localised tenderness in the left iliac fossa. His vital signs are stable: BP 130/80 mmHg, HR 78 bpm, RR 16/min, SpO2 98% on air. Blood tests show a white cell count of 12.5 x 10^9/L and CRP 45 mg/L. An abdominal CT scan is performed (image provided). Based on the clinical presentation and the provided image, what is the most appropriate initial management plan?

A. Intravenous antibiotics and hospital admission for observation.
B. Urgent surgical consultation for Hartmann's procedure.
C. Immediate colonoscopy to evaluate the colonic mucosa.
D. Discharge with advice on dietary modification and follow-up in 6 weeks.
E. Outpatient oral antibiotics and analgesia.
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A 45-year-old Aboriginal man from a remote community presents to the clinic for a routine health check. He has a history of smoking (20 pack-years) and reports drinking alcohol occasionally (3-4 standard drinks per week). He denies any chronic medical conditions. His blood pressure is 145/95 mmHg. BMI is 32 kg/m2. Fasting blood glucose is 6.5 mmol/L. Which of the following is the MOST appropriate initial management strategy, considering the principles of culturally safe care?

A. Prescribe an antihypertensive medication (e.g., ACE inhibitor) and metformin to address the elevated blood pressure and glucose levels immediately.
B. Initiate lifestyle modification counseling, including smoking cessation, dietary advice, and encourage increased physical activity, while also arranging a follow-up appointment to reassess blood pressure and glucose levels.
C. Provide him with written information about hypertension and diabetes and instruct him to follow up with the clinic if he develops any symptoms.
D. Refer him to a specialist physician for further evaluation and management of his hypertension and pre-diabetes.
E. Advise him to reduce his alcohol consumption and schedule a follow-up appointment in six months to monitor his blood pressure and glucose levels.
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A 40-year-old patient with schizophrenia is started on risperidone. His GP recommends regular monitoring. What parameters should be monitored?

A. Serum calcium
B. Thyroid function tests
C. Liver function tests
D. Vitamin D levels
E. Blood glucose and lipids
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 62-year-old male presents with a 3-month history of rectal bleeding and altered bowel habits. Colonoscopy was performed, and a representative image is shown. What is the MOST appropriate next step in management?

A. Surgical resection
B. Initiate high-dose corticosteroids
C. Repeat colonoscopy in 1 year
D. Prescribe a high-fiber diet
E. Administer intravenous antibiotics
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A 55-year-old man with a history of hypertension and smoking presents for a routine check-up. He is concerned about his risk of cardiovascular disease and asks for advice on lifestyle modifications. Which of the following lifestyle changes would most significantly reduce his risk of cardiovascular events?

A. Adopting a Mediterranean diet
B. Smoking cessation
C. Increasing physical activity
D. Limiting alcohol consumption
E. Reducing dietary salt intake
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 40-year-old male presents with acute, severe left flank pain. An ultrasound is performed. What is the MOST likely underlying cause of the finding on the image?

A. Polycystic kidney disease
B. Renal cell carcinoma
C. Acute pyelonephritis
D. Ureteral obstruction
E. Renal vein thrombosis
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 35-year-old male presents with hemoptysis and weight loss. PET-CT is shown. Bronchoscopy with biopsy is MOST likely to reveal which of the following?

A. Adenocarcinoma in situ
B. Squamous cell carcinoma
C. Granulomatous inflammation with caseous necrosis
D. Small cell carcinoma
E. Mesothelioma
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 45-year-old male presents with a painless lesion on his nose that has been present for several months. He denies any trauma or recent illness. Examination reveals the image shown. What is the MOST appropriate initial management?

A. Observation with serial photography
B. Topical antifungal cream
C. Topical corticosteroid application
D. Biopsy for histopathological examination
E. Cryotherapy
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 55-year-old man presents to the emergency department with sudden onset, severe left flank pain radiating to his groin, associated with nausea. He is afebrile, blood pressure 130/80 mmHg, heart rate 85 bpm. Urinalysis shows 20-30 red blood cells per high-power field. Serum creatinine is within normal limits. An ultrasound is performed. Considering the clinical context and the findings demonstrated in the provided image, which of the following is the most appropriate immediate management step?

A. Initiate empirical broad-spectrum intravenous antibiotics.
B. Prescribe oral tamsulosin and diclofenac and discharge home.
C. Urgent urology consultation for potential decompression.
D. Administer intravenous fluids and opioid analgesia and observe for spontaneous stone passage.
E. Arrange a non-contrast CT KUB as the definitive imaging modality.
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 60-year-old man, post-chemotherapy, presents with fever and abdominal pain. The images are shown. What is the MOST appropriate initial therapy?

A. Surgical resection
B. Amphotericin B
C. Albendazole
D. Broad-spectrum antibiotics
E. Percutaneous drainage
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A 62-year-old man presents to the emergency department with a history of palpitations and dizziness that started suddenly 2 hours ago. He has a history of hypertension and is on lisinopril. He denies chest pain, shortness of breath, or syncope. On examination, his blood pressure is 110/70 mmHg, heart rate is 150 bpm (irregular), respiratory rate is 18 breaths per minute, and temperature is 36.7°C. An ECG is performed, showing an irregularly irregular rhythm with no distinct P waves and a narrow QRS complex. Which of the following is the most appropriate initial management step?

A. Initiation of anticoagulation therapy
B. Rate control with a beta-blocker
C. Immediate electrical cardioversion
D. Administration of adenosine
E. Rate control with digoxin
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A 45-year-old male presents to the emergency department with severe chest pain radiating to his left arm, shortness of breath, and diaphoresis. He has a history of hypertension and hyperlipidemia. On examination, he is diaphoretic, and his blood pressure is 90/60 mmHg. An ECG shows ST-segment elevation in leads II, III, and aVF. What is the most appropriate initial management for this patient?

A. Administer intravenous fluids to address hypotension
B. Administer beta-blockers to reduce myocardial oxygen demand
C. Administer morphine for pain management
D. Administer aspirin and initiate reperfusion therapy
E. Administer nitroglycerin for chest pain relief
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Ileitis terminalis bei langjaehrigem Morbus Crohn 63W - CT und MRT - 001
Image by Hellerhoff CC BY-SA 4.0 · Source

A 32-year-old male with a 10-year history of Crohn's disease presents with worsening abdominal pain and increased frequency of bowel movements. He reports no fever or weight loss. Physical examination reveals mild tenderness in the right lower quadrant. His inflammatory markers are elevated. Review the provided imaging. What is the MOST appropriate next step in management?

A. Initiate anti-TNF therapy
B. Perform a colonoscopy with biopsy
C. Recommend a low-FODMAP diet
D. Start a trial of antibiotics for possible infection
E. Prescribe a course of oral corticosteroids
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 45-year-old man presents to his GP with a lesion on his nose that he first noticed about 6 months ago. It has slowly increased in size but is not painful or itchy. He has no significant past medical history and takes no regular medications. On examination, vital signs are stable. The image shows the appearance of the lesion. Considering the clinical presentation and the appearance of the lesion shown, what is the most appropriate initial management step?

A. Reassure the patient and review in 3 months.
B. Excisional biopsy for histological assessment.
C. Prescribe a course of topical corticosteroid cream.
D. Refer immediately for Mohs micrographic surgery.
E. Arrange for cryotherapy in the clinic.
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the emergency department with sudden onset severe left flank pain radiating to the groin. He reports some nausea but no vomiting. His temperature is 37.5°C, pulse 88 bpm, BP 130/80 mmHg, respiratory rate 16/min, oxygen saturation 98% on room air. On examination, he has significant left costovertebral angle tenderness. Urinalysis shows microscopic haematuria and trace leukocytes. His creatinine is 90 µmol/L (baseline unknown). An ultrasound of the kidneys is performed, shown in the image. Considering the patient's presentation and the findings demonstrated in the provided image, the most likely primary mechanism responsible for the severe pain experienced by this patient is:

A. Ischaemic injury to the renal tubules resulting from compromised blood flow.
B. Increased hydrostatic pressure leading to distension of the renal pelvis and collecting system.
C. Reflex spasm of the psoas muscle due to ureteral irritation.
D. Direct irritation of sensory nerve endings in the ureteral wall by the obstructing object.
E. Inflammatory response within the renal parenchyma secondary to bacterial invasion.
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A 58-year-old farmer presents with a 10-day history of fever, severe retro-orbital headache, myalgia, and profound fatigue. He denies cough or sore throat. Examination reveals mild scleral icterus. Liver function tests show elevated transaminases. He works closely with sheep and cattle. What is the most likely diagnosis?

A. Influenza
B. Leptospirosis
C. Brucellosis
D. Viral hepatitis A
E. Q fever
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old male presents to his GP with bilateral breast tenderness and swelling over six months. He denies nipple discharge or other systemic symptoms. Past medical history is unremarkable, and he takes no regular medications. Physical examination reveals the findings shown in the image. Vital signs are normal. Initial investigations including liver function tests, renal function tests, thyroid function tests, LH, FSH, prolactin, and testosterone are all within normal limits. Considering the clinical presentation, image findings, and normal initial investigations, which of the following is the most appropriate next step in the evaluation of this patient?

A. CT scan of the chest, abdomen, and pelvis
B. Referral for genetic testing for Klinefelter syndrome
C. Breast ultrasound and mammography
D. Initiate a trial of tamoxifen
E. Scrotal ultrasound
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 58-year-old male, on chronic immunosuppressants, presents with vague abdominal pain. The images are shown. What is the MOST likely causative organism?

A. Klebsiella pneumoniae
B. Echinococcus multilocularis
C. Escherichia coli
D. Staphylococcus aureus
E. Entamoeba histolytica
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A 58-year-old man with a 10-year history of Type 2 diabetes presents to the clinic for a routine follow-up. He is currently on metformin and lifestyle modifications, but his HbA1c has increased to 8.5% over the past six months. He reports adherence to his medication and diet but has a sedentary lifestyle. What is the most appropriate next step in managing his diabetes?

A. Refer for bariatric surgery
B. Add a GLP-1 receptor agonist
C. Add a sulfonylurea
D. Increase the dose of metformin
E. Start basal insulin therapy
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Giant hiatal hernia, CT image. 63 year old man.
Image by Jmarchn CC BY 4.0 · Source

A 63-year-old man presents with increasing postprandial fullness and epigastric discomfort. A CT scan of the abdomen is performed. Based on the image, what is the MOST appropriate next step in management?

A. Initiate a trial of high-dose proton pump inhibitors
B. Esophageal manometry to assess esophageal motility
C. Surgical consultation for consideration of fundoplication
D. Reassurance and dietary modification
E. Barium swallow study to evaluate for esophageal strictures
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A 45-year-old man presents to the emergency department with sudden onset of severe chest pain radiating to his back. He describes the pain as tearing in nature. He has a history of hypertension and is a smoker. On examination, his blood pressure is 180/110 mmHg in the right arm and 160/100 mmHg in the left arm. His heart rate is 110 bpm, and he has a new diastolic murmur. An ECG shows left ventricular hypertrophy but no ischemic changes. What is the most appropriate next step in management?

A. Immediate thrombolysis
B. Chest X-ray
C. Echocardiography
D. Coronary angiography
E. CT angiography of the chest
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Giant hiatal hernia, CT image. 63 year old man.
Image by Jmarchn CC BY 4.0 · Source

A 63-year-old man presents to his GP with a 6-month history of intermittent postprandial fullness and mild dysphagia, particularly with solid foods. He reports occasional regurgitation but denies significant heartburn or chest pain. His vital signs are stable, and physical examination is unremarkable. Recent blood tests show mild iron deficiency anaemia. The provided image is from a CT scan of the chest and upper abdomen performed as part of his investigation. Considering the clinical presentation and the significant anatomical finding demonstrated in the image, what is the most appropriate next step in the management of this patient?

A. Urgent upper gastrointestinal endoscopy to assess for malignancy.
B. Initiation of high-dose proton pump inhibitor therapy.
C. Prescription of iron supplements and dietary advice.
D. Barium swallow study to further characterise the anatomy.
E. Referral for surgical assessment and consideration of operative repair.
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