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pediatrics

Practice targeted AMC-style multiple-choice questions on pediatrics.

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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 2-year-old child is brought to the GP by their parents who are concerned about the appearance of their child's abdomen. The child is asymptomatic, feeding well, and has no history of vomiting or pain. On examination, vital signs are normal. Considering the clinical presentation and the finding shown in the image, what is the most appropriate initial management?

A. Arrange an urgent abdominal ultrasound.
B. Urgent surgical referral for repair.
C. Application of an abdominal binder or tape.
D. Prescription of paracetamol and review in 3 months.
E. Observation and reassurance, advising review if symptomatic or persistent beyond age 4-5 years.
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A 28-year-old woman, 18 weeks pregnant, presents to her GP two days after her 5-year-old son developed varicella. She is unsure of her immunity status and is asymptomatic. Which of the following is the most appropriate initial management step?

A. Observe closely for symptoms and treat with acyclovir if rash develops.
B. Reassure her that the risk is low given she is asymptomatic.
C. Administer varicella vaccine.
D. Obtain urgent varicella serology and administer VZIG if non-immune.
E. Administer varicella-zoster immunoglobulin (VZIG) as soon as possible.
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A 7-year-old boy with a history of asthma presents to the clinic with increased wheezing and shortness of breath over the past week. He has been using his salbutamol inhaler more frequently, but his symptoms persist. His mother reports that he has been waking up at night due to coughing. What is the most appropriate next step in managing this child's asthma?

A. Prescribe an oral corticosteroid
B. Add a long-acting beta-agonist
C. Start an inhaled corticosteroid
D. Refer to a pulmonologist
E. Increase the dose of salbutamol
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A 7-year-old boy is brought to the emergency department by his parents due to sudden onset wheezing and difficulty breathing. He has a history of asthma, for which he uses a salbutamol inhaler as needed. His parents report that he had a cold over the past few days, and today he started wheezing and became short of breath. On examination, he is in moderate respiratory distress, with a respiratory rate of 30 breaths per minute, oxygen saturation of 92% on room air, and widespread wheezing on auscultation. What is the most appropriate initial management step for this child?

A. Administer nebulized salbutamol
B. Provide supplemental oxygen
C. Initiate inhaled corticosteroids
D. Start oral corticosteroids
E. Administer intravenous magnesium sulfate
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A 10-year-old boy is brought to the GP by his parents, who report difficulties with attention and hyperactivity at school and home for the past 6 months. Which of the following is the MOST appropriate initial step in managing this child?

A. Referral to a paediatrician or child psychiatrist for comprehensive assessment
B. Initiation of a trial of stimulant medication
C. Advising the parents to implement stricter discipline at home
D. Recommending behavioural therapy alone
E. Suggesting dietary changes, such as eliminating sugar
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An ultrasound showing target sign which is a characteristic finding for intussusception on ultrasound, this ultrasound is for a 3 year old boy with intestinal intussusception.
Image by Frank Gaillard CC BY-SA 3.0 · Source

A 3-year-old boy presents with intermittent abdominal pain, vomiting, and bloody stools. An ultrasound is performed, the image is shown. What is the MOST appropriate next step in the management of this patient?

A. Stool culture
B. Surgical resection
C. Observation and analgesia
D. Air enema
E. Appendectomy
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 3-year-old child is brought to the GP by their parents who are worried about the appearance of their child's abdomen, as shown in the image. The child is otherwise well, active, and has no pain, vomiting, or changes in bowel habits. On examination, the finding is soft and easily reducible. Vital signs are normal. Based on this presentation and the image, what is the most appropriate initial management?

A. Application of a binder or tape over the area.
B. Advise strict bed rest to prevent worsening.
C. Request an abdominal ultrasound to assess contents.
D. Reassurance and observation for spontaneous closure.
E. Urgent surgical referral for repair.
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A 10-year-old boy presents to his GP with a chronic, intensely itchy rash affecting the flexural areas of his elbows and knees, as well as his neck. His parents report that he has had this condition on and off since infancy, with periods of remission and exacerbation. He also has a history of allergic rhinitis and asthma. On examination, the skin in the affected areas is dry, lichenified, and excoriated. There are also scattered papules and plaques. The patient reports significant sleep disturbance due to the itch. Topical corticosteroids have provided temporary relief in the past, but the rash flares up again soon after stopping treatment. Which of the following is the MOST appropriate next step in managing this patient's atopic dermatitis?

A. Refer the patient to a dermatologist for systemic immunosuppressant therapy without attempting further topical treatments.
B. Initiate treatment with a topical calcineurin inhibitor such as tacrolimus or pimecrolimus.
C. Recommend oral antihistamines as the sole treatment for the itch.
D. Advise strict avoidance of all potential allergens based on unproven allergy testing.
E. Prescribe a potent topical corticosteroid for long-term daily use.
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A 10-year-old presents with a sore throat, fever, and fatigue for 2 days. Examination reveals tonsillar exudates and tender anterior cervical lymph nodes. What is the most appropriate next step in management?

A. Advise symptomatic treatment with paracetamol
B. Refer to an ENT specialist
C. Perform a rapid strep test
D. Order a throat culture
E. Prescribe oral amoxicillin
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An ultrasound showing target sign which is a characteristic finding for intussusception on ultrasound, this ultrasound is for a 3 year old boy with intestinal intussusception.
Image by Frank Gaillard CC BY-SA 3.0 · Source

A 3-year-old boy presents with intermittent abdominal pain, vomiting, and currant jelly stools. An ultrasound is performed, revealing the finding shown. What is the MOST appropriate next step in the management of this patient?

A. Appendectomy
B. Exploratory laparotomy
C. Air enema
D. Stool culture
E. Observation and intravenous fluids
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Pyloric stenosis as seen on ultrasound in a 6 week old
Image by Dr Laughlin Dawes CC BY-SA 4.0 · Source

A 6-week-old male presents with projectile vomiting after feeds. He is otherwise well-appearing, with normal vital signs and no abdominal distension. An ultrasound was performed, and an image is shown. What is the MOST appropriate next step in management?

A. Barium swallow study
B. Upper endoscopy with biopsy
C. Surgical consultation for pyloromyotomy
D. Initiate erythromycin therapy
E. Trial of thickened feeds
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Hypertrophic pyloric stenosis
Image by Adityagupta95 CC0 1.0 · Source

A 3-week-old male infant is brought to the emergency department by his parents due to persistent, non-bilious vomiting after each feeding for the past week. The vomiting has become increasingly forceful. The infant appears mildly dehydrated, and his weight has remained stable since birth. On examination, an olive-shaped mass is palpated in the epigastric region when the infant is not actively vomiting. An upper GI series is performed, and the image is shown. What is the most appropriate next step in the management of this patient?

A. Initiate a trial of thickened feeds
B. Surgical pyloromyotomy
C. Administer intravenous ondansetron and observe
D. Start erythromycin to stimulate gastric emptying
E. Perform an upper endoscopy with biopsy
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 3-year-old child is presented to the general practitioner by their parents who are concerned about the appearance of their child's umbilicus, as depicted in the accompanying image. The child is reported to be entirely asymptomatic, feeding and playing normally, with no history of pain, discomfort, or vomiting. Physical examination reveals normal vital signs and a soft, non-tender abdomen with no signs of obstruction. Considering the clinical presentation and the finding shown, what is the most appropriate initial management plan for this child?

A. Order an abdominal ultrasound scan to evaluate the contents and size of the defect.
B. Arrange an urgent consultation with a paediatric surgeon for immediate operative repair.
C. Prescribe a course of simple analgesia and schedule a routine follow-up appointment in one week.
D. Recommend the application of a firm abdominal binder or tape over the affected area to prevent enlargement.
E. Provide reassurance to the parents regarding the benign nature and likelihood of spontaneous resolution, advising them on signs requiring further assessment.
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Pyloric stenosis as seen on ultrasound in a 6 week old
Image by Dr Laughlin Dawes CC BY-SA 4.0 · Source

A 6-week-old presents with projectile vomiting after feeds. An ultrasound is performed (shown). What is the MOST appropriate next step in management?

A. Trial of thickened feeds
B. Upper endoscopy with biopsy
C. Reassurance and close follow-up
D. Start erythromycin
E. Surgical consultation for pyloromyotomy
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A 10-year-old presents with a sore throat, fever, and tonsillar exudates. Rapid strep test is negative. What is the MOST appropriate next step?

A. Throat culture
B. Azithromycin
C. Observe and provide symptomatic treatment
D. Monospot test
E. Amoxicillin
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A 3-year-old child presents to the clinic with a history of recurrent wheezing episodes, especially during viral infections. What is the most common cause of wheezing in children under 5 years of age?

A. Asthma
B. Foreign body aspiration
C. Viral bronchiolitis
D. Congenital heart disease
E. Cystic fibrosis
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Hypertrophic pyloric stenosis
Image by Adityagupta95 CC0 1.0 · Source

A 3-week-old male infant is brought to the emergency department by his parents due to persistent, non-bilious vomiting after each feeding for the past week. The vomiting has become increasingly forceful. The infant appears mildly dehydrated, with slightly decreased skin turgor. His weight is below the 5th percentile for his age. An abdominal X-ray is unremarkable. Given the clinical presentation, the physician orders further imaging, the results of which are shown. What is the MOST appropriate next step in the management of this patient?

A. Perform an upper endoscopy with biopsy
B. Initiate a trial of thickened feeds
C. Start oral erythromycin
D. Surgical pyloromyotomy
E. Administer intravenous antibiotics
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 4-month-old presents for a well-child visit. The infant is thriving, feeding well, and has no vomiting or respiratory distress. Examination reveals the finding shown. The mass is soft and easily reducible. What is the most appropriate management?

A. Genetic testing for connective tissue disorders
B. Initiation of high-fiber diet
C. Application of an abdominal binder
D. Immediate surgical referral
E. Reassurance and observation
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Hypertrophic pyloric stenosis
Image by Adityagupta95 CC0 1.0 · Source

A 3-week-old male presents with projectile vomiting after feeds. An upper GI series is performed (image shown). What is the MOST appropriate next step in management?

A. Barium swallow study
B. Surgical pyloromyotomy
C. Medical management with erythromycin
D. Trial of thickened feeds
E. Upper endoscopy with biopsy
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A 2-week-old baby is brought to the clinic with abdominal distension and bilious vomiting. On examination, the abdomen is tense and tender. What is the most likely diagnosis?

A. Hypertrophic pyloric stenosis
B. Necrotizing enterocolitis
C. Hirschsprung disease
D. Meconium ileus
E. Intestinal atresia
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Hypertrophic pyloric stenosis
Image by Adityagupta95 CC0 1.0 · Source

A 3-week-old male presents with projectile vomiting. Upper GI series (image shown). What electrolyte abnormality is MOST likely?

A. Hypochloremic metabolic alkalosis
B. Hyperkalemia
C. Hypophosphatemia
D. Hyperchloremic metabolic acidosis
E. Hyponatremia
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Neuroblastoma, CT of the abdomen
Image by RadsWiki CC BY-SA 3.0 · Source

A 4-year-old with abdominal pain and hypertension has this CT. What is the MOST appropriate next step in management?

A. Surgical resection
B. Observation with serial imaging
C. Alpha-blockade
D. Radiation therapy
E. Chemotherapy
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Neuroblastoma, CT of the abdomen
Image by RadsWiki CC BY-SA 3.0 · Source

A 4-year-old child is brought to the emergency department with a 3-week history of increasing abdominal distension, intermittent pain, and decreased activity. Parents also report occasional flushing episodes and unexplained fevers. On examination, a large, firm, irregular mass is palpable in the upper abdomen, extending across the midline. Vital signs are stable, and routine blood tests, including full blood count, electrolytes, and liver function tests, are within normal limits. An abdominal CT scan is performed (image provided). Based on the findings demonstrated in the image and the clinical presentation, which of the following investigations is most critical for accurate staging and risk stratification in this likely diagnosis?

A. Serum alpha-fetoprotein and beta-human chorionic gonadotropin levels
B. Upper gastrointestinal series with small bowel follow-through
C. Iodine-123 metaiodobenzylguanidine (MIBG) scan
D. Renal biopsy
E. Colonoscopy
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A 6-month-old baby has abdominal swelling and vomiting. An abdominal X-ray shows a 'double bubble' sign. What is the most likely diagnosis?

A. Pyloric stenosis
B. Duodenal atresia
C. Meconium ileus
D. Intussusception
E. Malrotation with volvulus.
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A neonate, born at 38 weeks gestation, presents with bilious vomiting starting 12 hours after birth. Antenatal ultrasound revealed polyhydramnios. On examination, the baby is active and has a distended upper abdomen but a scaphoid lower abdomen. An abdominal X-ray shows a 'double bubble' sign. Which of the following is the most appropriate next step in the management of this neonate, considering potential associated complications?

A. Immediately perform a contrast enema to rule out meconium ileus as a cause of the obstruction.
B. Initiate intravenous fluids, nasogastric decompression, and prepare for surgical intervention after stabilization.
C. Begin feeds with a hydrolysed formula to assess tolerance and rule out milk protein allergy.
D. Start the neonate on broad-spectrum antibiotics to cover potential bacterial translocation.
E. Perform an upper gastrointestinal endoscopy to visualize the obstruction and obtain biopsies.
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 6-month-old male infant is brought to the emergency department by his parents. They report that they have noticed a bulge on his abdomen that seems to get larger when he cries. The infant is otherwise healthy, feeding well, and has normal bowel movements. On examination, the infant is afebrile, and his vital signs are within normal limits. The abdomen is soft and non-tender. Palpation reveals a soft, reducible mass at the umbilicus, as shown in the image. What is the MOST appropriate next step in the management of this patient?

A. Urgent ultrasound to rule out incarceration
B. Application of an abdominal binder
C. Reassurance and observation
D. Immediate surgical referral for elective repair
E. Initiation of a high-fiber diet to prevent constipation
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An ultrasound showing target sign which is a characteristic finding for intussusception on ultrasound, this ultrasound is for a 3 year old boy with intestinal intussusception.
Image by Frank Gaillard CC BY-SA 3.0 · Source

A 3-year-old boy presents with a 12-hour history of intermittent, severe abdominal pain, drawing his legs up to his chest. He has vomited several times. His vital signs are stable: HR 110, BP 95/60, RR 24, Temp 37.2°C. On examination, he is irritable but comfortable between episodes of pain. His abdomen is soft but mildly distended. A focused abdominal ultrasound is performed, yielding the image provided. Based on the clinical presentation and the findings shown, which of the following non-surgical interventions is typically attempted first to resolve the underlying issue?

A. Nasogastric tube insertion for decompression and bowel rest
B. Pneumatic reduction under fluoroscopic guidance
C. Administration of intravenous opioids for pain control followed by observation
D. Intravenous fluid resuscitation and broad-spectrum antibiotics
E. Urgent surgical exploration and manual reduction
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Neuroblastoma, CT of the abdomen
Image by RadsWiki CC BY-SA 3.0 · Source

A 4-year-old presents with abdominal distension, pain, and weight loss over several weeks. On examination, a firm, irregular abdominal mass is palpable. Blood tests show mild anaemia. The provided image is an axial CT slice of the abdomen. Considering the clinical presentation and the findings demonstrated in the image, which of the following investigations is the MOST appropriate initial step to establish a definitive diagnosis?

A. Image-guided biopsy of the abdominal mass.
B. Whole-body 123I-MIBG scintigraphy.
C. Measurement of urinary catecholamine metabolites.
D. Bone marrow aspirate and trephine biopsy.
E. Laparoscopic exploration and mass excision.
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Pyloric stenosis as seen on ultrasound in a 6 week old
Image by Dr Laughlin Dawes CC BY-SA 4.0 · Source

A 5-week-old male infant presents to the emergency department with a 3-day history of non-bilious, projectile vomiting after each feed. He is otherwise well-appearing and afebrile. His mother reports that he is feeding well but seems increasingly hungry after vomiting. On examination, the infant is alert and active, with slightly dry mucous membranes. Abdominal examination is unremarkable, with no palpable masses. An ultrasound of the abdomen is performed, the image of which is shown. What is the most appropriate next step in the management of this patient?

A. Surgical consultation for pyloromyotomy
B. Administer intravenous ondansetron and observe
C. Upper gastrointestinal endoscopy with biopsy
D. Discharge home with instructions for frequent small-volume feeds
E. Initiate a trial of thickened feeds
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An ultrasound showing target sign which is a characteristic finding for intussusception on ultrasound, this ultrasound is for a 3 year old boy with intestinal intussusception.
Image by Frank Gaillard CC BY-SA 3.0 · Source

A 3-year-old boy presents with a 12-hour history of intermittent, severe abdominal pain, non-bilious vomiting, and decreased activity. Parents report redcurrant jelly stool. On exam, a palpable mass is noted. Vitals are stable. An ultrasound is performed (shown above). Considering the clinical picture and the image findings, which non-surgical intervention is indicated?

A. Urgent surgical exploration
B. Barium enema reduction
C. Pneumatic reduction under fluoroscopic guidance
D. Intravenous fluid resuscitation and observation
E. Administration of broad-spectrum antibiotics
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 14-month-old child is presented to the general practitioner by their parents, who are concerned about a noticeable protrusion around the navel. They report this bulge is more prominent when the child cries or strains but easily disappears when the child is relaxed or sleeping. There are no reports of pain, discomfort, changes in bowel habits, or feeding difficulties. The child is meeting all developmental milestones and appears well. On examination, vital signs are stable and within age-appropriate ranges. The abdomen is soft and non-tender, with no distension. The finding illustrated in the accompanying image is observed. Based on this clinical presentation and examination, what is the most appropriate initial management plan?

A. Refer the child urgently to a paediatric surgeon for immediate assessment and potential repair.
B. Recommend applying a specific binder or tape over the area to facilitate closure.
C. Provide reassurance to the parents regarding the benign nature of the finding and advise observation, explaining the high likelihood of spontaneous resolution by school age.
D. Advise the parents to present immediately to the nearest emergency department if the bulge is visible.
E. Order an abdominal ultrasound to assess the contents and size of the defect.
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A 3-year-old child presents to the emergency department with a sudden onset of cough, wheezing, and difficulty breathing after playing with small toys. The child is in mild respiratory distress, with a respiratory rate of 40 breaths per minute and oxygen saturation of 92% on room air. On auscultation, there are decreased breath sounds on the right side with wheezing. The child has no fever, and there is no history of recent illness. What is the most likely cause of these symptoms?

A. Foreign body aspiration
B. Bacterial pneumonia
C. Viral bronchiolitis
D. Asthma exacerbation
E. Allergic reaction
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A 5-year-old child with a known history of asthma presents with acute shortness of breath and wheezing after playing outside. What is the most appropriate initial treatment?

A. Administer intravenous magnesium sulfate
B. Administer salbutamol via a spacer
C. Administer ipratropium bromide
D. Administer oral prednisone
E. Start oxygen therapy
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An ultrasound showing target sign which is a characteristic finding for intussusception on ultrasound, this ultrasound is for a 3 year old boy with intestinal intussusception.
Image by Frank Gaillard CC BY-SA 3.0 · Source

A 2-year-old boy presents with abdominal pain and vomiting. An ultrasound is performed, as shown. What is the MOST likely lead point for this condition?

A. Ileocolic junction
B. Polyp
C. Appendix
D. Meckel's diverticulum
E. Duodenal duplication cyst
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 1-year-old child presents to the GP with parental concern about a bulge on the abdomen, as shown in the image. The child is asymptomatic, feeding well, and has normal bowel movements. Examination reveals a soft, reducible finding at the umbilicus; the abdomen is non-tender with normal bowel sounds. Based on this presentation and the image, what is the most appropriate initial management?

A. Arrange an urgent abdominal ultrasound.
B. Recommend applying a binder or tape over the area.
C. Prescribe analgesia for potential pain.
D. Reassure parents about likely spontaneous resolution and schedule routine follow-up.
E. Refer urgently to paediatric surgery for repair.
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A 10-year-old boy with a history of asthma presents to the emergency department with wheezing and shortness of breath. His mother reports that he has been using his salbutamol inhaler more frequently over the past two days. On examination, he has a respiratory rate of 28 breaths per minute, and his oxygen saturation is 92% on room air. What is the most appropriate initial management step?

A. Administer nebulized salbutamol
B. Administer intravenous magnesium sulfate
C. Provide supplemental oxygen
D. Increase the dose of inhaled corticosteroids
E. Start oral corticosteroids
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Neuroblastoma, CT of the abdomen
Image by RadsWiki CC BY-SA 3.0 · Source

A 3-year-old presents with abdominal distension and vague pain. Vitals are stable. An abdominal CT is performed (image attached). Elevated levels of HVA and VMA are noted in the urine. What is the MOST likely origin of the primary lesion?

A. Spleen
B. Pancreas
C. Liver
D. Adrenal gland
E. Kidney
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Pyloric stenosis as seen on ultrasound in a 6 week old
Image by Dr Laughlin Dawes CC BY-SA 4.0 · Source

A 6-week-old male infant presents with a 1-week history of progressively worsening non-bilious vomiting, often projectile, occurring shortly after feeds. His parents report he is constantly hungry and irritable but has had poor weight gain. On examination, he is alert but appears thin. Vital signs are stable. Abdominal examination is soft, non-tender, with no palpable mass. An abdominal ultrasound is performed, the image of which is shown. Considering the clinical presentation and the findings depicted, what is the most appropriate initial management strategy?

A. Referral to a paediatric gastroenterologist for further investigation
B. Discharge home with advice on smaller, more frequent feeds
C. Urgent upper gastrointestinal contrast study
D. Surgical pyloromyotomy after fluid and electrolyte correction
E. Trial of antiemetic medication and thickened feeds
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A 10-year-old boy with a known history of asthma presents to the emergency department. He developed symptoms three days after a viral upper respiratory tract infection. On examination, he is tachypnoeic (respiratory rate 48 breaths/min), tachycardic (heart rate 130 bpm), and hypoxic with an oxygen saturation of 91% on room air. He is speaking only in short phrases but remains alert and is afebrile. Auscultation reveals a widespread wheeze throughout his chest. A COVID swab performed yesterday was negative. Which investigation is the most appropriate next step in the immediate management of this patient?

A. Full Blood Count (FBC)
B. No further diagnostics are required immediately.
C. Chest X-ray
D. Peak Expiratory Flow (PEF) measurement
E. Arterial Blood Gas (ABG)
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 6-month-old presents for a well-child check. The image shows the abdominal exam. Parents report it enlarges when crying. What is the most appropriate next step?

A. Immediate surgical exploration
B. Reassurance and observation
C. Initiation of diuretic therapy
D. Application of an abdominal binder
E. Surgical referral for elective repair
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 6-month-old infant presents for a routine check-up. The mother reports the infant is feeding well and has normal bowel movements. On examination, you observe the finding in the image. The mass is soft and easily reducible. What is the MOST appropriate next step in management?

A. Initiation of high-fiber diet
B. Application of an abdominal binder
C. Immediate surgical referral
D. Genetic testing for connective tissue disorders
E. Reassurance and observation
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A 6-year-old boy is brought to the emergency department by his parents due to sudden onset wheezing and difficulty breathing. He has a history of atopic dermatitis and allergic rhinitis. His parents mention that he was playing outside when the symptoms began. On examination, he is in mild respiratory distress with a respiratory rate of 28 breaths per minute, oxygen saturation of 94% on room air, and bilateral wheezing on auscultation. There is no fever, and his heart rate is 110 bpm. Which of the following is the most likely diagnosis?

A. Asthma exacerbation
B. Bacterial pneumonia
C. Foreign body aspiration
D. Anaphylaxis
E. Viral bronchiolitis
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Neuroblastoma, CT of the abdomen
Image by RadsWiki CC BY-SA 3.0 · Source

A 2-year-old child is evaluated for a 6-week history of increasing abdominal girth, decreased appetite, and occasional bone pain. Physical examination reveals a large, firm, irregular mass in the upper abdomen that appears fixed and crosses the midline. Vital signs are within normal limits for age. Initial investigations show mild anaemia and elevated serum lactate dehydrogenase. An abdominal CT scan is performed (image provided). Given the findings demonstrated in the image and the clinical context, which of the following molecular or genetic analyses is considered a critical determinant of risk stratification and influences treatment intensity for the most likely underlying malignancy?

A. BCR-ABL fusion transcript detection
B. TP53 gene sequencing
C. WT1 gene mutation analysis
D. ALK gene mutation analysis
E. MYCN amplification status
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An ultrasound showing target sign which is a characteristic finding for intussusception on ultrasound, this ultrasound is for a 3 year old boy with intestinal intussusception.
Image by Frank Gaillard CC BY-SA 3.0 · Source

A 3-year-old boy presents with intermittent severe abdominal pain, vomiting, and lethargy. On examination, he is afebrile with a soft but slightly distended abdomen. An ultrasound is performed (image provided). Based on the clinical presentation and the image findings, what is the most appropriate next step in the management of this patient?

A. Pneumatic reduction under fluoroscopy
B. Admission for observation and IV fluids
C. Discharge home with pain relief
D. CT abdomen and pelvis
E. Urgent surgical exploration
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Neuroblastoma, CT of the abdomen
Image by RadsWiki CC BY-SA 3.0 · Source

A 3-year-old presents with abdominal distension, irritability, and periorbital ecchymosis. Examination reveals a firm, irregular abdominal mass. The provided image is an axial CT slice. Considering the clinical presentation and the findings demonstrated in the image, which of the following biochemical markers is MOST likely to be significantly elevated?

A. Serum CA-125
B. Urinary metanephrines
C. Urinary vanillylmandelic acid (VMA) and homovanillic acid (HVA)
D. Serum alpha-fetoprotein (AFP)
E. Serum lactate dehydrogenase (LDH)
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A 14-year-old girl who has been living alone presents with a positive urine pregnancy test. She states she was raped 6 months ago and wishes to terminate the pregnancy. What is the next appropriate step?

A. Refer her to a gynecologist.
B. Terminate the pregnancy.
C. Send her to a women's home.
D. Inform the police.
E. Inform child protection services.
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A 10-year-old boy struggles with inattention at school, often daydreaming and losing focus. His grades are declining, and he forgets homework. Parents report similar issues at home. What's the most appropriate initial step?

A. Academic tutoring
B. Trial of stimulant medication
C. Comprehensive ADHD assessment
D. Referral to a child psychologist for behavioural therapy
E. Parenting skills training
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A 1-year-old child is brought to the emergency department with a 3-day history of cough, wheezing, and difficulty breathing. The child has a fever of 38.5°C and a runny nose. On examination, the child appears in mild respiratory distress with nasal flaring and intercostal retractions. Auscultation reveals diffuse wheezing and crackles throughout the lung fields. The child has no significant past medical history and is up to date with vaccinations. A chest X-ray shows hyperinflation but no focal consolidation. Which of the following is the most likely diagnosis?

A. Foreign body aspiration
B. Asthma
C. Croup
D. Bronchiolitis
E. Pneumonia
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A 5-year-old boy is brought to the clinic by his parents due to a 3-day history of fever, irritability, and refusal to eat. On examination, he has a temperature of 39°C, erythematous oropharynx, and tender cervical lymphadenopathy. There are also vesicular lesions on his hands and feet. What is the most likely diagnosis?

A. Varicella (chickenpox)
B. Scarlet fever
C. Hand, foot, and mouth disease
D. Kawasaki disease
E. Herpangina
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An ultrasound showing target sign which is a characteristic finding for intussusception on ultrasound, this ultrasound is for a 3 year old boy with intestinal intussusception.
Image by Frank Gaillard CC BY-SA 3.0 · Source

A 3-year-old boy presents with sudden onset, intermittent, severe abdominal pain, vomiting, and lethargy. Examination reveals a pale child with a soft abdomen. Vitals are stable. An abdominal ultrasound is performed (image provided). What is the most appropriate next step in management?

A. Admission for observation and serial abdominal exams
B. Intravenous antibiotics and fluid resuscitation
C. CT abdomen/pelvis with contrast
D. Pneumatic reduction under fluoroscopy
E. Urgent surgical exploration
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