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confusion

Practice targeted AMC-style multiple-choice questions on confusion.

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A 72-year-old woman is admitted to the hospital with increasing confusion and generalized weakness over the past week. Her medical history includes hypertension, for which she takes hydrochlorothiazide 25mg daily. On examination, she is lethargic and disoriented. Her blood pressure is 110/70 mmHg, heart rate is 88 bpm, and respiratory rate is 16 breaths per minute. Neurological examination reveals decreased reflexes. Initial laboratory investigations reveal the following: Sodium: 118 mmol/L Potassium: 3.8 mmol/L Chloride: 85 mmol/L Bicarbonate: 24 mmol/L Blood Urea Nitrogen (BUN): 25 mg/dL Creatinine: 1.1 mg/dL Glucose: 95 mg/dL Urine osmolality is 600 mOsm/kg. Serum osmolality is 250 mOsm/kg. Which of the following is the most appropriate initial management strategy?

A. Initiation of desmopressin (DDAVP) therapy to reduce free water excretion.
B. Administration of intravenous hypertonic saline (3% NaCl) at a rate of 50 mL/hour.
C. Administration of a loop diuretic (e.g., furosemide) to promote free water excretion.
D. Administration of intravenous normal saline (0.9% NaCl) at a rate of 100 mL/hour.
E. Fluid restriction to 800-1000 mL/day and monitoring of serum sodium levels every 4-6 hours.
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An 85-year-old man from a nursing home presents with new confusion, mild cough, and temperature 37.9°C. Chest X-ray shows a right lower lobe infiltrate. He has dysphagia. Considering his presentation and risk factors, which initial antibiotic regimen is most appropriate?

A. Ceftriaxone
B. Azithromycin
C. Amoxicillin-clavulanate
D. Doxycycline
E. Amoxicillin
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An old man presents with 6 months of memory decline, falls, visual hallucinations, agitation, and confusion. Which of the following features is relevant to diagnosing his condition?

A. Parkinsonian features
B. Normal CSF markers for amyloid and tau.
C. Cerebellar signs
D. Significant early memory impairment.
E. Absence of motor symptoms.
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An 80-year-old woman is brought to the emergency department from a nursing home due to increased lethargy and confusion over the past 24 hours. Her history includes dementia, hypertension, and type 2 diabetes. Nursing staff report poor oral intake for 48 hours and a recent cough. On examination, she is drowsy but rousable. Her vital signs are: BP 85/50 mmHg, HR 110 bpm, RR 22 breaths/min, Temp 37.8°C, SpO2 94% on air. Capillary refill time is 4 seconds. Chest auscultation reveals decreased breath sounds at the bases. Abdomen is soft. Urine dipstick shows leukocytes and nitrites. She is on lisinopril and metformin. What is the most appropriate initial management step?

A. Administer intravenous fluid bolus (e.g., 500 mL crystalloid)
B. Administer oral rehydration solution
C. Obtain a chest X-ray and urine culture
D. Discontinue lisinopril and monitor blood pressure
E. Administer broad-spectrum intravenous antibiotics
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An 18-year-old teenage girl presents with a sudden change in behavior at a music festival, appearing confused and aggressive after consuming 5-6 vodkas, with uncertainty about illicit drug use. What is the most appropriate next step in her management in the Australian context?

A. Administer IV fluids to sober her up.
B. Leave the patient alone to cool off.
C. Calmly de-escalate in a quiet room and assess for underlying causes.
D. Restrain the patient physically until she calms down.
E. Immediately administer IV droperidol 10 mg.
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Post-embolization arteriogram showing coiled aneurysm (indicated by yellow arrows) of the posteriorcerebral artery with a residual aneurysmal sac.
Image by Promod Pillai, Aftab Karim, Anil Nanda CC BY 2.0 · Source

A 68-year-old woman with a history of hypertension presents with a severe headache and altered mental status. Aneurysmal coiling was performed. The image shows a post-operative angiogram. 6 hours later, she develops a fever of 38.5°C and worsening confusion. What is the MOST appropriate next step?

A. Obtain blood cultures and start broad-spectrum antibiotics
B. Increase the dose of her antihypertensive medication
C. Repeat CT angiogram of the head
D. Initiate nimodipine
E. Administer intravenous mannitol
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A 62-year-old man presents to the emergency department with sudden onset of severe headache, nausea, and vomiting. He has a history of poorly controlled hypertension and is currently on no medications. On examination, he is drowsy but arousable, with a blood pressure of 210/120 mmHg and a heart rate of 90 bpm. Neurological examination reveals right-sided hemiparesis and a left gaze preference. A CT scan of the head shows a large hyperdense area in the left basal ganglia with surrounding edema. What is the most appropriate initial management for this patient?

A. Immediate surgical evacuation of the hematoma
B. Intravenous labetalol to lower blood pressure
C. Oral antihypertensive therapy to gradually lower blood pressure
D. Intravenous mannitol to reduce intracranial pressure
E. Intravenous thrombolysis to dissolve the clot
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A 68-year-old woman is admitted to the hospital with confusion and muscle weakness. Her medications include hydrochlorothiazide for hypertension. Initial laboratory results show: Sodium 120 mmol/L (Normal: 135-145 mmol/L), Potassium 3.8 mmol/L (Normal: 3.5-5.0 mmol/L), Chloride 90 mmol/L (Normal: 95-105 mmol/L). What is the most likely cause of her hyponatremia?

A. Hyperglycemia
B. Thiazide-induced SIADH
C. Primary polydipsia
D. Renal failure
E. Adrenal insufficiency
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A 78M presents with cough, fever, confusion. BP 90/60, RR 30, Temp 38.5, SpO2 90% on air. CXR shows LUL consolidation. What is the most appropriate initial management?

A. Arrange urgent viral PCR testing
B. Initiate oral antibiotics and admit to general ward
C. Discharge home with oral antibiotics
D. Perform urgent bronchoscopy
E. Initiate IV antibiotics and assess for ICU admission
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An 80-year-old presents with cough, fever, and new confusion. CXR shows right lower lobe consolidation. What is the most appropriate initial antibiotic regimen?

A. Piperacillin-tazobactam
B. Amoxicillin
C. Doxycycline
D. Ciprofloxacin
E. Ceftriaxone and Azithromycin
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An 82-year-old woman from an aged care facility presents with a 2-day history of increased confusion and lethargy. Her baseline is independent living with mild cognitive impairment. She has a chronic cough but no recent change in sputum. Vital signs: T 37.8°C, HR 95 bpm, BP 110/70 mmHg, RR 22 breaths/min, SpO2 92% on room air. Chest examination reveals decreased breath sounds at the right base. Given the clinical presentation and setting, which of the following is the most appropriate initial management step while awaiting the chest X-ray result?

A. Perform a CT scan of the chest to confirm the diagnosis.
B. Administer empiric broad-spectrum antibiotics covering typical and atypical pathogens.
C. Transfer to a tertiary hospital for specialist respiratory review.
D. Administer supplemental oxygen and monitor vital signs closely.
E. Obtain sputum culture and sensitivity before initiating antibiotics.
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An 82-year-old woman with dementia and COPD presents with increased confusion and mild cough. Temperature 37.8°C, HR 95, RR 24, BP 110/70, SpO2 90% on air. Chest sounds are diminished bilaterally. What is the most appropriate initial investigation?

A. Serum procalcitonin
B. Bronchoscopy
C. High-resolution CT chest
D. Chest X-ray
E. Sputum Gram stain and culture
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A 62-year-old woman presents to the emergency department with confusion and lethargy. Her family reports she has been increasingly forgetful over the past week and has had a decreased appetite. She has a history of type 2 diabetes mellitus and hypertension, for which she takes metformin and lisinopril. On examination, she is disoriented to time and place, with dry mucous membranes and decreased skin turgor. Her blood pressure is 100/60 mmHg, heart rate is 110 bpm, and temperature is 37.2°C. Laboratory tests reveal a serum sodium level of 118 mmol/L, serum osmolality of 260 mOsm/kg, and urine osmolality of 500 mOsm/kg. Which of the following is the most appropriate initial management for this patient?

A. Furosemide administration
B. Normal saline infusion
C. Hypertonic saline infusion
D. Fluid restriction
E. Demeclocycline administration
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An 82-year-old man is brought from an aged care facility with a 2-day history of increased confusion and a new cough. He has a history of dementia and hypertension. On examination, his temperature is 38.1°C, pulse 98 bpm, BP 130/80 mmHg, and oxygen saturation 92% on room air. Chest auscultation reveals crackles in the right lower lung field. What is the most appropriate initial investigation?

A. Blood cultures
B. Sputum culture
C. ECG
D. Chest X-ray
E. CT scan of the head
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An 80-year-old presents with cough, fever, and new confusion. Vital signs: T 38.5°C, HR 110, BP 100/60, RR 28, SpO2 90% on air. Chest X-ray shows consolidation. What is the most appropriate initial management step?

A. Oral antibiotics and outpatient management
B. Chest CT scan
C. Bronchoscopy
D. Sputum culture and sensitivity testing
E. Intravenous antibiotics and hospital admission
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A 68-year-old man with hypertension presents with sudden onset right-sided weakness and slurred speech. GCS is 13. BP 190/110 mmHg. What is the most critical initial investigation to guide management?

A. CT angiography
B. Lumbar puncture
C. Non-contrast CT head
D. ECG
E. MRI brain
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A 35-year-old man, recently arrived from a country with a high burden of tuberculosis, presents to the emergency department with a 2-week history of worsening headache, low-grade fever, and general malaise. Over the past 48 hours, he has become increasingly drowsy and confused. He denies cough, weight loss, or night sweats. His past medical history is unremarkable, and he is not on any regular medications. On examination, he is febrile (38.5°C), drowsy but rousable, with a Glasgow Coma Scale (GCS) of 13/15 (E3 V4 M6). His neck is stiff, and Kernig's sign is positive. Fundoscopy is normal. Chest auscultation is clear. Neurological examination reveals no focal deficits. Initial blood tests show a mild lymphocytosis, normal electrolytes, and normal renal and liver function. A non-contrast CT scan of the brain shows subtle basal meningeal enhancement. A lumbar puncture is performed. CSF Results: * Appearance: Slightly turbid * Opening pressure: 25 cm H2O (elevated) * White cell count: 150 cells/µL (normal <5), 80% lymphocytes * Red cell count: 5 cells/µL * Protein: 1.5 g/L (normal 0.15-0.45) * Glucose: 1.8 mmol/L (normal 2.5-4.5), simultaneous blood glucose 5.5 mmol/L Given the clinical presentation and investigation findings, what is the most appropriate immediate next step in management?

A. Start empirical broad-spectrum antibiotics (e.g., ceftriaxone and vancomycin).
B. Wait for the results of CSF Gram stain, bacterial culture, and mycobacterial culture before initiating specific therapy.
C. Perform an urgent MRI of the brain to better delineate meningeal involvement.
D. Administer intravenous acyclovir for possible viral encephalitis/meningitis.
E. Initiate empirical anti-tuberculosis therapy including rifampicin, isoniazid, pyrazinamide, and ethambutol, along with adjunctive corticosteroids.
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An elderly man presents with a 6-month history of memory decline, recurrent falls, visual hallucinations, agitation, and confusion. His wife reports he talks to people who are not visible. Which of the following clinical features is most helpful in diagnosing his condition?

A. Nystagmus
B. Parkinsonian gait/tremor
C. Ataxia
D. Aphasia
E. Hemiparesis
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A 72-year-old man presents to the emergency department with confusion and difficulty walking. His family reports that he has been increasingly forgetful over the past few months and has had several falls. He has a history of hypertension and hyperlipidemia, for which he takes lisinopril and atorvastatin. On examination, he is disoriented to time and place, with a blood pressure of 140/85 mmHg, heart rate of 78 bpm, and a wide-based gait. Neurological examination reveals brisk reflexes and a positive Romberg sign. A CT scan of the head shows mild cortical atrophy but no acute lesions. Which of the following is the most likely diagnosis?

A. Vascular dementia
B. Normal pressure hydrocephalus
C. Parkinson's disease
D. Alzheimer's disease
E. Subdural hematoma
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A 72-year-old woman is admitted to the hospital with increasing confusion and generalized weakness over the past week. Her medical history includes hypertension, for which she takes hydrochlorothiazide 25mg daily. On examination, she is lethargic but arousable. Her blood pressure is 110/70 mmHg, heart rate is 88 bpm, and respiratory rate is 16 breaths per minute. Neurological examination reveals decreased reflexes. Initial laboratory investigations reveal the following: Sodium 118 mmol/L, Potassium 3.8 mmol/L, Chloride 85 mmol/L, Bicarbonate 24 mmol/L, BUN 15 mg/dL, Creatinine 0.8 mg/dL, Glucose 90 mg/dL. Urine osmolality is 600 mOsm/kg. Serum osmolality is 250 mOsm/kg. Which of the following is the most appropriate initial management strategy?

A. Fluid restriction and monitoring of sodium levels
B. Administration of desmopressin (DDAVP)
C. Administration of intravenous normal saline at a rapid infusion rate
D. Administration of a loop diuretic such as furosemide
E. Administration of intravenous 3% hypertonic saline at a rate of 50 mL/hour
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An 82-year-old man with a history of stroke presents with new onset confusion, a mild cough, and a temperature of 37.8°C. A chest X-ray reveals a right lower lobe infiltrate. Which of the following is the most appropriate initial management step?

A. Initiate empiric broad-spectrum antibiotics
B. Order urgent sputum culture
C. Administer IV fluids and monitor
D. Discharge home with oral paracetamol
E. Arrange urgent physiotherapy review
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A 62-year-old woman with a 15-year history of type 2 diabetes mellitus presents to the emergency department with confusion, polyuria, and polydipsia over the past three days. She has been non-compliant with her medications and diet. On examination, she is lethargic and dehydrated, with a blood pressure of 100/60 mmHg, heart rate of 110 bpm, and respiratory rate of 20 breaths per minute. Laboratory tests reveal a blood glucose level of 38 mmol/L, serum sodium of 150 mmol/L, serum potassium of 4.0 mmol/L, serum bicarbonate of 22 mmol/L, and a serum osmolality of 340 mOsm/kg. Urinalysis shows no ketones. Which of the following is the most appropriate initial management step?

A. Intravenous potassium supplementation
B. Intravenous normal saline
C. Oral hypoglycemic agents
D. Intravenous sodium bicarbonate
E. Intravenous insulin infusion
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An 80-year-old man presents with new confusion, cough, and fever. He has a history of COPD. On exam, he is tachypnoeic and has crackles at the right base. His oxygen saturation is 88% on room air. What is the most appropriate initial investigation?

A. Bronchoscopy
B. C-reactive protein
C. Sputum Gram stain and culture
D. High-resolution CT chest
E. Chest X-ray
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An 98-year-old lady with cognitive impairment has had 2 episodes of acute delirium, is pacing, and is vomiting blood. What is the immediate management?

A. Give oral antiemetics and observe.
B. Start IV fluids and wait for review by GP.
C. Call 000 and transfer to the regional hospital.
D. SC line and administer haloperidol, morphine, and midazolam.
E. Arrange an urgent gastroscopy for tomorrow.
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A 25-year-old woman presents to the clinic with a 2-week history of fatigue, sore throat, and swollen glands. She also reports a low-grade fever and mild headache. On examination, she has cervical lymphadenopathy and mild splenomegaly. A monospot test is positive. What is the most appropriate advice regarding her physical activity?

A. Engage in light exercise to improve symptoms
B. Resume normal activities immediately
C. Start a course of corticosteroids to reduce symptoms
D. Avoid all physical activity for 6 months
E. Avoid contact sports for at least 4 weeks
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An 82-year-old man with a history of COPD and mild dementia is brought to the emergency department by his family due to increased confusion over 24 hours. He has had a low-grade fever (37.8°C) and a mild cough for 3 days. On examination, he is drowsy but rousable. His oxygen saturation is 90% on room air. Chest auscultation reveals decreased breath sounds at the bases. A chest X-ray shows bilateral lower lobe infiltrates. His CURB-65 score is 3. Considering the patient's presentation and CURB-65 score, what is the most appropriate initial management plan?

A. Admission to hospital for observation and oral antibiotics.
B. Discharge home with supportive care and review in 24 hours.
C. Admission to ICU for mechanical ventilation and broad-spectrum antibiotics.
D. Outpatient management with oral antibiotics and close follow-up.
E. Admission to hospital with intravenous antibiotics.
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A 62-year-old woman presents to the emergency department with acute confusion and weakness on the right side of her body. She has a history of atrial fibrillation and is on warfarin for anticoagulation. Her INR is 3.5. On examination, she is disoriented to time and place, with a right-sided facial droop and hemiparesis. A CT scan of the head shows a left-sided intracerebral hemorrhage. What is the most appropriate next step in the management of this patient?

A. Start intravenous heparin
B. Administer intravenous vitamin K and prothrombin complex concentrate
C. Initiate oral antihypertensive therapy
D. Administer intravenous mannitol
E. Perform an urgent neurosurgical intervention
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An 80-year-old with COPD presents with fever, cough, and increased sputum. CXR shows consolidation. BP 85/50, HR 110, RR 28, SpO2 88% on air. Confused. What is the most appropriate initial management step?

A. Initiate high-flow oxygen therapy
B. Administer intravenous fluids and broad-spectrum antibiotics
C. Prescribe oral amoxicillin
D. Obtain blood cultures and sputum for microscopy/culture
E. Assess for immediate intubation and ventilation
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