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cough

Practice targeted AMC-style multiple-choice questions on cough.

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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 28-year-old female presents with a chronic cough and fatigue. She has no significant past medical history but reports recent travel to Southeast Asia. A chest PET-CT was performed. What is the MOST appropriate next step in the management of this patient?

A. Order a bronchoscopy with biopsy
B. Start a trial of inhaled corticosteroids
C. Repeat the PET-CT scan in 3 months
D. Initiate anti-tuberculosis therapy
E. Prescribe a course of broad-spectrum antibiotics
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A 65-year-old man with hypertension is started on a medication that blocks the angiotensin-converting enzyme (ACE). What is the most common side effect of this class of drugs?

A. Hyperkalemia
B. Acute kidney injury
C. Angioedema
D. Hypotension
E. Dry cough
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 45-year-old male presents with a 3-month history of cough and unintentional weight loss. He is a former smoker. Physical examination is unremarkable. A chest X-ray showed a nodule, and a PET-CT was performed for further characterisation, an axial view is shown. Considering the imaging findings and clinical presentation, what is the MOST appropriate next diagnostic step?

A. Initiate empirical anti-tuberculous therapy
B. Repeat sputum studies for acid-fast bacilli
C. Thoracic surgical referral for wedge resection
D. CT-guided percutaneous biopsy
E. Follow-up PET-CT in 3 months
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A 32-year-old woman presents to the clinic with a 2-week history of a persistent cough and shortness of breath. She has no significant past medical history and is a non-smoker. On examination, she has bilateral wheezing and reduced breath sounds. A chest X-ray shows hyperinflation of the lungs. What is the most likely diagnosis?

A. Chronic obstructive pulmonary disease (COPD)
B. Asthma
C. Heart failure
D. Pneumonia
E. Pulmonary embolism
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A 57-year-old lady with a chronic cough, a 35 pack-year smoking history, and breathlessness with daily tasks has had spirometry done. What is the likely interpretation of the spirometry results?

A. Normal spirometry
B. Mod OAD, no reversibility.
C. Severe obstructive airway disease, with reversibility.
D. Restrictive pattern
E. Mild OAD, no reversibility.
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A 72-year-old man presents to the clinic with progressive shortness of breath and a chronic cough producing white sputum. He has a 40-pack-year smoking history and worked in construction for most of his life. On examination, he has clubbing of the fingers and crackles at the lung bases. A chest X-ray shows diffuse reticular opacities, particularly at the lung bases. What is the most likely diagnosis?

A. Idiopathic pulmonary fibrosis
B. Lung cancer
C. Asbestosis
D. Congestive heart failure
E. Chronic obstructive pulmonary disease (COPD)
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A 40-year-old man presents with fever, pleuritic chest pain, and cough. A chest X-ray shows a pleural effusion. What is the next step in management?

A. Start steroids.
B. Perform a thoracentesis.
C. Start antibiotics.
D. Observe and repeat imaging in 2 weeks.
E. Order a CT scan.
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A 30-year-old woman presents to her GP with a 2-week history of a persistent cough, night sweats, and unintentional weight loss. She has recently returned from a trip to Southeast Asia. On examination, she appears thin and has crackles in the upper zones of her lungs. A chest X-ray shows cavitary lesions in the right upper lobe. What is the most likely diagnosis?

A. Chronic obstructive pulmonary disease (COPD)
B. Pulmonary tuberculosis
C. Pneumonia
D. Sarcoidosis
E. Lung cancer
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X-ray of hiatal hernia
Image by Ahmed Farhat, Daryn Towle CC BY 4.0 · Source

A 72-year-old woman presents with a long history of heartburn, regurgitation, and recently developed a chronic cough, particularly at night. Physical examination is unremarkable. A chest radiograph is obtained. Considering the radiographic findings in the context of the patient's presentation, what is the most likely pathophysiological mechanism contributing to her chronic cough?

A. Pulmonary oedema secondary to cardiac dysfunction
B. Interstitial lung disease causing restrictive ventilatory defect
C. Compression of the left main bronchus by an enlarged lymph node
D. Bronchial hyperreactivity triggered by inhaled allergens
E. Chronic aspiration of gastric contents
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A 58-year-old man with a history of hypertension and left ventricular systolic dysfunction (LVSD) is being treated with an ACE inhibitor. His blood pressure is well-controlled, but he develops a persistent, dry cough that is affecting his sleep and quality of life. What is the most appropriate next step in management?

A. Add a cough suppressant
B. Switch to an angiotensin II receptor blocker (ARB)
C. Add a diuretic
D. Discontinue the ACE inhibitor and start a beta-blocker
E. Reduce the dose of the ACE inhibitor
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 30-year-old immigrant presents with chronic cough and night sweats. Sputum is negative for AFB. What is the MOST appropriate next step in management?

A. Prescribe antitussives
B. Repeat sputum AFB
C. Start empiric antibiotics
D. Bronchoscopy with biopsy
E. Initiate isoniazid prophylaxis
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A 70-year-old woman with a history of diabetes presents with fever, cough, and weight loss. A chest X-ray shows a cavitary lesion in the right upper lobe. What is the most likely diagnosis?

A. Sarcoidosis
B. Lung cancer
C. Tuberculosis
D. Lung abscess
E. Pneumocystis pneumonia
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 65-year-old patient with a history of smoking presents with a chronic cough and mild weight loss over three months. Physical examination is unremarkable, and vital signs are stable. Routine blood tests, including full blood count and inflammatory markers, are within normal limits. A chest X-ray revealed a solitary pulmonary nodule in the right upper lobe. Subsequent PET-CT imaging was performed as part of the diagnostic workup. Considering the findings demonstrated in the image provided, which of the following is the most appropriate next step in the management of this patient?

A. Refer for surgical resection
B. Bronchoscopy with biopsy or fine needle aspiration
C. Prescribe a course of inhaled corticosteroids
D. Initiate empirical broad-spectrum antibiotics
E. Repeat PET-CT scan in three months
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A 25-year-old gentleman presents with 3 days of rhinorrhea, fever, cough, and abdominal pain. On examination, his temperature is 39.6°C, he has reduced breath sounds, and an enlarged spleen. Which of the following causative pathogens, if identified, would require mandatory notification in Australia?

A. Respiratory Syncytial Virus (RSV)
B. Mycoplasma pneumoniae
C. Adenovirus
D. Chlamydia psittaci
E. Parainfluenzae
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An 80-year-old presents with cough, fever, and new confusion. CXR shows right lower lobe consolidation. What is the most appropriate initial antibiotic regimen?

A. Piperacillin-tazobactam
B. Amoxicillin
C. Doxycycline
D. Ciprofloxacin
E. Ceftriaxone and Azithromycin
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X-ray of hiatal hernia
Image by Ahmed Farhat, Daryn Towle CC BY 4.0 · Source

A 75-year-old presents with a 4-month history of increasing dysphagia to solids, occasional regurgitation, and chronic cough, particularly at night. He denies significant weight loss or chest pain. Past medical history includes type 2 diabetes and hypertension. Medications are metformin and perindopril. Physical examination is unremarkable. A chest X-ray is performed as part of the initial assessment. Considering the clinical presentation and the radiographic findings, which of the following investigations is most appropriate at this stage?

A. Barium swallow study
B. Oesophageal manometry
C. Oesophago-gastro-duodenoscopy
D. High-resolution CT chest
E. Ambulatory ECG monitoring
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An 82-year-old woman from an aged care facility presents with a 2-day history of increased confusion and lethargy. Her baseline is independent living with mild cognitive impairment. She has a chronic cough but no recent change in sputum. Vital signs: T 37.8°C, HR 95 bpm, BP 110/70 mmHg, RR 22 breaths/min, SpO2 92% on room air. Chest examination reveals decreased breath sounds at the right base. Given the clinical presentation and setting, which of the following is the most appropriate initial management step while awaiting the chest X-ray result?

A. Perform a CT scan of the chest to confirm the diagnosis.
B. Administer empiric broad-spectrum antibiotics covering typical and atypical pathogens.
C. Transfer to a tertiary hospital for specialist respiratory review.
D. Administer supplemental oxygen and monitor vital signs closely.
E. Obtain sputum culture and sensitivity before initiating antibiotics.
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 32-year-old male, recent immigrant from a high-TB prevalence country, presents with a persistent cough and night sweats for the past two months. He denies fever or weight loss. Physical examination is unremarkable except for mild, diffuse rhonchi on auscultation. Sputum cultures are pending. A PET-CT scan of the chest was performed, the axial view is shown. Given the clinical context and imaging findings, what is the MOST appropriate next step in management?

A. Prescribe a course of broad-spectrum antibiotics for presumed bacterial pneumonia
B. Initiate a four-drug anti-tuberculosis regimen
C. Repeat the PET-CT scan in three months to assess for interval growth
D. Start a course of oral corticosteroids to reduce inflammation
E. Order a bronchoscopy with transbronchial biopsy
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 28-year-old female, recently emigrated from Southeast Asia, presents to her general practitioner with complaints of fatigue, a persistent low-grade fever (37.8°C), and a non-productive cough that has been present for approximately one month. She denies any significant past medical history and is not currently taking any medications. Physical examination reveals slightly diminished breath sounds in the upper right lobe, but is otherwise unremarkable. Initial blood work, including a complete blood count and comprehensive metabolic panel, are within normal limits. A chest X-ray revealed a suspicious lesion in the right upper lobe, prompting a PET-CT scan, an axial slice of which is shown. Given the patient's history, clinical presentation, and the findings on the PET-CT scan, which of the following is the MOST appropriate next step in the diagnostic workup?

A. Prescribe a course of broad-spectrum antibiotics to cover community-acquired pneumonia.
B. Order a CT-guided needle biopsy of the lesion.
C. Start empiric treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE).
D. Refer the patient to a pulmonologist for bronchoscopy with bronchoalveolar lavage.
E. Initiate sputum acid-fast bacilli (AFB) smears and cultures.
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A 4-year-old child presents with a history of recurrent wheezing and cough, particularly at night and with exercise. What is the most appropriate long-term management strategy?

A. Antibiotics
B. Short-acting beta-agonists as needed
C. Oral corticosteroids
D. Inhaled corticosteroids
E. Leukotriene receptor antagonists
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Giant hiatal hernia, CT image. 63 year old man.
Image by Jmarchn CC BY 4.0 · Source

A 68-year-old male presents to his general practitioner with a three-month history of progressive dysphagia to both solids and liquids, accompanied by postprandial regurgitation. He also reports experiencing early satiety and occasional episodes of nocturnal coughing. His past medical history is significant for well-controlled hypertension and a remote history of smoking (quit 20 years ago). Physical examination reveals mild epigastric fullness, but is otherwise unremarkable. His vital signs are within normal limits. An abdominal CT scan with contrast was performed, and a representative image is shown. Given the clinical presentation and the findings on the image, which of the following is the MOST appropriate next step in the management of this patient?

A. Referral to a gastroenterologist for surgical evaluation
B. Esophageal manometry to evaluate esophageal motility
C. Empiric treatment with antibiotics for possible aspiration pneumonia
D. Initiation of a proton pump inhibitor and lifestyle modifications
E. Barium swallow study to further delineate the anatomy
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 28-year-old immunocompetent patient presents with a chronic cough and low-grade fever. Initial investigations, including sputum microscopy, are negative. A PET-CT scan was performed (image shown). What is the MOST appropriate next step?

A. Bronchoscopy with biopsy
B. Empiric antibiotic therapy
C. Referral for surgical resection
D. Repeat sputum cultures
E. Initiate anti-tuberculosis therapy
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A 35-year-old man presents to the clinic with a 3-month history of persistent cough, night sweats, and weight loss. He has a history of travel to Southeast Asia six months ago. On examination, he appears thin and has crackles in the upper zones of his lungs. A chest X-ray shows cavitary lesions in the right upper lobe. What is the most likely diagnosis?

A. Sarcoidosis
B. Pneumonia
C. Lung cancer
D. Chronic obstructive pulmonary disease (COPD)
E. Pulmonary tuberculosis
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A 45-year-old woman presents to her general practitioner with a 3-month history of persistent cough and occasional wheezing. She has a history of asthma, which has been well-controlled with inhaled corticosteroids. She denies any recent respiratory infections or changes in her medication. On examination, her vital signs are normal, and there are scattered wheezes on auscultation. Spirometry shows a reduced FEV1/FVC ratio that improves significantly after bronchodilator administration. What is the most appropriate next step in the management of this patient?

A. Increase the dose of inhaled corticosteroids
B. Start oral corticosteroids
C. Refer for allergy testing
D. Add a long-acting beta-agonist (LABA)
E. Prescribe a leukotriene receptor antagonist
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A 45-year-old man presents to the general practice clinic with a 6-month history of progressive shortness of breath and a persistent dry cough. He works as a construction worker and has a 20-pack-year smoking history. On examination, he has clubbing of the fingers and fine inspiratory crackles at the lung bases. Pulmonary function tests show a restrictive pattern. A high-resolution CT scan of the chest reveals reticular opacities and honeycombing predominantly in the lower lobes. Which of the following is the most likely diagnosis?

A. Sarcoidosis
B. Hypersensitivity pneumonitis
C. Idiopathic pulmonary fibrosis
D. Asbestosis
E. Chronic obstructive pulmonary disease
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An 8-year-old girl presents with chronic night cough and wheezing, with possible asthma. What is the minimum age for spirometry?

A. 8 years old
B. 7 years old
C. 5 years old
D. 6 years old
E. 4 years old
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A 2-year-old child is brought to the emergency department by their parents due to a persistent cough, wheezing, and difficulty breathing that has worsened over the past two days. The child has a known history of eczema and multiple food allergies, including peanuts and eggs. On examination, the child appears in mild respiratory distress with nasal flaring and intercostal retractions. Auscultation of the chest reveals bilateral wheezing. The child is afebrile, with a respiratory rate of 40 breaths per minute, heart rate of 120 bpm, and oxygen saturation of 94% on room air. A chest X-ray shows hyperinflation but no focal consolidation. Which of the following is the most likely diagnosis?

A. Bronchiolitis
B. Cystic fibrosis
C. Foreign body aspiration
D. Asthma
E. Pneumonia
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A 35-year-old woman presents to the emergency department with a 3-day history of fever, chills, and a productive cough with greenish sputum. She has a history of asthma and is currently on inhaled corticosteroids. On examination, her temperature is 38.5°C, blood pressure is 120/80 mmHg, heart rate is 110 bpm, and respiratory rate is 24 breaths per minute. Auscultation of the chest reveals wheezing and crackles in the right lower lung field. A chest X-ray shows consolidation in the right lower lobe. What is the most appropriate initial antibiotic therapy for this patient, considering her asthma and current presentation?

A. Azithromycin
B. Amoxicillin-clavulanate
C. Ciprofloxacin
D. Levofloxacin
E. Doxycycline
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A 28-year-old woman presents to the clinic with a 2-week history of fever, night sweats, and a non-productive cough. She has recently returned from a trip to rural Queensland. On examination, she has crackles in the right upper lung field. A chest X-ray shows a cavitary lesion in the right upper lobe. What is the most likely diagnosis?

A. Tuberculosis
B. Lung abscess
C. Pulmonary embolism
D. Sarcoidosis
E. Pneumonia
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A 65-year-old man with a history of COPD presents with fever, productive cough, and shortness of breath for 3 days. On examination, he has crackles in the right lower lung field. A chest X-ray shows a right lower lobe consolidation. What is the most likely diagnosis?

A. Tuberculosis
B. Lung cancer
C. Heart failure
D. Pulmonary embolism
E. Community-acquired pneumonia
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 30-year-old recent immigrant from a high-TB prevalence country presents with a persistent cough and night sweats for 2 months. Sputum cultures are negative for acid-fast bacilli. A PET-CT scan was performed, and an image is shown. What is the MOST appropriate next step in management?

A. Repeat sputum cultures in one week
B. Initiate anti-tuberculosis therapy
C. Prescribe a course of broad-spectrum antibiotics
D. Order a bronchoscopy with biopsy
E. Start the patient on corticosteroids
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A 60-year-old woman presents to the clinic with a 2-month history of progressive shortness of breath and a dry cough. She has a history of rheumatoid arthritis and is currently on methotrexate and low-dose prednisone. On examination, she has fine inspiratory crackles at the lung bases. A high-resolution CT scan of the chest shows reticular opacities and honeycombing predominantly in the lower lobes. What is the most likely diagnosis?

A. Chronic obstructive pulmonary disease (COPD)
B. Congestive heart failure
C. Pulmonary embolism
D. Interstitial lung disease secondary to rheumatoid arthritis
E. Pneumonia
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X-ray of hiatal hernia
Image by Ahmed Farhat, Daryn Towle CC BY 4.0 · Source

An 82-year-old patient presents with a 6-month history of chronic cough, intermittent dyspnea, and occasional regurgitation, particularly when lying flat. They deny significant chest pain or weight loss. Past medical history includes well-controlled hypertension and mild asthma managed with salbutamol PRN. On examination, vital signs are stable, and lung sounds are clear with no wheeze. An outpatient chest X-ray was performed as part of the workup for the cough and dyspnea. Considering the radiographic findings in conjunction with the clinical history, which of the following investigations is most appropriate at this stage?

A. High-resolution CT chest
B. Oesophago-gastro-duodenoscopy (OGD)
C. Pulmonary function tests
D. 24-hour oesophageal pH monitoring
E. Cardiac stress test
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 32-year-old male, recent immigrant from a high-TB prevalence country, presents with a persistent cough and night sweats for the past two months. He denies fever or weight loss. Physical examination is unremarkable except for mild scattered rhonchi on auscultation. Sputum cultures are negative for acid-fast bacilli. A PET-CT scan of the chest is performed, the axial view is shown. Given the clinical context and imaging findings, what is the MOST appropriate next step in management?

A. Schedule a follow-up chest X-ray in 6 weeks to monitor for changes
B. Repeat sputum cultures for acid-fast bacilli with liquid media
C. Order a bronchoscopy with transbronchial biopsy of the lesion
D. Initiate a multi-drug anti-tuberculosis therapy regimen
E. Prescribe a course of broad-spectrum antibiotics for presumed bacterial pneumonia
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A 45-year-old man presents to the clinic with a 3-month history of persistent cough, night sweats, and weight loss. He has a history of smoking and works as a miner. On examination, he has decreased breath sounds and dullness to percussion over the right upper lobe. A chest X-ray shows a cavitary lesion in the right upper lobe. What is the most likely diagnosis?

A. Pulmonary tuberculosis
B. Chronic obstructive pulmonary disease (COPD)
C. Pneumonia
D. Lung cancer
E. Sarcoidosis
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A 45-year-old man presents to the clinic with a 3-month history of persistent cough and shortness of breath. He is a non-smoker and works as a carpenter. On examination, there are bilateral inspiratory crackles at the lung bases. A chest X-ray shows reticular opacities predominantly in the lower lobes. Pulmonary function tests reveal a restrictive pattern. What is the most likely diagnosis?

A. Bronchiectasis
B. Asthma
C. Idiopathic pulmonary fibrosis
D. Chronic obstructive pulmonary disease
E. Sarcoidosis
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A 59-year-old lady with a past history of Type 2 Diabetes Mellitus and hypertension, and no smoking history, presents with a 3-month history of cough, blood-tinged sputum, night sweats, and a 5 kg weight loss. What are the most appropriate initial investigations for the likely diagnosis?

A. CXR + 3 AFB sputum samples
B. Full blood count and inflammatory markers.
C. Bronchoscopy with biopsy.
D. IGRA
E. CT chest
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A 70-year-old man with severe COPD (FEV1 35%) presents with increased cough, purulent sputum, and dyspnoea over 48 hours. He uses salbutamol PRN and tiotropium daily. His oxygen saturation is 88% on room air. Chest X-ray shows hyperinflation but no new consolidation. What is the most appropriate initial management step?

A. Administer controlled oxygen therapy targeting SpO2 88-92%.
B. Perform arterial blood gas analysis.
C. Initiate intravenous antibiotics.
D. Prescribe high-dose inhaled corticosteroids.
E. Administer nebulised salbutamol and ipratropium bromide.
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A 4-year-old boy is brought to the pediatrician by his parents due to a persistent cough and wheezing for the past two weeks. The symptoms started after he had a cold. He has no significant past medical history and is up to date with his vaccinations. On examination, he is afebrile, with mild respiratory distress and bilateral wheezing on auscultation. What is the most appropriate initial treatment?

A. Inhaled salbutamol
B. Observation and reassurance
C. Oral corticosteroids
D. Oral antibiotics
E. Inhaled corticosteroids
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A 62-year-old woman presents to her general practitioner with a 3-month history of progressive shortness of breath, fatigue, and a persistent dry cough. She has a history of rheumatoid arthritis, for which she takes methotrexate and low-dose prednisone. She denies fever, weight loss, or night sweats. On examination, she has clubbing of the fingers and fine inspiratory crackles at the lung bases. Her oxygen saturation is 92% on room air. A chest X-ray shows reticular opacities predominantly in the lower lung zones. Pulmonary function tests reveal a restrictive pattern with reduced diffusion capacity for carbon monoxide (DLCO). Which of the following is the most appropriate next step in the management of this patient?

A. Initiate supplemental oxygen therapy
B. Start azathioprine
C. Refer for lung biopsy
D. Increase the dose of prednisone
E. High-resolution computed tomography (HRCT) of the chest
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A 55-year-old man with a history of hypertension and stable angina is prescribed a new medication. He reports experiencing a persistent dry cough since starting the medication. Which drug is most likely responsible for this side effect?

A. Amlodipine
B. Losartan
C. Enalapril
D. Hydrochlorothiazide
E. Atenolol
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 32-year-old male, originally from a high-TB prevalence country, presents to the emergency department with a persistent cough for the past 3 weeks, night sweats, and a 5 kg weight loss. He denies any fever or shortness of breath. Physical examination reveals normal breath sounds bilaterally, with no wheezes or crackles. His vital signs are stable: temperature 37.2°C, heart rate 88 bpm, blood pressure 120/80 mmHg, and oxygen saturation 98% on room air. A chest X-ray was initially interpreted as showing a possible lung mass, prompting further investigation with a PET-CT scan, the axial view of which is shown. Sputum samples have been sent for microscopy and culture, but results are pending. Given the clinical presentation and the imaging findings, what is the MOST appropriate next step in management?

A. Order a bronchoscopy with bronchoalveolar lavage and transbronchial biopsy
B. Schedule a follow-up PET-CT scan in 3 months to monitor for changes in size and metabolic activity
C. Prescribe a course of broad-spectrum antibiotics to cover community-acquired pneumonia
D. Perform a CT-guided needle biopsy of the lesion for definitive diagnosis
E. Initiate a multi-drug anti-tuberculosis therapy regimen
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A 35-year-old man presents to the clinic with a 3-month history of fatigue, weight loss, and night sweats. He also reports a persistent cough that has recently become productive of blood-streaked sputum. He has no significant past medical history and is not on any medications. He recently returned from a trip to Southeast Asia. On examination, he is febrile and has bilateral crackles in the upper lung fields. A chest X-ray shows cavitary lesions in the upper lobes. What is the most likely diagnosis?

A. Community-acquired pneumonia
B. Chronic obstructive pulmonary disease (COPD)
C. Lung cancer
D. Sarcoidosis
E. Pulmonary tuberculosis
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A 55-year-old man presents to the clinic with a 3-month history of worsening cough, weight loss, and night sweats. He has a 30-pack-year smoking history and worked in construction for 20 years. On examination, he has clubbing of the fingers and decreased breath sounds in the right lower lung field. A chest X-ray shows a right lower lobe mass. What is the most appropriate next step in the management of this patient?

A. Order sputum cytology
B. Perform a PET scan
C. Refer for bronchoscopy
D. Obtain a CT scan of the chest
E. Start empirical antibiotics
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 35-year-old male presents with a two-month history of fatigue, unintentional weight loss, and a persistent dry cough. He denies fever or night sweats. A PET-CT scan of the chest was performed (image shown). What is the MOST appropriate next step in management?

A. Repeat PET-CT in 3 months
B. Initiate anti-tuberculosis therapy
C. Bronchoscopy with biopsy
D. Empiric antibiotic therapy
E. Sputum culture for bacterial pathogens
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A 3-year-old child is brought to the general practice clinic by his parents due to recurrent episodes of wheezing and cough, particularly following viral upper respiratory tract infections. The child has had multiple similar episodes over the past year, each resolving with bronchodilator therapy. There is no history of eczema or allergic rhinitis, and the family history is unremarkable for atopic conditions. On examination, the child appears well between episodes, with normal growth parameters and no signs of respiratory distress. Auscultation of the chest reveals clear lung fields without wheezes or crackles. Which of the following is the most likely underlying condition?

A. Bronchiolitis
B. Viral-induced wheeze
C. Foreign body aspiration
D. Cystic fibrosis
E. Asthma
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A 1-year-old child is brought to the emergency department with a 3-day history of cough, wheezing, and difficulty breathing. The child has a fever of 38.5°C and a runny nose. On examination, the child appears in mild respiratory distress with nasal flaring and intercostal retractions. Auscultation reveals diffuse wheezing and crackles throughout the lung fields. The child has no significant past medical history and is up to date with vaccinations. A chest X-ray shows hyperinflation but no focal consolidation. Which of the following is the most likely diagnosis?

A. Foreign body aspiration
B. Asthma
C. Croup
D. Bronchiolitis
E. Pneumonia
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A 58-year-old woman presents with a 7-year history of chronic cough productive of copious, often purulent, sputum, particularly noticeable in the mornings. She reports requiring 4-5 courses of antibiotics annually for exacerbations of her 'chronic bronchitis'. She is a non-smoker and has no significant past medical history other than childhood measles complicated by pneumonia. On examination, she has scattered coarse crackles bilaterally at the lung bases. Her oxygen saturation is 96% on room air. Spirometry performed 3 months ago showed FEV1 78% predicted, FVC 85% predicted, FEV1/FVC 0.75. A recent chest X-ray was reported as showing 'mild peribronchial thickening'. Given the clinical suspicion, what is the single most appropriate next investigation to establish the diagnosis?

A. Bronchoscopy with bronchoalveolar lavage
B. Sputum culture for bacteria, fungi, and mycobacteria
C. Alpha-1 antitrypsin level
D. High-resolution computed tomography (HRCT) of the chest
E. Pulmonary function tests including lung volumes and diffusion capacity
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X-ray of hiatal hernia
Image by Ahmed Farhat, Daryn Towle CC BY 4.0 · Source

A 68-year-old male with a history of GERD presents with worsening dysphagia and nocturnal cough. An X-ray is performed. Which of the following is the MOST likely underlying mechanism contributing to the patient's dysphagia?

A. Inflammation of the esophageal mucosa
B. Gastric acid hypersecretion
C. Esophageal dysmotility secondary to vagal nerve damage
D. Mechanical obstruction due to esophageal compression
E. Decreased lower esophageal sphincter tone
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A 45-year-old man presents to his general practitioner with a 3-month history of persistent cough and occasional wheezing. He is a non-smoker and works as a carpenter. He reports that his symptoms worsen at work and improve on weekends. He has no significant past medical history and is not on any medications. What is the most likely diagnosis?

A. Viral upper respiratory tract infection
B. Pulmonary fibrosis
C. Chronic obstructive pulmonary disease (COPD)
D. Gastroesophageal reflux disease (GERD)
E. Occupational asthma
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