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Practice targeted AMC-style multiple-choice questions on general practice.

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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 2-year-old child is brought to the GP by their parents who are concerned about the appearance of their child's abdomen. The child is asymptomatic, feeding well, and has no history of vomiting or pain. On examination, vital signs are normal. Considering the clinical presentation and the finding shown in the image, what is the most appropriate initial management?

A. Arrange an urgent abdominal ultrasound.
B. Urgent surgical referral for repair.
C. Application of an abdominal binder or tape.
D. Prescription of paracetamol and review in 3 months.
E. Observation and reassurance, advising review if symptomatic or persistent beyond age 4-5 years.
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 28-year-old female presents with a chronic cough and fatigue. She has no significant past medical history but reports recent travel to Southeast Asia. A chest PET-CT was performed. What is the MOST appropriate next step in the management of this patient?

A. Order a bronchoscopy with biopsy
B. Start a trial of inhaled corticosteroids
C. Repeat the PET-CT scan in 3 months
D. Initiate anti-tuberculosis therapy
E. Prescribe a course of broad-spectrum antibiotics
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 68-year-old male presents with fatigue and weight loss. The provided image was obtained. Which of the following is the MOST appropriate next step in management?

A. Initiate palliative care consultation
B. Percutaneous ethanol ablation of selected lesions
C. Referral to medical oncology for systemic therapy
D. Surgical resection of the largest lesion
E. Repeat imaging in 3 months to assess progression
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Inguinal hernia right view. Adult male with an inguinal hernia, showing bulging in the groin area.
Image by IkeTheSloth CC0 1.0 · Source

A 55-year-old male presents to his GP complaining of a swelling in his right groin that has been present for several months. He states it is more noticeable when he is standing or coughing and sometimes causes a dull ache, but it is easily pushed back in when he lies down. He denies any fever, nausea, or acute pain. His vital signs are stable. Physical examination reveals the finding shown in the image. Considering the patient's history and the physical examination finding depicted, what is the most appropriate next step in management?

A. Recommend a trial of a supportive truss garment.
B. Referral for elective surgical repair.
C. Request an urgent ultrasound of the groin.
D. Advise watchful waiting and provide analgesia as needed.
E. Immediate surgical consultation for suspected incarceration.
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A 32-year-old woman presents to the clinic with a 2-week history of a persistent cough and shortness of breath. She has no significant past medical history and is a non-smoker. On examination, she has bilateral wheezing and reduced breath sounds. A chest X-ray shows hyperinflation of the lungs. What is the most likely diagnosis?

A. Chronic obstructive pulmonary disease (COPD)
B. Asthma
C. Heart failure
D. Pneumonia
E. Pulmonary embolism
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A 62-year-old male presents to his general practitioner with a six-month history of a painless bulge in his right groin. On examination, a soft swelling is palpable in the right inguinal region, which increases in size on coughing or straining. The swelling is located medial to the inferior epigastric vessels. Which of the following is the most appropriate initial management strategy according to current Australian guidelines?

A. Reassurance and watchful waiting, with advice to return if symptoms worsen.
B. Urgent referral to an emergency department for exclusion of strangulation.
C. Prescription of a truss to provide symptomatic relief.
D. Referral to a physiotherapist for core strengthening exercises.
E. Referral to a general surgeon for consideration of elective repair.
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Umbilical hernia
Image by Ibrahim Husain Meraj CC BY-SA 4.0 · Source

A 3-year-old child is brought to the GP by their parents who are worried about the appearance of their child's abdomen, as shown in the image. The child is otherwise well, active, and has no pain, vomiting, or changes in bowel habits. On examination, the finding is soft and easily reducible. Vital signs are normal. Based on this presentation and the image, what is the most appropriate initial management?

A. Application of a binder or tape over the area.
B. Advise strict bed rest to prevent worsening.
C. Request an abdominal ultrasound to assess contents.
D. Reassurance and observation for spontaneous closure.
E. Urgent surgical referral for repair.
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A 45-year-old man presents to the general practice clinic with a 3-month history of fatigue, weight loss, and night sweats. He has a history of smoking and works as a construction worker. On examination, he has cervical lymphadenopathy and hepatosplenomegaly. Blood tests reveal anemia and elevated lactate dehydrogenase (LDH). A chest X-ray shows a mediastinal mass. What is the most appropriate next step in the management of this patient?

A. Initiate corticosteroid therapy
B. Start empirical antibiotic therapy
C. Order a CT scan of the chest and abdomen
D. Perform a lymph node biopsy
E. Refer for surgical excision of the mass
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A 28-year-old man presents to his general practitioner for a routine health check. He reports being in a non-monogamous relationship for the past year. He states he uses condoms inconsistently, particularly within the primary relationship where his partner's HIV status is unknown. He denies any recent febrile illness, rash, or lymphadenopathy. His last HIV test, performed 6 months ago, was negative. He has no other significant medical history. Considering his presentation and reported risk factors, which of the following is the most appropriate next step in his management according to Australian guidelines?

A. Order a comprehensive panel of sexually transmitted infection tests, excluding HIV, and review results.
B. Advise strict and consistent condom use for all sexual encounters.
C. Schedule a repeat HIV test in 6 months as part of routine screening.
D. Prescribe a course of post-exposure prophylaxis (PEP) immediately.
E. Discuss and offer HIV pre-exposure prophylaxis (PrEP) after confirming negative HIV status.
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A 28-year-old woman with a mother diagnosed with colorectal cancer at 45 and a maternal uncle at 50 seeks advice. She is otherwise well. What is the most appropriate next step in her management?

A. Annual FIT testing.
B. Consider prophylactic colectomy.
C. Genetic counselling and testing.
D. Colonoscopy screening at 40.
E. Reassurance and review.
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A 48-year-old woman, who emigrated from Southeast Asia 5 years ago, presents to her general practitioner with a 3-month history of a slowly enlarging lump in her neck. She reports mild fatigue and has lost approximately 3 kg unintentionally over the same period. She denies cough, fever, or night sweats. Her past medical history includes well-controlled type 2 diabetes mellitus managed with metformin. She is a non-smoker and drinks alcohol occasionally. On examination, she has a firm, non-tender, mobile mass measuring approximately 3x4 cm in the left anterior cervical chain. There are no other palpable lymph nodes. Chest auscultation is clear. Abdominal examination is unremarkable. Initial blood tests show a haemoglobin of 118 g/L (normal 120-150), white cell count 7.8 x 10^9/L (normal 4-11), neutrophils 4.5 x 10^9/L, lymphocytes 2.8 x 10^9/L, CRP 15 mg/L (normal <5). Liver and renal function tests are within normal limits. A neck ultrasound confirms a cluster of enlarged, hypoechoic lymph nodes in the left cervical region, the largest measuring 3.5 cm, with some central necrosis noted. A chest X-ray is clear. Given the clinical presentation and investigation findings, what is the most appropriate next diagnostic step?

A. Perform a Mantoux test and Interferon-Gamma Release Assay (IGRA)
B. Order a PET-CT scan to assess for other sites of disease or malignancy
C. Excisional biopsy of the lymph node for histopathology and culture
D. Fine needle aspiration of the lymph node for Ziehl-Neelsen stain, culture, and PCR
E. Initiate empirical treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol
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A 48-year-old sheep farmer presents to his GP with a two-week history of persistent fever, severe retro-orbital headache, and profound fatigue. He denies cough, shortness of breath, or rash. On examination, his temperature is 38.5°C, pulse 85 bpm, BP 120/80 mmHg. The remainder of the examination, including chest auscultation, is unremarkable. He has not travelled outside the region recently.

A. Acute Q fever
B. Atypical pneumonia
C. Leptospirosis
D. Brucellosis
E. Influenza
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A 23-year-old backpacker doing farm work presents with a low-grade fever for 4 days. Q fever is suspected. What is the most appropriate diagnostic method for acute Q fever in Australia?

A. Chest X-ray
B. Serology (IFA for Phase II antibodies)
C. Serum PCR for C. burnetii.
D. Rapid antigen test for C. burnetii.
E. Serial blood cultures
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A 37-year-old lady presents with a sudden right-sided facial droop, with no ear symptoms or dysphagia. She is 16 weeks pregnant. What is the likely diagnosis?

A. Multiple Sclerosis
B. Schwannoma
C. Stroke
D. Ramsay Hunt syndrome
E. Bell's palsy
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 62-year-old male with a history of poorly controlled diabetes presents with right upper quadrant pain, fever, and night sweats for 3 weeks. He is on immunosuppressants following a renal transplant 5 years ago. Blood cultures are pending. Imaging is performed, as shown. What is the MOST appropriate next step in management?

A. Percutaneous drainage and antibiotics
B. Observation and serial imaging
C. Metronidazole and supportive care
D. Empiric amphotericin B
E. Albendazole and surgical resection
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A 62-year-old Aboriginal and Torres Strait Islander man presents for a routine check-up. He has a history of smoking, obesity, and type 2 diabetes, managed with metformin. His blood pressure is 150/90 mmHg. Which of the following is the MOST significant modifiable risk factor for cardiovascular disease in this patient?

A. Type 2 diabetes
B. Smoking
C. Obesity
D. Indigenous status
E. Hypertension
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A 62-year-old female has high blood pressure (162/97 mmHg) but is not concerned. She has white coat hypertension and declines 24-hour BP monitoring. What is the correct instruction about home blood pressure readings?

A. Check blood pressure immediately after waking up.
B. Check BP before daily medications.
C. Check blood pressure while talking or watching TV.
D. Check blood pressure only when feeling unwell.
E. Check blood pressure after food and exercise.
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Facial eosinophilic granuloma. Red-brown nodule on the nose. Clearly visible follicular structures ("peau d'orange").
Image by Sand, Michael, et al. CC BY 2.0 · Source

A 35-year-old man presents to his general practitioner reporting a lesion on his nose that he first noticed approximately three months ago. He describes it as initially resembling a persistent pimple, but notes it has not resolved and appears to be slowly increasing in size. He denies any associated pain, itching, or bleeding from the site. His past medical history is unremarkable, and he is not currently taking any regular medications. He works outdoors in a role involving significant sun exposure but admits to inconsistent use of sun protection measures. On physical examination, his vital signs are within normal limits. The lesion in question is located on his nose and has the appearance shown in the accompanying image. No other suspicious skin lesions are identified elsewhere on his body, and regional lymph nodes are not palpable. Considering the clinical presentation and the appearance of the lesion depicted, what is the most appropriate initial step in the management of this patient?

A. Perform a punch biopsy of the lesion for histological examination.
B. Arrange an urgent ultrasound scan of the nose and regional lymph nodes to assess for depth and spread.
C. Prescribe a course of topical antibiotic cream and review in two weeks.
D. Advise the patient to monitor the lesion for further changes and return in three months if it persists or grows.
E. Initiate treatment with a high-potency topical corticosteroid cream twice daily.
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A 72-year-old man with a history of hypertension, type 2 diabetes, and chronic kidney disease (CKD) presents to his general practitioner for a routine check-up. His current medications include metformin, insulin, amlodipine, and aspirin. His blood pressure today is 150/90 mmHg. Laboratory results show a serum creatinine of 2.5 mg/dL (221 micromol/L) and a potassium level of 5.4 mEq/L. The GP decides to add an ACE inhibitor to his treatment regimen to help manage his blood pressure and provide renal protection. One week later, the patient returns complaining of fatigue and muscle weakness. Repeat laboratory tests reveal a serum creatinine of 3.1 mg/dL (274 micromol/L) and a potassium level of 6.2 mEq/L. Which of the following is the most appropriate next step in managing this patient?

A. Add a potassium-binding resin (e.g., sodium polystyrene sulfonate) and continue the ACE inhibitor.
B. Prescribe a loop diuretic to counteract the hyperkalemia and continue the ACE inhibitor.
C. Refer the patient to a nephrologist for urgent dialysis.
D. Reduce the dose of the ACE inhibitor by 50% and recheck renal function and potassium levels in one week.
E. Discontinue the ACE inhibitor and monitor renal function and potassium levels.
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 68-year-old woman presents with 3 days of left lower quadrant pain. She reports mild nausea but no vomiting or fever. On examination, she is afebrile, BP 130/80, HR 78, O2 sat 98% on air. There is localised tenderness in the LLQ. Bloods show WCC 13.2, CRP 45. A CT scan is performed. Considering the clinical presentation and the findings demonstrated in the image, what is the most appropriate initial management plan?

A. Discharge with analgesia and advice to return if symptoms worsen, without antibiotics.
B. Outpatient management with oral antibiotics and analgesia.
C. Admission for intravenous antibiotics and observation.
D. Urgent colonoscopy to assess the extent of disease.
E. Surgical consultation for potential colectomy.
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An incarcerated inguinal hernia as seen on CT
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 72-year-old male presents with a painful, irreducible right groin mass. He reports vomiting and abdominal distension. His vitals are: HR 110, BP 100/60, RR 22, SpO2 96% RA. The provided image was obtained. What is the next step?

A. Attempt manual reduction with sedation
B. Surgical consultation for emergent repair
C. Order a repeat CT scan with contrast in 6 hours
D. Start a clear liquid diet
E. Administer intravenous antibiotics
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A 45-year-old man presents to his GP with a 3-month history of gradually enlarging, painless swelling in the left side of his neck. He denies fever, night sweats, or weight loss. He emigrated from a region with high tuberculosis prevalence five years ago and has no known history of TB exposure or prior testing. On examination, there are multiple firm, non-tender, discrete lymph nodes in the left posterior triangle of the neck, the largest measuring about 3 cm. There are no other palpable nodes or organomegaly. His chest X-ray is clear. What is the most appropriate next diagnostic step?

A. Order a CT scan of the neck to assess the extent of lymphadenopathy
B. Fine needle aspiration cytology and mycobacterial culture of the affected lymph node
C. Perform an Interferon-gamma release assay (IGRA)
D. Initiate empirical treatment with a broad-spectrum antibiotic
E. Excisional biopsy of the largest lymph node for histopathology
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Acute cholecystitis with gallbladder wall thickening, a large gallstone, and a large gallbladder
Image by James Heilman, MD CC BY-SA 4.0 · Source

A 45-year-old female presents to the emergency department with a 3-day history of right upper quadrant pain, nausea, and subjective fevers. She reports that the pain is constant and worsened by eating. She has no significant past medical history and takes no medications. On examination, she is noted to be uncomfortable, with a temperature of 38.2°C, heart rate of 110 bpm, blood pressure of 130/80 mmHg, and an oxygen saturation of 99% on room air. Abdominal examination reveals marked tenderness to palpation in the right upper quadrant with guarding. Murphy's sign is positive. Laboratory investigations reveal a white blood cell count of 15,000/µL with neutrophilic predominance, total bilirubin of 1.8 mg/dL, alkaline phosphatase of 280 U/L, ALT of 160 U/L, and AST of 130 U/L. The provided image was obtained. Considering the clinical presentation and the findings on the image, which of the following is the MOST appropriate next step in management?

A. Order a hepatobiliary iminodiacetic acid (HIDA) scan
B. Administer analgesics and antiemetics, and discharge home with outpatient follow-up
C. Perform an ERCP to rule out choledocholithiasis
D. Initiate intravenous antibiotics and observe for 48 hours
E. Surgical consultation for cholecystectomy
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A 45-year-old woman presents to her general practitioner with a 3-month history of persistent cough and occasional wheezing. She has a history of asthma, which has been well-controlled with inhaled corticosteroids. She denies any recent respiratory infections or changes in her medication. On examination, her vital signs are normal, and there are scattered wheezes on auscultation. Spirometry shows a reduced FEV1/FVC ratio that improves significantly after bronchodilator administration. What is the most appropriate next step in the management of this patient?

A. Increase the dose of inhaled corticosteroids
B. Start oral corticosteroids
C. Refer for allergy testing
D. Add a long-acting beta-agonist (LABA)
E. Prescribe a leukotriene receptor antagonist
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A 52-year-old woman presents to her GP with a palpable lump in her right breast. She reports no pain, nipple discharge, or skin changes. She has no family history of breast cancer. On examination, the lump is firm, non-tender, and mobile. There is no axillary lymphadenopathy. What is the most appropriate initial investigation?

A. Breast ultrasound
B. Mammography
C. Fine-needle aspiration (FNA)
D. MRI of the breast
E. Core biopsy
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A 55-year-old non-smoker with no known comorbidities has a consistent office BP of 155/98 mmHg. His 10-year CVD risk is calculated as low. According to Australian guidelines, what is the most appropriate initial management?

A. Recommend lifestyle modifications and review in 3-6 months
B. Investigate for secondary causes of hypertension
C. Initiate single antihypertensive therapy
D. Refer for ambulatory blood pressure monitoring
E. Initiate dual antihypertensive therapy
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Right leg affected by warfarin necrosis
Image by Bakoyiannis C, Karaolanis G, Patelis N, Maskanakis A, Tsaples G, Klonaris C, Georgopoulos S, Liakakos T CC BY 4.0 · Source

A patient on warfarin presents with leg pain. INR is 3.5. Given the image, what is the MOST appropriate next step?

A. Stop warfarin and administer vitamin K
B. Elevate the leg and apply warm compresses
C. Continue warfarin at the same dose
D. Apply topical corticosteroids
E. Start heparin and continue warfarin
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A contrast enhanced CT scan demonstrating an abdominal aortic aneurysm of 4.8 * 3.8 cm
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 72-year-old male with a history of hypertension and hyperlipidemia presents for a routine follow-up. He is asymptomatic. A contrast-enhanced CT abdomen, axial view shown, was performed as part of a screening protocol. What is the MOST appropriate next step?

A. Initiate beta-blocker therapy
B. Prescribe a statin for lipid management
C. Start aspirin for antiplatelet therapy
D. Repeat imaging in 6-12 months
E. Refer for immediate surgical repair
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A 55-year-old woman presents to her GP with a 3-month history of fatigue, pallor, and shortness of breath on exertion. She has a history of menorrhagia. On examination, she appears pale and has conjunctival pallor. Blood tests reveal a hemoglobin level of 8 g/dL, mean corpuscular volume (MCV) of 70 fL, and low serum ferritin. What is the most appropriate next step in management?

A. Arrange for a blood transfusion
B. Refer for a colonoscopy
C. Prescribe erythropoietin
D. Start oral iron supplementation
E. Order a bone marrow biopsy
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 55-year-old man presents with the condition depicted, which has been present for 12 months and is mildly tender. Initial investigations including hormonal profile, liver function tests, and renal function tests are unremarkable. He takes no regular medications. Considering the clinical presentation and the findings shown, what is the most appropriate next step in the management of this patient?

A. Referral for surgical reduction mammoplasty.
B. Prescription of tamoxifen for symptom relief.
C. Further investigation for rare endocrine causes (e.g., hCG-producing tumour).
D. Urgent referral for breast imaging (ultrasound/mammography).
E. Reassurance and observation with review as needed.
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A 56-year-old gentleman, a gardener and cat owner, presents with 24 hours of pain, swelling, and redness on his right index finger. His temperature is 38.1°C and pulse is 72. Suspected gout. What is the most appropriate next step?

A. Aspirate joint for microscopy and culture.
B. Urgent hospital referral for drainage and IV antibiotics.
C. Prescribe oral antibiotics and review in 24 hours.
D. Start diclofenac TDS and discuss allopurinol.
E. Order serum uric acid level.
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 30-year-old recent immigrant from a high-TB prevalence country presents with a persistent cough and night sweats for 2 months. Sputum cultures are negative for acid-fast bacilli. A PET-CT scan was performed, and an image is shown. What is the MOST appropriate next step in management?

A. Repeat sputum cultures in one week
B. Initiate anti-tuberculosis therapy
C. Prescribe a course of broad-spectrum antibiotics
D. Order a bronchoscopy with biopsy
E. Start the patient on corticosteroids
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A 45-year-old farmer presents with a 10-day history of fever, severe retro-orbital headache, and myalgia. He denies cough or dyspnoea. Physical examination is unremarkable. What is the most appropriate initial investigation?

A. Liver function tests
B. Serology for Coxiella burnetii
C. Chest X-ray
D. Blood culture
E. PCR for Coxiella burnetii
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 62-year-old male presents with left lower quadrant pain, fever, and leukocytosis. A CT scan of the abdomen and pelvis is performed (image attached). Assuming the diagnosis, which of the following is the MOST appropriate initial management?

A. Colonoscopy to rule out malignancy
B. Oral antibiotics and outpatient follow-up
C. IV antibiotics, bowel rest, and surgical consultation
D. Stool culture and empiric antibiotics
E. High-fiber diet and increased fluid intake
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A 32-year-old woman presents to her general practitioner with a 2-week history of fatigue, joint pain, and a facial rash that worsens with sun exposure. She also reports hair loss and oral ulcers. Laboratory tests reveal anemia, leukopenia, and positive antinuclear antibodies (ANA). What is the most likely diagnosis?

A. Systemic lupus erythematosus (SLE)
B. Sjogren's syndrome
C. Psoriatic arthritis
D. Rheumatoid arthritis
E. Dermatomyositis
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Elective abdominal ultrasonography of a 64 year old woman with past colicky pain but no current pain. It shows a mildly dilated common bile duct with what appears to be a gallstone (black arrow). The green and blue dots are blood flow, since the exam is done as a Doppler ultrasound to distinguish the bile duct from blood vessels.
Image by Mikael Häggström CC0 1.0 · Source

A 64-year-old woman presents for a routine health check. She reports intermittent episodes of colicky abdominal pain over the past year, which have since resolved. An abdominal ultrasound, as shown, was performed. Liver function tests are normal. Which of the following is the MOST appropriate next step in management?

A. Ursodeoxycholic acid therapy
B. Hepatobiliary iminodiacetic acid (HIDA) scan
C. Referral for elective cholecystectomy
D. Observation with repeat ultrasound in 6 months
E. ERCP with sphincterotomy
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A 62-year-old man with a history of poorly controlled hypertension and type 2 diabetes mellitus presents to his general practitioner for a routine check-up. His current medications include metformin, gliclazide, and amlodipine. His blood pressure today is 160/95 mmHg. His creatinine is 140 umol/L (previously 110 umol/L). His electrolytes are normal. The GP decides to add an ACE inhibitor to his regimen. Which of the following investigations is MOST important to repeat within 1-2 weeks of commencing the ACE inhibitor?

A. Full blood count
B. Fasting blood glucose
C. Serum creatinine and electrolytes
D. Urine albumin creatinine ratio
E. Liver function tests
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A 40-year-old Aboriginal man presents for a health check. He reports feeling well but has a strong family history of diabetes and cardiovascular disease. What is the most appropriate initial screening test?

A. PSA
B. Full blood count
C. Fasting blood glucose and lipid profile
D. ECG
E. Urine albumin creatinine ratio
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A 58-year-old man presents to his general practitioner with a 3-week history of intermittent fever, severe headache, and profound fatigue. He describes the headache as diffuse and often retro-orbital, not relieved by simple analgesia. He also reports generalised muscle aches and occasional night sweats. He denies cough, shortness of breath, or gastrointestinal symptoms. His medical history is unremarkable, and he takes no regular medications. He lives on a rural property in Queensland where he raises sheep and cattle. On examination, he is afebrile at the time of consultation (37.2°C), blood pressure is 130/80 mmHg, pulse is 85 bpm, and respiratory rate is 16 breaths per minute. Physical examination is otherwise unremarkable; specifically, there is no rash, lymphadenopathy, or focal neurological signs. Initial laboratory investigations reveal a white cell count of 7.5 x 10^9/L (neutrophils 65%, lymphocytes 25%), haemoglobin 145 g/L, platelets 250 x 10^9/L. Liver function tests show AST 85 U/L (normal <40), ALT 90 U/L (normal <40), alkaline phosphatase 110 U/L (normal <130), total bilirubin 15 µmol/L (normal <20). C-reactive protein is elevated at 45 mg/L (normal <5). A chest X-ray performed a week prior was reported as normal. Given the clinical presentation and epidemiological context, which of the following is the most appropriate initial diagnostic investigation?

A. Viral serology panel (including CMV, EBV, Hepatitis A, B, C)
B. Serology for Coxiella burnetii (phase I and II antibodies)
C. Lumbar puncture for CSF analysis
D. Abdominal ultrasound
E. Blood cultures
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A 32-year-old woman presents to her general practitioner complaining of severe anal pain during and after bowel movements, along with bright red blood on the toilet paper. She reports constipation and straining during defecation. Examination reveals a visible longitudinal tear in the anal mucosa at the 6 o'clock position. Which of the following is the MOST appropriate initial management strategy, according to Australian guidelines?

A. Recommend regular sitz baths with antiseptic solution.
B. Prescribe oral antibiotics to treat potential infection.
C. Advise increased fluid and fibre intake, stool softeners, and topical application of a local anaesthetic and a topical nitrate ointment.
D. Refer for surgical lateral internal sphincterotomy.
E. Order a colonoscopy to rule out inflammatory bowel disease.
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Endoscopy image of colon adenocarcinoma in sigmoid colon.
Image by Unknown CC BY-SA 3.0 · Source

A 68-year-old male presents to his GP complaining of a change in bowel habit over the past 6 months. He reports increasing constipation alternating with episodes of diarrhea. He also mentions unintentional weight loss of approximately 5 kg during this period. He denies any family history of bowel cancer. A colonoscopy was performed, and a representative image is shown. Assuming the lesion is confirmed as malignant, what is the MOST appropriate next step in the management of this patient?

A. Referral for palliative care
B. Repeat colonoscopy in 3 years
C. CT scan of the chest, abdomen, and pelvis
D. Initiate adjuvant chemotherapy with FOLFOX
E. Administer a course of broad-spectrum antibiotics
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A contrast enhanced CT scan demonstrating an abdominal aortic aneurysm of 4.8 * 3.8 cm
Image by James Heilman, MD CC BY-SA 3.0 · Source

An 68-year-old man attends his GP for a routine check-up. He has a history of well-controlled type 2 diabetes, hypertension, and smoked for 30 years, quitting 5 years ago. He denies any abdominal pain, back pain, or pulsatile sensation. Physical examination is unremarkable. As part of a cardiovascular risk assessment, an abdominal ultrasound is initially performed, which is inconclusive due to bowel gas. A follow-up contrast-enhanced CT scan is arranged. Considering the findings demonstrated in the image, what is the most appropriate next step in the management of this patient?

A. No further action required, reassure the patient
B. Immediate admission for urgent surgical assessment
C. Referral for elective surgical repair
D. Repeat CT scan in 3 months
E. Six-monthly abdominal ultrasound surveillance
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A contrast enhanced CT scan demonstrating an abdominal aortic aneurysm of 4.8 * 3.8 cm
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 68-year-old male presents for a routine check-up. He has a history of smoking and hypertension, well-controlled with medication. He denies any abdominal pain, back pain, or lower extremity claudication. Physical exam is unremarkable. A contrast-enhanced CT scan of the abdomen is performed, the axial view is shown. What is the MOST appropriate next step in management?

A. Referral for immediate surgical repair
B. Repeat imaging in 6-12 months
C. Start aspirin for secondary prevention
D. Initiate beta-blocker therapy
E. Prescribe a statin for lipid management
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 45-year-old male, who recently immigrated from India, presents to his primary care physician with a two-month history of progressive fatigue, unintentional weight loss of 7 kg, and intermittent night sweats. He denies any cough, chest pain, or shortness of breath. He has no significant past medical history and is not currently taking any medications. Physical examination reveals normal vital signs, including a temperature of 37.1°C, and clear breath sounds bilaterally. However, mild cervical lymphadenopathy is noted. Initial laboratory investigations, including a complete blood count and comprehensive metabolic panel, are unremarkable. A chest X-ray reveals a solitary pulmonary nodule in the right upper lobe, which prompts a PET-CT scan for further evaluation. An axial slice from the PET-CT is shown. Given the patient's clinical presentation, immigration history, and the PET-CT findings, which of the following is the MOST appropriate next step in establishing a definitive diagnosis?

A. Bronchoscopy with transbronchial needle aspiration of the lesion
B. Administer a purified protein derivative (PPD) skin test
C. Order a CT-guided percutaneous needle biopsy of the lung nodule
D. Repeat PET-CT scan in three months to assess for interval growth
E. Initiate empiric antibiotic therapy with a broad-spectrum antibiotic
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Mammogram microcalcifications in carcinoma in situ, CC, details
Image by Jmarchn CC BY-SA 3.0 · Source

A 62-year-old woman presents for routine mammography. The image is shown. What is the MOST appropriate next step?

A. Reassurance and routine screening
B. Stereotactic core biopsy
C. Ultrasound of the breast
D. MRI of the breast
E. Excisional biopsy
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A 50-year-old man presents to the general practice with a 3-month history of persistent heartburn and regurgitation, especially after meals. He has tried over-the-counter antacids with minimal relief. He denies any weight loss, dysphagia, or gastrointestinal bleeding. What is the most appropriate next step in the management of this patient?

A. Prescribe H2 receptor antagonists
B. Refer to a gastroenterologist
C. Order an upper endoscopy
D. Advise dietary modifications only
E. Start a proton pump inhibitor
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Diverticulitis in the left lower quadrant. There is outpouching of the colonic wall, wall thickening, and surrounding fat stranding.
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 65-year-old male presents with acute LLQ pain. The provided image was obtained. What dietary advice is most appropriate upon resolution of acute symptoms?

A. Low-residue diet
B. Gluten-free diet
C. Lactose-free diet
D. Elemental diet
E. High-fibre diet
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A 25-year-old woman presents to the clinic with a 2-week history of fatigue, sore throat, and swollen glands. She also reports a low-grade fever and mild headache. On examination, she has cervical lymphadenopathy and mild splenomegaly. A monospot test is positive. What is the most appropriate advice regarding her physical activity?

A. Engage in light exercise to improve symptoms
B. Resume normal activities immediately
C. Start a course of corticosteroids to reduce symptoms
D. Avoid all physical activity for 6 months
E. Avoid contact sports for at least 4 weeks
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Gynaecomastia
Image by ProloSozz CC BY-SA 4.0 · Source

A 58-year-old man presents with concerns about breast enlargement over the past year. He denies pain or tenderness. He takes medication for hypertension. Examination reveals the findings in the image. Which of the following is the MOST appropriate initial investigation?

A. Mammogram and ultrasound
B. Medication review and hormonal blood tests (testosterone, estradiol, LH, FSH)
C. Reassurance and observation
D. Referral to a breast surgeon
E. Fine needle aspiration
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A 72-year-old man with a history of a reducible inguinal hernia presents to the emergency department with severe groin pain and a firm, tender mass in the right inguinal region. He reports that he has been unable to reduce the hernia despite his usual maneuvers. He also reports nausea and vomiting for the past 6 hours. On examination, his vital signs are stable, but he appears uncomfortable. The mass in his groin is erythematous and exquisitely tender to palpation. Which of the following is the most appropriate next step in management?

A. Administration of intravenous antibiotics and observation
B. Surgical exploration
C. CT scan of the abdomen and pelvis with intravenous contrast
D. Attempt manual reduction with sedation and analgesia
E. Ultrasound of the groin to assess blood flow
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