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Practice targeted AMC-style multiple-choice questions on imaging.

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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 28-year-old female presents with a chronic cough and fatigue. She has no significant past medical history but reports recent travel to Southeast Asia. A chest PET-CT was performed. What is the MOST appropriate next step in the management of this patient?

A. Order a bronchoscopy with biopsy
B. Start a trial of inhaled corticosteroids
C. Repeat the PET-CT scan in 3 months
D. Initiate anti-tuberculosis therapy
E. Prescribe a course of broad-spectrum antibiotics
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 68-year-old male presents with fatigue and weight loss. The provided image was obtained. Which of the following is the MOST appropriate next step in management?

A. Initiate palliative care consultation
B. Percutaneous ethanol ablation of selected lesions
C. Referral to medical oncology for systemic therapy
D. Surgical resection of the largest lesion
E. Repeat imaging in 3 months to assess progression
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Post-embolization arteriogram showing coiled aneurysm (indicated by yellow arrows) of the posteriorcerebral artery with a residual aneurysmal sac.
Image by Promod Pillai, Aftab Karim, Anil Nanda CC BY 2.0 · Source

A 68-year-old male presents with worsening headaches and blurred vision. He underwent endovascular coiling for a posterior cerebral artery aneurysm 6 months ago. The attached image was obtained. Which of the following is the MOST appropriate next step in management?

A. Increase the dose of his antihypertensive medication
B. Initiate aspirin therapy
C. Repeat angiography
D. Order a CT scan of the head without contrast
E. Reassure the patient and schedule a follow-up appointment in 6 months
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X-ray of hiatal hernia
Image by Ahmed Farhat, Daryn Towle CC BY 4.0 · Source

A 72-year-old male presents with increasing dyspnea. He has a history of GORD. The provided image was taken. What is the most appropriate next step?

A. Refer for surgical consultation for fundoplication.
B. Prescribe prokinetic agents to improve gastric emptying.
C. Initiate a trial of PPI therapy and lifestyle modifications.
D. Order a barium swallow study to further evaluate the anatomy.
E. Perform an upper endoscopy to assess for complications.
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 62-year-old male with a history of poorly controlled diabetes presents with fever, RUQ pain, and night sweats for 3 weeks. Initial blood cultures are negative. Imaging is performed, as shown. What is the MOST appropriate next step in management?

A. Albendazole therapy
B. Percutaneous drainage and culture of the lesion
C. Surgical resection of the affected liver segment
D. Empiric broad-spectrum antibiotics
E. Observation with serial imaging
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Fluoroscopic image of common bile duct stone seen at the time of ERCP. The stone is impacted in the distal common bile duct.
Image by Samir धर्म at en.wikipedia CC BY-SA 3.0 · Source

A 62-year-old presents with jaundice and RUQ pain. The image was obtained during ERCP. What is the MOST appropriate next step?

A. Observation with serial LFTs
B. Ursodeoxycholic acid administration
C. Sphincterotomy and stone extraction
D. Cholecystectomy
E. Percutaneous transhepatic cholangiography
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A 75-year-old obese man with a history of hypertension and chronic lower limb skin changes, swelling, tingling, and weakness presents with sudden onset inability to stand or move his legs, accompanied by a loss of sensation extending up to his waist. On examination, he has flaccid paralysis of both lower limbs, absent deep tendon reflexes in the legs, and a sensory level at the umbilicus. Which of the following is the most appropriate initial investigation?

A. Urgent MRI of the spine
B. Electromyography and nerve conduction studies
C. CT angiography of the aorta and iliac arteries
D. Lumbar puncture
E. Urgent CT scan of the spine
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the ED with left flank pain radiating to his groin. He reports nausea but denies fever or dysuria. Vitals are stable. A point-of-care ultrasound is performed, with the image shown. Assuming no contraindications, what is the MOST appropriate next step in management?

A. Prescribe oral tamsulosin and discharge home
B. Insert an indwelling urinary catheter
C. Consult urology for emergent stent placement
D. Order a non-contrast CT scan of the abdomen and pelvis
E. Administer intravenous ketorolac
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Neuroblastoma, CT of the abdomen
Image by RadsWiki CC BY-SA 3.0 · Source

A 3-year-old presents with a 2-month history of increasing abdominal distension and intermittent pain. Physical examination reveals a firm, non-tender mass in the upper abdomen. Blood tests show mild anaemia. Vitals are stable. This CT scan was performed as part of the initial workup. Considering the clinical presentation and the findings demonstrated in the provided image, which of the following investigations is the most critical next step for accurate staging and risk stratification to guide appropriate management in this paediatric patient?

A. Bone marrow aspirate and trephine biopsy
B. Repeat CT scan of the abdomen in 3 months
C. Urgent surgical resection of the mass
D. Genetic testing for WT1 gene mutation
E. Initiation of empirical chemotherapy
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 62-year-old male with a history of poorly controlled diabetes presents with right upper quadrant pain, fever, and night sweats for 3 weeks. He is on immunosuppressants following a renal transplant 5 years ago. Blood cultures are pending. Imaging is performed, as shown. What is the MOST appropriate next step in management?

A. Empiric antifungal therapy
B. Observation and serial imaging
C. Metronidazole and supportive care
D. Albendazole and surgical resection
E. Percutaneous drainage and antibiotics
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Mammogram microcalcifications in carcinoma in situ, CC, details
Image by Jmarchn CC BY-SA 3.0 · Source

A 62-year-old woman presents for her routine mammogram. She has no personal or family history of breast cancer. She denies any breast pain, nipple discharge, or palpable lumps. Clinical breast exam is unremarkable. Review of her prior mammograms shows stable, scattered fibroglandular densities. The current mammogram is shown. What is the MOST appropriate next step in management?

A. MRI of the breast
B. Stereotactic core biopsy
C. Reassurance and routine screening in 1 year
D. Ultrasound of the breast
E. Excisional biopsy
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A 42-year-old woman, nulliparous, presents to her general practitioner with a palpable lump in her left breast, noticed two weeks ago. She reports some mild, intermittent tenderness associated with the lump, which she initially attributed to her menstrual cycle, but it has persisted. She has no significant family history of breast cancer. On examination, there is a 1.5 cm, firm, mobile lump in the upper outer quadrant. No skin changes or nipple discharge are noted. Axillary nodes are not palpable. She is otherwise well. Which of the following represents the most appropriate initial management step?

A. Reassurance and review in 3 months.
B. MRI of the breast.
C. Fine needle aspiration cytology of the lump.
D. Urgent mammography and ultrasound.
E. Referral to a specialist breast clinic for triple assessment.
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Elective abdominal ultrasonography of a 64 year old woman with past colicky pain but no current pain. It shows a mildly dilated common bile duct with what appears to be a gallstone (black arrow). The green and blue dots are blood flow, since the exam is done as a Doppler ultrasound to distinguish the bile duct from blood vessels.
Image by Mikael Häggström CC0 1.0 · Source

A 64-year-old woman with past colicky pain has the ultrasound shown. LFTs are normal. What is the MOST appropriate next investigation?

A. Hepatobiliary Iminodiacetic Acid (HIDA) scan
B. Endoscopic ultrasound (EUS)
C. MRCP
D. Repeat ultrasound in 3 months
E. CT Abdomen
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Mammogram microcalcifications in carcinoma in situ, CC, details
Image by Jmarchn CC BY-SA 3.0 · Source

A 58-year-old woman presents for her scheduled screening mammogram. She reports no breast lumps, pain, or nipple discharge. Her past medical history includes well-controlled hypertension and osteoarthritis. She has no known family history of breast or ovarian cancer. Physical examination reveals no palpable abnormalities in either breast or axillae. The mammogram is performed, and the image provided is a detail from the craniocaudal view of the left breast. Considering the clinical presentation and the findings demonstrated in the provided image, what is the most appropriate immediate next step in the management of this patient?

A. Repeat mammography in 6 months
B. Ultrasound of the breast
C. Excisional biopsy
D. Referral for genetic counselling and testing
E. Stereotactic core biopsy of the suspicious area
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 35-year-old male presents with left flank pain and dysuria. An ultrasound is performed. What is the MOST appropriate next step in management?

A. Discharge with analgesia and follow-up
B. Increase oral fluid intake and reassess in 24 hours
C. Refer for immediate nephrectomy
D. Non-contrast CT of the abdomen and pelvis
E. Administer intravenous antibiotics
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 32-year-old male, recent immigrant from a high-TB prevalence country, presents with a persistent cough and night sweats for the past two months. He denies fever or weight loss. Physical examination is unremarkable except for mild, diffuse rhonchi on auscultation. Sputum cultures are pending. A PET-CT scan of the chest was performed, the axial view is shown. Given the clinical context and imaging findings, what is the MOST appropriate next step in management?

A. Prescribe a course of broad-spectrum antibiotics for presumed bacterial pneumonia
B. Initiate a four-drug anti-tuberculosis regimen
C. Repeat the PET-CT scan in three months to assess for interval growth
D. Start a course of oral corticosteroids to reduce inflammation
E. Order a bronchoscopy with transbronchial biopsy
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 55-year-old patient with a history of solid organ transplant on immunosuppressive therapy presents with a 2-week history of low-grade fever, malaise, and dull right upper quadrant discomfort. Physical examination is unremarkable except for mild tenderness in the right upper quadrant. Blood tests reveal a CRP of 85 mg/L (normal <5), WCC 11.5 x 10^9/L (normal 4-11), and mildly elevated alkaline phosphatase. Imaging is performed as shown. What is the most appropriate next step in management?

A. Schedule for surgical resection of the lesion
B. Prescribe oral analgesia and monitor symptoms
C. Image-guided percutaneous aspiration or biopsy of the lesion
D. Repeat imaging with contrast-enhanced CT in 1 week
E. Initiate broad-spectrum intravenous antibiotics
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Hypertrophic pyloric stenosis
Image by Adityagupta95 CC0 1.0 · Source

A 4-week-old male presents with non-bilious emesis. An upper GI series is performed (image shown). What acid-base abnormality is MOST likely?

A. Respiratory alkalosis
B. Hyperchloremic metabolic acidosis
C. Normal acid-base status
D. Respiratory acidosis
E. Hypochloremic metabolic alkalosis
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Post-embolization arteriogram showing coiled aneurysm (indicated by yellow arrows) of the posteriorcerebral artery with a residual aneurysmal sac.
Image by Promod Pillai, Aftab Karim, Anil Nanda CC BY 2.0 · Source

A 55-year-old female presents with new onset right homonymous hemianopia 3 months post-aneurysm coiling. Review the image. What is the MOST likely cause?

A. Aneurysm regrowth
B. Arteriovenous malformation
C. Vasospasm
D. Coil migration
E. New aneurysm formation
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 62-year-old male with a history of hepatitis C presents with new onset ascites and right upper quadrant pain. His AFP is markedly elevated. A contrast-enhanced ultrasound is performed, as shown. What is the MOST appropriate next step in management?

A. Surveillance with serial AFP measurements and ultrasound
B. Referral for liver transplant evaluation
C. Percutaneous ethanol ablation
D. Surgical resection
E. Initiation of systemic chemotherapy
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 68-year-old man with known alcoholic cirrhosis presents for routine surveillance. He reports mild fatigue but no other symptoms. Liver function tests are within his baseline. Alpha-fetoprotein is 150 ng/mL (normal <10). The provided images are obtained. Considering the clinical context and the findings demonstrated in the images, what is the most appropriate immediate next step in this patient's management?

A. Referral for liver transplant assessment
B. Initiate treatment with transarterial chemoembolisation (TACE)
C. Percutaneous biopsy of the lesion
D. Commence systemic therapy with Sorafenib
E. Repeat imaging with MRI liver in 4 weeks
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 65-year-old man with chronic hepatitis C and compensated cirrhosis (Child-Pugh A) presents for routine surveillance. His alpha-fetoprotein is 250 ng/mL. He feels well. The provided images are obtained. Considering the clinical context and the findings demonstrated in the images, which of the following management strategies is most likely to be the initial approach for this patient?

A. Liver transplantation
B. Radiofrequency ablation (RFA)
C. Palliative care
D. Systemic chemotherapy
E. Transarterial chemoembolisation (TACE)
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Upright X-ray demonstrating small bowel obstruction
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 68-year-old male presents to the ED with abdominal distension, obstipation, and vomiting. He reports a history of multiple abdominal surgeries. An upright abdominal X-ray is performed. Based on the image, what is the MOST appropriate next step in management?

A. CT abdomen with contrast
B. Increase oral fluid intake
C. Stool softeners
D. Surgical consultation
E. Oral antibiotics
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CT, ultrasonography, SPECT and scintigraphy of intra-thyroid parathyroid adenoma
Image by Mnahi Bin Saeedan, Ibtisam Musallam Aljohani, Ayman Omar Khushaim, Salwa Qasim Bukhari, Salahudin Tayeb Elnaas CC BY 4.0 · Source

A 62-year-old woman presents with fatigue, bone pain, and constipation. Laboratory investigations reveal serum calcium 3.1 mmol/L, parathyroid hormone 180 pg/mL, and elevated 24-hour urine calcium excretion. Imaging studies are performed for pre-operative localisation, the results of which are shown. Considering the clinical context and the findings demonstrated in the images, which surgical approach is MOST likely indicated for definitive management?

A. Targeted parathyroidectomy via hemithyroidectomy
B. Medical management with cinacalcet
C. Minimally invasive parathyroidectomy
D. Bilateral neck exploration
E. Observation with regular calcium monitoring
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A contrast enhanced CT scan demonstrating an abdominal aortic aneurysm of 4.8 * 3.8 cm
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 72-year-old male presents with new onset back pain. His CT is shown. What is the most appropriate initial management?

A. Lifestyle modification advice
B. Commence beta-blocker therapy
C. Repeat imaging in 12 months
D. Prescribe a statin
E. Referral to vascular surgery
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 28-year-old immunocompetent patient presents with a chronic cough and low-grade fever. Initial investigations, including sputum microscopy, are negative. A PET-CT scan was performed (image shown). What is the MOST appropriate next step?

A. Bronchoscopy with biopsy
B. Empiric antibiotic therapy
C. Referral for surgical resection
D. Repeat sputum cultures
E. Initiate anti-tuberculosis therapy
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Upright X-ray demonstrating small bowel obstruction
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 72-year-old male presents with vomiting and abdominal pain. An abdominal X-ray is performed. What is the MOST likely underlying cause?

A. Appendicitis
B. Diverticulitis
C. Volvulus
D. Adhesions from prior surgery
E. Pancreatitis
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 65-year-old male with known alcoholic cirrhosis undergoes surveillance. The provided contrast-enhanced ultrasound was obtained. What is the MOST appropriate next step?

A. Repeat ultrasound in 3 months
B. Liver biopsy
C. Initiate sorafenib
D. Ablation therapy
E. Triphasic CT or MRI
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the ED with left flank pain radiating to his groin. He reports nausea but no vomiting. Vitals are stable. A focused ultrasound is performed, as shown. What is the MOST appropriate next step in management?

A. Discharge with analgesics and follow-up with urology
B. Administer IV antibiotics
C. Non-contrast CT of the abdomen and pelvis
D. Increase oral fluid intake and reassess in 2 hours
E. Refer for immediate surgical intervention
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A contrast enhanced CT scan demonstrating an abdominal aortic aneurysm of 4.8 * 3.8 cm
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 72-year-old male with a history of hypertension and hyperlipidemia presents for a routine follow-up. He is asymptomatic. A contrast-enhanced CT abdomen, axial view shown, was performed as part of a screening protocol. What is the MOST appropriate next step?

A. Initiate beta-blocker therapy
B. Prescribe a statin for lipid management
C. Start aspirin for antiplatelet therapy
D. Repeat imaging in 6-12 months
E. Refer for immediate surgical repair
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Mammogram microcalcifications in carcinoma in situ, CC, details
Image by Jmarchn CC BY-SA 3.0 · Source

A 62-year-old woman presents for her routine mammogram. She has no personal or family history of breast cancer. She denies any breast pain, nipple discharge, or palpable lumps. Clinical breast exam is unremarkable. Her previous mammograms have been negative. The current mammogram reveals findings as shown in the image. What is the MOST appropriate next step in management?

A. Ultrasound-guided core biopsy
B. MRI of the breast
C. Stereotactic core biopsy
D. Excisional biopsy
E. Reassurance and routine screening mammography in 1 year
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CT, ultrasonography, SPECT and scintigraphy of intra-thyroid parathyroid adenoma
Image by Mnahi Bin Saeedan, Ibtisam Musallam Aljohani, Ayman Omar Khushaim, Salwa Qasim Bukhari, Salahudin Tayeb Elnaas CC BY 4.0 · Source

A 58-year-old woman presents with persistent fatigue, muscle weakness, and vague abdominal pain. Her serum calcium is 3.2 mmol/L (2.1-2.6 mmol/L), and PTH is 190 pg/mL (10-65 pg/mL). Renal function is normal. She denies any family history of endocrine disorders. Imaging studies are performed, as shown. Based on the clinical context and the imaging findings presented, which of the following represents the definitive management strategy for this patient?

A. Repeat serum calcium and PTH in three months.
B. Surgical excision of the identified lesion.
C. Order a skeletal survey to assess for osteitis fibrosa cystica.
D. Initiate treatment with cinacalcet and monitor calcium levels.
E. Perform a fine needle aspiration biopsy of the lesion.
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Contrast-enhanced ultrasound of encephaloid hepatocellular carcinoma
Image by R. Badea, Simona Ioanitescu CC BY 3.0 · Source

A 70-year-old male with known cirrhosis secondary to non-alcoholic fatty liver disease presents for routine surveillance. He has Child-Pugh class A cirrhosis and ECOG performance status 0. His recent surveillance ultrasound showed a new 3 cm lesion in segment VIII. Serum alpha-fetoprotein is elevated at 450 ng/mL. A contrast-enhanced ultrasound was performed, and representative images are shown. Considering the patient's history, clinical status, laboratory results, and the findings demonstrated in the contrast-enhanced ultrasound images, what is the MOST appropriate immediate next step in the management of this patient?

A. Referral to a multidisciplinary liver tumour board for treatment planning
B. Start systemic chemotherapy with Sorafenib
C. Repeat the contrast-enhanced ultrasound in 3 months
D. Initiate palliative care referral
E. Perform an urgent liver biopsy of the lesion
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CT, ultrasonography, SPECT and scintigraphy of intra-thyroid parathyroid adenoma
Image by Mnahi Bin Saeedan, Ibtisam Musallam Aljohani, Ayman Omar Khushaim, Salwa Qasim Bukhari, Salahudin Tayeb Elnaas CC BY 4.0 · Source

A 62-year-old woman with osteoporosis and a history of kidney stones presents for evaluation. Her calcium is 2.9 mmol/L (2.1-2.6 mmol/L), and PTH is 110 pg/mL (10-65 pg/mL). Imaging is shown. What is the MOST appropriate next step?

A. Bisphosphonate therapy
B. Cinacalcet administration
C. Vitamin D and calcium supplementation
D. Serial calcium and PTH monitoring
E. Referral for parathyroidectomy
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Ileitis terminalis bei langjaehrigem Morbus Crohn 63W - CT und MRT - 001
Image by Hellerhoff CC BY-SA 4.0 · Source

A 28-year-old with Crohn's presents with new fever and abdominal pain. The patient's CRP is elevated. Review the imaging. What is the MOST appropriate next step?

A. Surgical consultation
B. Initiate a course of corticosteroids
C. Increase current infliximab dose
D. Repeat imaging in 6 weeks
E. Start oral metronidazole and ciprofloxacin
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Post-embolization arteriogram showing coiled aneurysm (indicated by yellow arrows) of the posteriorcerebral artery with a residual aneurysmal sac.
Image by Promod Pillai, Aftab Karim, Anil Nanda CC BY 2.0 · Source

A 68-year-old woman with a history of hypertension and hyperlipidemia presents to the emergency department with a sudden onset of left-sided hemianopia and mild right-sided weakness. Her symptoms began approximately 4 hours prior to arrival. Initial neurological examination reveals intact language function and no cognitive deficits. A CT angiogram was performed, followed by endovascular coiling. The provided image shows a post-operative angiogram. Despite the intervention, the patient's hemianopia persists, and her weakness has slightly worsened. What is the MOST appropriate next step in the management of this patient?

A. Prescribe a course of high-dose corticosteroids to reduce peri-aneurysmal edema
B. Order an MRI of the brain to evaluate for ischemic changes
C. Initiate dual antiplatelet therapy with aspirin and clopidogrel
D. Repeat angiography to assess for recanalization or further aneurysm growth
E. Administer intravenous thrombolysis with alteplase
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the ED with left flank pain radiating to his groin. He reports nausea but no vomiting. Vitals are stable. A focused ultrasound is performed, as shown. What is the MOST appropriate next step in management?

A. Non-contrast CT of the abdomen and pelvis
B. Perform intravenous pyelogram
C. Insert a Foley catheter
D. Administer intravenous antibiotics
E. Discharge with analgesics and follow-up with urology
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Ovarian Cyst
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 32-year-old woman presents to her general practitioner with a 6-month history of worsening dysmenorrhea and pelvic pain, particularly on the left side. She reports no fever, weight loss, or abnormal vaginal bleeding. Her last menstrual period was 2 weeks ago and was normal. Physical examination reveals mild left adnexal tenderness. A CT scan of the pelvis was performed, the relevant image is shown. Given the clinical context and the imaging findings, what is the MOST appropriate next step in management?

A. Refer for diagnostic laparoscopy
B. Prescribe NSAIDs and schedule a follow-up appointment in 3 months
C. Initiate combined oral contraceptive pill
D. Repeat pelvic ultrasound in 6-12 weeks
E. Order serum CA-125 levels
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A 72-year-old woman presents with sudden onset shortness of breath and pleuritic chest pain. She had knee surgery 10 days ago. She has a history of hypertension. On examination, she is anxious, respiratory rate is 24, heart rate 105, BP 130/80, SpO2 92% on room air. Lungs are clear. ECG shows sinus tachycardia. There is mild swelling in the operated leg. Considering the likely diagnosis, which initial investigation is most appropriate?

A. D-dimer
B. Chest X-ray
C. CT pulmonary angiography
D. Ventilation-perfusion scan
E. Lower limb ultrasound
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Hepatic metastases from a gastric mixed adenoneuroendocrine carcinoma (MANEC).
Image by Hellerhoff CC BY-SA 3.0 · Source

A 65-year-old male with recently diagnosed gastric mixed adenoneuroendocrine carcinoma presents with unintentional weight loss. Endoscopy confirmed the diagnosis. Staging imaging is provided. His ECOG performance status is 1. Considering the extent of disease demonstrated, which of the following represents the most appropriate initial therapeutic approach?

A. Gastrectomy with D2 lymphadenectomy
B. Observation with regular imaging surveillance
C. Palliative radiotherapy to the gastric primary
D. Liver resection of dominant lesions
E. Systemic chemotherapy or targeted therapy
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Ovarian Cyst
Image by James Heilman, MD CC BY-SA 3.0 · Source

A 35-year-old female presents with chronic pelvic pain. The provided CT was performed. What is the MOST appropriate initial management?

A. Laparoscopic cystectomy
B. CA-125 level
C. Trial of oral contraceptives
D. Observation with repeat imaging in 6 weeks
E. Immediate laparotomy
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 60-year-old man, post-chemotherapy, presents with fever and abdominal pain. The images are shown. What is the MOST appropriate initial therapy?

A. Surgical resection
B. Amphotericin B
C. Albendazole
D. Broad-spectrum antibiotics
E. Percutaneous drainage
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Ultrasonographic picture taken from a patient with left ureteral stone with hydronephrosis, created in Taiwan
Image by morning2k CC BY 2.5 · Source

A 45-year-old male presents to the ED with left flank pain radiating to his groin. He reports nausea but no vomiting. Vitals are stable. A focused assessment with sonography for trauma (FAST) exam is performed, with a view obtained as shown. What is the MOST appropriate next step in management?

A. Perform a cystoscopy
B. Discharge with analgesics and follow-up with urology
C. Non-contrast CT of the abdomen and pelvis
D. Order serum lipase and amylase
E. Administer intravenous antibiotics
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PET-CT of a tuberculoma
Image by Annemie Snoeckx, Pieter Reyntiens, Damien Desbuquoit, Maarten J. Spinhoven, Paul E. Van Schil, Jan P. van Meerbeeck, Paul M. Parizel CC BY 4.0 · Source

A 32-year-old male, originally from a high-TB prevalence country, presents to the emergency department with a persistent cough for the past 3 weeks, night sweats, and a 5 kg weight loss. He denies any fever or shortness of breath. Physical examination reveals normal breath sounds bilaterally, with no wheezes or crackles. His vital signs are stable: temperature 37.2°C, heart rate 88 bpm, blood pressure 120/80 mmHg, and oxygen saturation 98% on room air. A chest X-ray was initially interpreted as showing a possible lung mass, prompting further investigation with a PET-CT scan, the axial view of which is shown. Sputum samples have been sent for microscopy and culture, but results are pending. Given the clinical presentation and the imaging findings, what is the MOST appropriate next step in management?

A. Order a bronchoscopy with bronchoalveolar lavage and transbronchial biopsy
B. Schedule a follow-up PET-CT scan in 3 months to monitor for changes in size and metabolic activity
C. Prescribe a course of broad-spectrum antibiotics to cover community-acquired pneumonia
D. Perform a CT-guided needle biopsy of the lesion for definitive diagnosis
E. Initiate a multi-drug anti-tuberculosis therapy regimen
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CT, ultrasonography, SPECT and scintigraphy of intra-thyroid parathyroid adenoma
Image by Mnahi Bin Saeedan, Ibtisam Musallam Aljohani, Ayman Omar Khushaim, Salwa Qasim Bukhari, Salahudin Tayeb Elnaas CC BY 4.0 · Source

A 62-year-old woman presents with fatigue and bone pain. Serum calcium is elevated. The provided imaging was obtained. What is the MOST likely underlying cause of her hypercalcemia?

A. Vitamin D toxicity
B. Parathyroid adenoma
C. Multiple myeloma
D. Metastatic bone disease
E. Sarcoidosis
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A 75-year-old man with type 2 diabetes and chronic kidney disease presents with a 3-day history of productive cough, fever, and pleuritic chest pain. On examination, temperature is 38.2°C, HR 105, BP 130/80, RR 22, SpO2 93% on air. Crackles are heard over the right lower lung field. Which initial investigation is most crucial for guiding management?

A. Arterial blood gas
B. Blood cultures
C. Full blood count and C-reactive protein
D. Sputum culture and sensitivity
E. Chest X-ray
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Mammogram microcalcifications in carcinoma in situ, CC, details
Image by Jmarchn CC BY-SA 3.0 · Source

A 62-year-old woman presents for routine mammography. The image is shown. What is the MOST appropriate next step?

A. Reassurance and routine screening
B. Stereotactic core biopsy
C. Ultrasound of the breast
D. MRI of the breast
E. Excisional biopsy
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Figure 3 of paper: Alveolar echinococcosis in a patient with immunosuppression.

(a) Abdominal gray-scale US shows an abscess-like hepatic image.
(b) Axial unenhanced CT shows a typical aspect of pyogenic liver abscess.
Image by Wenya Liu, Éric Delabrousse, Oleg Blagosklonov, Jing Wang, Hongchun Zeng, Yi Jiang, Jian Wang, Yongde Qin, Dominique Angèle Vuitton, Hao Wen CC BY 4.0 · Source

A 62-year-old male with a history of poorly controlled diabetes presents with fever, RUQ pain, and recent travel to a rural area. Lab results show elevated ALP and GGT. Imaging is performed. What is the MOST appropriate next step in management?

A. Metronidazole
B. Observation and serial imaging
C. Percutaneous drainage and antibiotics
D. Albendazole and surgical resection
E. Ceftriaxone and doxycycline
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CT scan of hepatocellular carcinoma, without and with IV contrast
Image by Zhenyu Pan, Guozi Yang, Tingting Yuan, Lihua Dong, Lihua Dong CC BY 4.0 · Source

A 62-year-old male with chronic hepatitis C presents with right upper quadrant pain, weight loss, and mild ascites. Laboratory tests show elevated alpha-fetoprotein. Imaging is performed. Based on the clinical context and the findings depicted in the provided imaging, which of the following factors is MOST important in assessing this patient's suitability for potentially curative surgical management?

A. Evidence of portal venous thrombosis or invasion.
B. Absolute level of serum alpha-fetoprotein.
C. Patient's body mass index.
D. Maximum diameter of the hepatic lesion.
E. Specific viral load of hepatitis C RNA.
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A middle-aged man with a 20% estimated cardiovascular risk is already on lifestyle modifications and statin therapy. Which of the following investigations can help further assess or reclassify his cardiovascular risk?

A. Coronary artery angiogram
B. Echocardiogram
C. Stress echocardiogram
D. Coronary artery calcium score
E. Exercise ECG
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