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neonatology

Practice targeted AMC-style multiple-choice questions on neonatology.

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For preterm neonate with RDS, when is surfactant most effective?

A. Prophylactically
B. After sepsis ruled out
C. After 24 hours
D. Early, within hours
E. Only if FiO2 > 0.8
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A neonate, born at 38 weeks gestation, presents with bilious vomiting starting 12 hours after birth. Antenatal ultrasound revealed polyhydramnios. On examination, the baby is active and has a distended upper abdomen but a scaphoid lower abdomen. An abdominal X-ray shows a 'double bubble' sign. Which of the following is the most appropriate next step in the management of this neonate, considering potential associated complications?

A. Immediately perform a contrast enema to rule out meconium ileus as a cause of the obstruction.
B. Initiate intravenous fluids, nasogastric decompression, and prepare for surgical intervention after stabilization.
C. Begin feeds with a hydrolysed formula to assess tolerance and rule out milk protein allergy.
D. Start the neonate on broad-spectrum antibiotics to cover potential bacterial translocation.
E. Perform an upper gastrointestinal endoscopy to visualize the obstruction and obtain biopsies.
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